Limits...
Bi-frontal transcranial alternating current stimulation in the ripple range reduced overnight forgetting.

Ambrus GG, Pisoni A, Primaßin A, Turi Z, Paulus W, Antal A - Front Cell Neurosci (2015)

Bottom Line: High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans.An associative word-pair learning test was used.Cued recall performance was investigated 10 min after training and the morning following the training session.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Clinical Neurophysiology, University Medical Center, Georg-August-University of Göttingen Göttingen, Germany ; University Medical Center, Institute of Medical Psychology and Medical Sociology, Georg-August-University of Göttingen Göttingen, Germany ; Institute of Psychology, Friedrich-Schiller-University of Jena Jena, Germany.

ABSTRACT
High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans. The aim of this study was to test if transcranial Alternating Current Stimulation (tACS) of the dorsolateral prefrontal cortex (DLPFC) in the hippocampal ripple range, applied bi-frontally during encoding, could modulate declarative memory performance, measured immediately after encoding, and after a night's sleep. An associative word-pair learning test was used. During an evening encoding phase, participants received 1 mA 140 Hz tACS or sham stimulation over both DLPFCs for 10 min while being presented twice with a list of word-pairs. Cued recall performance was investigated 10 min after training and the morning following the training session. Forgetting from evening to morning was observed in the sham condition, but not in the 140 Hz stimulation condition. 140 Hz tACS during encoding may have an effect on the consolidation of declarative material.

No MeSH data available.


Related in: MedlinePlus

Difference in performance between the evening and morning sessions, when data from subjects performing under 60% in the training session of either sham or active stimulation session are retrospectively removed. Data from Marshall et al. (2006) shown for comparison. Error bars denote SEM.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4585169&req=5

Figure 3: Difference in performance between the evening and morning sessions, when data from subjects performing under 60% in the training session of either sham or active stimulation session are retrospectively removed. Data from Marshall et al. (2006) shown for comparison. Error bars denote SEM.

Mentions: Comparing the difference in accuracy in this high-performing sample, between the evening and morning sessions in the two stimulation conditions (sham: −0.71±1.73 words; active: 0.85 ± 2.07 words) using a paired t-test, we have found an enhancement of performance in the 140 Hz active condition that significantly differed from the reduction observed in the sham stimulation condition [t(13) = 3.465, p = 0.004]. A comparison of our results with that of Marshall et al. (2006) is shown in Figure 3.


Bi-frontal transcranial alternating current stimulation in the ripple range reduced overnight forgetting.

Ambrus GG, Pisoni A, Primaßin A, Turi Z, Paulus W, Antal A - Front Cell Neurosci (2015)

Difference in performance between the evening and morning sessions, when data from subjects performing under 60% in the training session of either sham or active stimulation session are retrospectively removed. Data from Marshall et al. (2006) shown for comparison. Error bars denote SEM.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585169&req=5

Figure 3: Difference in performance between the evening and morning sessions, when data from subjects performing under 60% in the training session of either sham or active stimulation session are retrospectively removed. Data from Marshall et al. (2006) shown for comparison. Error bars denote SEM.
Mentions: Comparing the difference in accuracy in this high-performing sample, between the evening and morning sessions in the two stimulation conditions (sham: −0.71±1.73 words; active: 0.85 ± 2.07 words) using a paired t-test, we have found an enhancement of performance in the 140 Hz active condition that significantly differed from the reduction observed in the sham stimulation condition [t(13) = 3.465, p = 0.004]. A comparison of our results with that of Marshall et al. (2006) is shown in Figure 3.

Bottom Line: High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans.An associative word-pair learning test was used.Cued recall performance was investigated 10 min after training and the morning following the training session.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Clinical Neurophysiology, University Medical Center, Georg-August-University of Göttingen Göttingen, Germany ; University Medical Center, Institute of Medical Psychology and Medical Sociology, Georg-August-University of Göttingen Göttingen, Germany ; Institute of Psychology, Friedrich-Schiller-University of Jena Jena, Germany.

ABSTRACT
High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans. The aim of this study was to test if transcranial Alternating Current Stimulation (tACS) of the dorsolateral prefrontal cortex (DLPFC) in the hippocampal ripple range, applied bi-frontally during encoding, could modulate declarative memory performance, measured immediately after encoding, and after a night's sleep. An associative word-pair learning test was used. During an evening encoding phase, participants received 1 mA 140 Hz tACS or sham stimulation over both DLPFCs for 10 min while being presented twice with a list of word-pairs. Cued recall performance was investigated 10 min after training and the morning following the training session. Forgetting from evening to morning was observed in the sham condition, but not in the 140 Hz stimulation condition. 140 Hz tACS during encoding may have an effect on the consolidation of declarative material.

No MeSH data available.


Related in: MedlinePlus