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Recovery of resting brain connectivity ensuing mild traumatic brain injury.

Bharath RD, Munivenkatappa A, Gohel S, Panda R, Saini J, Rajeswaran J, Shukla D, Bhagavatula ID, Biswal BB - Front Hum Neurosci (2015)

Bottom Line: We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time.Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections.Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

View Article: PubMed Central - PubMed

Affiliation: Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.

ABSTRACT
Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

No MeSH data available.


Related in: MedlinePlus

Group level differences observed in the RSFC between healthy controls and TBI subjects during recovery. (A) Mean correlation matrices for each of the groups, (B) ROI pairs showing differences in the connectivity between HC and mild TBI (p < 0.005), (C) mean connectivity strength for each of the ROI pair showing differences between the HC and mTBI subjects.
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Figure 4: Group level differences observed in the RSFC between healthy controls and TBI subjects during recovery. (A) Mean correlation matrices for each of the groups, (B) ROI pairs showing differences in the connectivity between HC and mild TBI (p < 0.005), (C) mean connectivity strength for each of the ROI pair showing differences between the HC and mTBI subjects.

Mentions: Group level comparisons with healthy controls (Figure 4) revealed 15 ROI pairs, which had significant connectivity differences during the recovery period. No overlap was observed between within mTBI group differences and the group comparison between controls and mTBI subjects. Large-scale differences in RSFC strength were observed in the contrast between HC vs. R1 and HC vs. R2 i.e., patients were different from healthy control at R1 and R2. The functional connectivity differences at R3, however, were minimal. This finding is in agreement with the results of the mTBI group analysis mentioned above. Significant changes in connectivity were seen within the bilateral parietal lobes (right post central gyrus, right angular gyrus, right supramarginal gyrus, left superior parietal lobule, left precuneus) and bilateral frontal lobes (right superior middle and bilateral inferior frontal gyrus, left medial frontal gyrus). Involvement of other areas like the right middle temporal gyrus, left superior temporal gyrus, bilateral culmen, and left middle occipital gyrus were also observed.


Recovery of resting brain connectivity ensuing mild traumatic brain injury.

Bharath RD, Munivenkatappa A, Gohel S, Panda R, Saini J, Rajeswaran J, Shukla D, Bhagavatula ID, Biswal BB - Front Hum Neurosci (2015)

Group level differences observed in the RSFC between healthy controls and TBI subjects during recovery. (A) Mean correlation matrices for each of the groups, (B) ROI pairs showing differences in the connectivity between HC and mild TBI (p < 0.005), (C) mean connectivity strength for each of the ROI pair showing differences between the HC and mTBI subjects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585122&req=5

Figure 4: Group level differences observed in the RSFC between healthy controls and TBI subjects during recovery. (A) Mean correlation matrices for each of the groups, (B) ROI pairs showing differences in the connectivity between HC and mild TBI (p < 0.005), (C) mean connectivity strength for each of the ROI pair showing differences between the HC and mTBI subjects.
Mentions: Group level comparisons with healthy controls (Figure 4) revealed 15 ROI pairs, which had significant connectivity differences during the recovery period. No overlap was observed between within mTBI group differences and the group comparison between controls and mTBI subjects. Large-scale differences in RSFC strength were observed in the contrast between HC vs. R1 and HC vs. R2 i.e., patients were different from healthy control at R1 and R2. The functional connectivity differences at R3, however, were minimal. This finding is in agreement with the results of the mTBI group analysis mentioned above. Significant changes in connectivity were seen within the bilateral parietal lobes (right post central gyrus, right angular gyrus, right supramarginal gyrus, left superior parietal lobule, left precuneus) and bilateral frontal lobes (right superior middle and bilateral inferior frontal gyrus, left medial frontal gyrus). Involvement of other areas like the right middle temporal gyrus, left superior temporal gyrus, bilateral culmen, and left middle occipital gyrus were also observed.

Bottom Line: We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time.Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections.Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

View Article: PubMed Central - PubMed

Affiliation: Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.

ABSTRACT
Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

No MeSH data available.


Related in: MedlinePlus