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Recovery of resting brain connectivity ensuing mild traumatic brain injury.

Bharath RD, Munivenkatappa A, Gohel S, Panda R, Saini J, Rajeswaran J, Shukla D, Bhagavatula ID, Biswal BB - Front Hum Neurosci (2015)

Bottom Line: We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time.Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections.Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

View Article: PubMed Central - PubMed

Affiliation: Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.

ABSTRACT
Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

No MeSH data available.


Related in: MedlinePlus

Group level independent component maps. (A) Lingual gyrus, (B) left frontal parietal network, (C) Salience network, (D) default mode network, (E) motor network, (F) posterior default mode network, (G) higher visual cortex, (H) Dorsal attention network, (I) Inferior frontal gyrus, (J) Fronta-parietal network, (K) Insular network, (L) cerebellum network, (M) pre-central gyrus, (N) basal ganglia, (O) temporal gyrus network.
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Figure 1: Group level independent component maps. (A) Lingual gyrus, (B) left frontal parietal network, (C) Salience network, (D) default mode network, (E) motor network, (F) posterior default mode network, (G) higher visual cortex, (H) Dorsal attention network, (I) Inferior frontal gyrus, (J) Fronta-parietal network, (K) Insular network, (L) cerebellum network, (M) pre-central gyrus, (N) basal ganglia, (O) temporal gyrus network.

Mentions: Group level independent component analysis revealed 15 visually identifiable resting state networks (RSN) as demonstrated in Figure 1. For each of the identified RSN, we segmented the IC maps into non-contiguous clusters and peak voxel-coordinates were derived using AFNI program 3dClustSim. A 6 mm sphere was created surrounding the peak coordinate to derive a set of 57 ROIs that are listed in the Table 2.


Recovery of resting brain connectivity ensuing mild traumatic brain injury.

Bharath RD, Munivenkatappa A, Gohel S, Panda R, Saini J, Rajeswaran J, Shukla D, Bhagavatula ID, Biswal BB - Front Hum Neurosci (2015)

Group level independent component maps. (A) Lingual gyrus, (B) left frontal parietal network, (C) Salience network, (D) default mode network, (E) motor network, (F) posterior default mode network, (G) higher visual cortex, (H) Dorsal attention network, (I) Inferior frontal gyrus, (J) Fronta-parietal network, (K) Insular network, (L) cerebellum network, (M) pre-central gyrus, (N) basal ganglia, (O) temporal gyrus network.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585122&req=5

Figure 1: Group level independent component maps. (A) Lingual gyrus, (B) left frontal parietal network, (C) Salience network, (D) default mode network, (E) motor network, (F) posterior default mode network, (G) higher visual cortex, (H) Dorsal attention network, (I) Inferior frontal gyrus, (J) Fronta-parietal network, (K) Insular network, (L) cerebellum network, (M) pre-central gyrus, (N) basal ganglia, (O) temporal gyrus network.
Mentions: Group level independent component analysis revealed 15 visually identifiable resting state networks (RSN) as demonstrated in Figure 1. For each of the identified RSN, we segmented the IC maps into non-contiguous clusters and peak voxel-coordinates were derived using AFNI program 3dClustSim. A 6 mm sphere was created surrounding the peak coordinate to derive a set of 57 ROIs that are listed in the Table 2.

Bottom Line: We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time.Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections.Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

View Article: PubMed Central - PubMed

Affiliation: Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.

ABSTRACT
Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

No MeSH data available.


Related in: MedlinePlus