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Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

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bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

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(a) Ligand-induced variationof the chemical shifts (11B (160 MHz) and 1HNMR (500 MHz)) of the helix in CD3OD at 298 K. (b) Schematicrepresentation of fast exchangebetween two degenerate helical conformers with a single NMR signaland (c) induced bias of helicity upon ligand binding (yellow), andthe anisochronous NMR signal generated. Adapted with permission fromref (1298). Copyright2013 Nature Publishing Group.
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fig44: (a) Ligand-induced variationof the chemical shifts (11B (160 MHz) and 1HNMR (500 MHz)) of the helix in CD3OD at 298 K. (b) Schematicrepresentation of fast exchangebetween two degenerate helical conformers with a single NMR signaland (c) induced bias of helicity upon ligand binding (yellow), andthe anisochronous NMR signal generated. Adapted with permission fromref (1298). Copyright2013 Nature Publishing Group.

Mentions: Techniques other than optical responses have been used tomeasureconformational change. Flood et al. used a change in conductance todirectly measure a folding process because unfolding released a boundchloride anion and changed the conductance (Figure 22 in section 3.1).595 A changein CD response can be a useful indicator of molecular motion and helicityinversion.1298−1308 Many shape changes can be easily analyzed by NMR spectroscopy. Recently,Clayden et al. showed, by 11B, 1H, and 13C NMR, that the equal distribution of left-handed (M) and right-handed (P) conformers of ahelical foldamer could be perturbed by the addition of a chiral ligand(Figure 44).1298 Upon ligand complexation to the boronic ester,chiral information was transferred along the helix, and the isochronousNMR signals of the diastereotopic nuclei were transformed into anisochronoussignals, indicating a bias in the distribution of helical conformers.When the meso diastereoisomer of the diol was usedto complex the boronic ester, no splitting of the 1H NMRsignals was observed due to the symmetry of the ligand.


Artificial Molecular Machines.

Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL - Chem. Rev. (2015)

(a) Ligand-induced variationof the chemical shifts (11B (160 MHz) and 1HNMR (500 MHz)) of the helix in CD3OD at 298 K. (b) Schematicrepresentation of fast exchangebetween two degenerate helical conformers with a single NMR signaland (c) induced bias of helicity upon ligand binding (yellow), andthe anisochronous NMR signal generated. Adapted with permission fromref (1298). Copyright2013 Nature Publishing Group.
© Copyright Policy
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4585175&req=5

fig44: (a) Ligand-induced variationof the chemical shifts (11B (160 MHz) and 1HNMR (500 MHz)) of the helix in CD3OD at 298 K. (b) Schematicrepresentation of fast exchangebetween two degenerate helical conformers with a single NMR signaland (c) induced bias of helicity upon ligand binding (yellow), andthe anisochronous NMR signal generated. Adapted with permission fromref (1298). Copyright2013 Nature Publishing Group.
Mentions: Techniques other than optical responses have been used tomeasureconformational change. Flood et al. used a change in conductance todirectly measure a folding process because unfolding released a boundchloride anion and changed the conductance (Figure 22 in section 3.1).595 A changein CD response can be a useful indicator of molecular motion and helicityinversion.1298−1308 Many shape changes can be easily analyzed by NMR spectroscopy. Recently,Clayden et al. showed, by 11B, 1H, and 13C NMR, that the equal distribution of left-handed (M) and right-handed (P) conformers of ahelical foldamer could be perturbed by the addition of a chiral ligand(Figure 44).1298 Upon ligand complexation to the boronic ester,chiral information was transferred along the helix, and the isochronousNMR signals of the diastereotopic nuclei were transformed into anisochronoussignals, indicating a bias in the distribution of helical conformers.When the meso diastereoisomer of the diol was usedto complex the boronic ester, no splitting of the 1H NMRsignals was observed due to the symmetry of the ligand.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

bonded molecules and on catenanes and rotaxanes in which switching of other protic solvents... This effect (listed in descending binding ability) stations on the thread, macrocycle In these systems, fast-responding reporters are preferred... practical applications by utilizing molecular scale changes to create macroscopic effects... The thread of these rotaxanes included an anthracene fluorophore similar application in synthetic polymers often furnishes a useful result... of Brownian motion can be exploited to great effect in the synthesis every aspect of functional molecule and materials design... An improved robotics” in which ratcheted motions of molecular components

No MeSH data available.


Related in: MedlinePlus