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Recovery of resting brain connectivity ensuing mild traumatic brain injury.

Bharath RD, Munivenkatappa A, Gohel S, Panda R, Saini J, Rajeswaran J, Shukla D, Bhagavatula ID, Biswal BB - Front Hum Neurosci (2015)

Bottom Line: We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time.Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections.Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

View Article: PubMed Central - PubMed

Affiliation: Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.

ABSTRACT
Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

No MeSH data available.


Related in: MedlinePlus

Correlation between various behavior scores and the RSFC strength for the ROI pairs showing differences between CTRL and mild TBI as well as within mild TBI group. Correlation matrices show the correlation between each possible pairs. Significant linear correlations are highlighted by a circle (p < 0.01).
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Figure 5: Correlation between various behavior scores and the RSFC strength for the ROI pairs showing differences between CTRL and mild TBI as well as within mild TBI group. Correlation matrices show the correlation between each possible pairs. Significant linear correlations are highlighted by a circle (p < 0.01).

Mentions: All subjects at the initial evaluation within 12 days of injury had below normal scores for the various neuropsychological tests on attention, executive functions, learning, and memory. Sustained attention and sensory registration scores improved in first 3 months. Response speed, response inhibition, visuospatial memory, and visuospatial construction scores showed progressive recovery with maximum recovery in 1–3 month period and near normal recovery by 6 months post injury. Encoding and retrieval of learning and memory and category fluency improved overtime with a steep increase during the 3–6 months period. Linear correlation of behavioral scores with RSFC strength revealed five networks significantly correlated with the memory scores (Figure 5). The Lingual-DMN network connections correlated positively with the Auditory verbal learning test (AVLT) 1 scores and Posterior DMN-inferior frontal connectivity correlated negatively with complex figure tracing test. The connections of the salience network with DMN and precentral network correlated negatively with the Verbal n Back (VnB) errors. Salience-Pre central network connectivity positively correlated with VnB hits. Positive correlations of salience-DMN network were seen with AVLT4. Insula-precentral network were correlated positively with VnB errors and negatively with AVLT long-term potential retention.


Recovery of resting brain connectivity ensuing mild traumatic brain injury.

Bharath RD, Munivenkatappa A, Gohel S, Panda R, Saini J, Rajeswaran J, Shukla D, Bhagavatula ID, Biswal BB - Front Hum Neurosci (2015)

Correlation between various behavior scores and the RSFC strength for the ROI pairs showing differences between CTRL and mild TBI as well as within mild TBI group. Correlation matrices show the correlation between each possible pairs. Significant linear correlations are highlighted by a circle (p < 0.01).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585122&req=5

Figure 5: Correlation between various behavior scores and the RSFC strength for the ROI pairs showing differences between CTRL and mild TBI as well as within mild TBI group. Correlation matrices show the correlation between each possible pairs. Significant linear correlations are highlighted by a circle (p < 0.01).
Mentions: All subjects at the initial evaluation within 12 days of injury had below normal scores for the various neuropsychological tests on attention, executive functions, learning, and memory. Sustained attention and sensory registration scores improved in first 3 months. Response speed, response inhibition, visuospatial memory, and visuospatial construction scores showed progressive recovery with maximum recovery in 1–3 month period and near normal recovery by 6 months post injury. Encoding and retrieval of learning and memory and category fluency improved overtime with a steep increase during the 3–6 months period. Linear correlation of behavioral scores with RSFC strength revealed five networks significantly correlated with the memory scores (Figure 5). The Lingual-DMN network connections correlated positively with the Auditory verbal learning test (AVLT) 1 scores and Posterior DMN-inferior frontal connectivity correlated negatively with complex figure tracing test. The connections of the salience network with DMN and precentral network correlated negatively with the Verbal n Back (VnB) errors. Salience-Pre central network connectivity positively correlated with VnB hits. Positive correlations of salience-DMN network were seen with AVLT4. Insula-precentral network were correlated positively with VnB errors and negatively with AVLT long-term potential retention.

Bottom Line: We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time.Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections.Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

View Article: PubMed Central - PubMed

Affiliation: Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.

ABSTRACT
Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

No MeSH data available.


Related in: MedlinePlus