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Bi-frontal transcranial alternating current stimulation in the ripple range reduced overnight forgetting.

Ambrus GG, Pisoni A, Primaßin A, Turi Z, Paulus W, Antal A - Front Cell Neurosci (2015)

Bottom Line: High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans.An associative word-pair learning test was used.Cued recall performance was investigated 10 min after training and the morning following the training session.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Clinical Neurophysiology, University Medical Center, Georg-August-University of Göttingen Göttingen, Germany ; University Medical Center, Institute of Medical Psychology and Medical Sociology, Georg-August-University of Göttingen Göttingen, Germany ; Institute of Psychology, Friedrich-Schiller-University of Jena Jena, Germany.

ABSTRACT
High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans. The aim of this study was to test if transcranial Alternating Current Stimulation (tACS) of the dorsolateral prefrontal cortex (DLPFC) in the hippocampal ripple range, applied bi-frontally during encoding, could modulate declarative memory performance, measured immediately after encoding, and after a night's sleep. An associative word-pair learning test was used. During an evening encoding phase, participants received 1 mA 140 Hz tACS or sham stimulation over both DLPFCs for 10 min while being presented twice with a list of word-pairs. Cued recall performance was investigated 10 min after training and the morning following the training session. Forgetting from evening to morning was observed in the sham condition, but not in the 140 Hz stimulation condition. 140 Hz tACS during encoding may have an effect on the consolidation of declarative material.

No MeSH data available.


Related in: MedlinePlus

The experimental procedure. At 10 p.m., during 10 min of active or sham tACS stimulation the participants saw a word list two times. After an unfilled break of 10 min the subjects were tested on cued recall of the second word. Next morning at 8 a.m. they were tested again on the cued recall of the second word. The subjects participated in the study according to a repeated measures design.
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Figure 1: The experimental procedure. At 10 p.m., during 10 min of active or sham tACS stimulation the participants saw a word list two times. After an unfilled break of 10 min the subjects were tested on cued recall of the second word. Next morning at 8 a.m. they were tested again on the cued recall of the second word. The subjects participated in the study according to a repeated measures design.

Mentions: Each of the experimental sessions consisted of a training and a retest part. The training part took place at 10 p.m. and consisted of a 10 min long learning and a 5 min long test phase. During the learning phase, one of the two lists of word-pairs was presented two times, during which active 140 Hz or sham tACS was applied. The cued-recall test phase followed the learning phase after an unfilled rest period of 10 min. In the test phase, the participant saw the first member of every word-pair (1 every 5 s, with 100 ms ISI) that was presented in the training phase, and had to recall the second, corresponding word. The participants were then asked to return home and sleep, and then come back the following morning at 08 a.m. for the retest session, in which the same word list had been presented for cued recall. Until the end of the second session they were asked to avoid drinking alcohol or caffeine. The order of word-pairs and cue-words had been randomized for every presentation. There was a minimum of 1-week break between the two stimulation sessions (mean ± SD: 12 days ± 7.92). (See Figure 1 for an overview of the experimental procedure).


Bi-frontal transcranial alternating current stimulation in the ripple range reduced overnight forgetting.

Ambrus GG, Pisoni A, Primaßin A, Turi Z, Paulus W, Antal A - Front Cell Neurosci (2015)

The experimental procedure. At 10 p.m., during 10 min of active or sham tACS stimulation the participants saw a word list two times. After an unfilled break of 10 min the subjects were tested on cued recall of the second word. Next morning at 8 a.m. they were tested again on the cued recall of the second word. The subjects participated in the study according to a repeated measures design.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585169&req=5

Figure 1: The experimental procedure. At 10 p.m., during 10 min of active or sham tACS stimulation the participants saw a word list two times. After an unfilled break of 10 min the subjects were tested on cued recall of the second word. Next morning at 8 a.m. they were tested again on the cued recall of the second word. The subjects participated in the study according to a repeated measures design.
Mentions: Each of the experimental sessions consisted of a training and a retest part. The training part took place at 10 p.m. and consisted of a 10 min long learning and a 5 min long test phase. During the learning phase, one of the two lists of word-pairs was presented two times, during which active 140 Hz or sham tACS was applied. The cued-recall test phase followed the learning phase after an unfilled rest period of 10 min. In the test phase, the participant saw the first member of every word-pair (1 every 5 s, with 100 ms ISI) that was presented in the training phase, and had to recall the second, corresponding word. The participants were then asked to return home and sleep, and then come back the following morning at 08 a.m. for the retest session, in which the same word list had been presented for cued recall. Until the end of the second session they were asked to avoid drinking alcohol or caffeine. The order of word-pairs and cue-words had been randomized for every presentation. There was a minimum of 1-week break between the two stimulation sessions (mean ± SD: 12 days ± 7.92). (See Figure 1 for an overview of the experimental procedure).

Bottom Line: High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans.An associative word-pair learning test was used.Cued recall performance was investigated 10 min after training and the morning following the training session.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Clinical Neurophysiology, University Medical Center, Georg-August-University of Göttingen Göttingen, Germany ; University Medical Center, Institute of Medical Psychology and Medical Sociology, Georg-August-University of Göttingen Göttingen, Germany ; Institute of Psychology, Friedrich-Schiller-University of Jena Jena, Germany.

ABSTRACT
High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans. The aim of this study was to test if transcranial Alternating Current Stimulation (tACS) of the dorsolateral prefrontal cortex (DLPFC) in the hippocampal ripple range, applied bi-frontally during encoding, could modulate declarative memory performance, measured immediately after encoding, and after a night's sleep. An associative word-pair learning test was used. During an evening encoding phase, participants received 1 mA 140 Hz tACS or sham stimulation over both DLPFCs for 10 min while being presented twice with a list of word-pairs. Cued recall performance was investigated 10 min after training and the morning following the training session. Forgetting from evening to morning was observed in the sham condition, but not in the 140 Hz stimulation condition. 140 Hz tACS during encoding may have an effect on the consolidation of declarative material.

No MeSH data available.


Related in: MedlinePlus