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Multi-modal representation of effector modality in frontal cortex during rule switching.

Hodgson TL, Parris BA, Benattayallah A, Summers IR - Front Hum Neurosci (2015)

Bottom Line: Participants performed a rule switching task using different effector modalities.Multivariate analysis revealed that the pattern of activity evoked by Flip rule Feedbacks within an apparently supra modal frontal region (dorsolateral frontal cortex) discriminated between response epochs.The results are consistent with the existence of multi-modal representations of stimulus-response (SR) rules within the frontal cerebral cortex.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, University of Lincoln Lincoln, UK.

ABSTRACT
We report a functional magnetic resonance imaging (fMRI) study which investigated whether brain areas involved in updating task rules within the frontal lobe of the cerebral cortex show activity related to the modality of motor response used in the task. Participants performed a rule switching task using different effector modalities. In some blocks participants responded with left/right button presses, whilst in other blocks left/right saccades were required. The color of a Cue event instructed a left or right response based upon a rule, followed by a Feedback which indicated whether the rule was to stay the same or "Flip" on the next trial. The findings revealed variation in the locus of activity within the ventrolateral frontal cortex dependent upon effector modality. Other frontal areas showed no significant difference in activity between response epochs but changed their pattern of connectivity with posterior cortical areas dependent upon response. Multivariate analysis revealed that the pattern of activity evoked by Flip rule Feedbacks within an apparently supra modal frontal region (dorsolateral frontal cortex) discriminated between response epochs. The results are consistent with the existence of multi-modal representations of stimulus-response (SR) rules within the frontal cerebral cortex.

No MeSH data available.


Sub regions of the ventrolateral frontal cortex which were found to show activity which varied with response modality during processing of Flip rule feedback events.
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Figure 3: Sub regions of the ventrolateral frontal cortex which were found to show activity which varied with response modality during processing of Flip rule feedback events.

Mentions: No voxels were found whose activity depended upon the interaction effect between Response and Trial type, even when an inclusive mask corresponding to the main effect of Flip minus Hold rule Feedbacks and an appropriate SVC was applied. Using the exclusive masking approach, in which the contrast of Flip minus Hold trial feedback was exclusively masked with regions showing Eye/Hand response (i.e., Cue event) locked activity, a number of regions were found to be significantly activated suggesting that these response execution related regions were also activate during rule updating (Figure 2; Table 3A). Previous research had identified areas of the ventrolateral frontal cortex as showing response specific activity during cognitive tasks including stop signal and anti saccades/anti pointing tasks. In order to test whether a similar organization could be observed during rule switching, an ROI encompassing the bilateral ventrolateral frontal cortex (combination of BA45, BA47, BA44 as defined within the WFU Pickatlas toolbox) and associated SVC was applied to the data. This revealed that Hand response epochs were associated with a more ventral and posterior locus of activity, whereas for the reverse comparison of Eye epochs exclusively masked with Hand epochs, a more dorsal and anterior locus confined to the left hemisphere was highlighted (Table 3B; Figure 3).


Multi-modal representation of effector modality in frontal cortex during rule switching.

Hodgson TL, Parris BA, Benattayallah A, Summers IR - Front Hum Neurosci (2015)

Sub regions of the ventrolateral frontal cortex which were found to show activity which varied with response modality during processing of Flip rule feedback events.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585120&req=5

Figure 3: Sub regions of the ventrolateral frontal cortex which were found to show activity which varied with response modality during processing of Flip rule feedback events.
Mentions: No voxels were found whose activity depended upon the interaction effect between Response and Trial type, even when an inclusive mask corresponding to the main effect of Flip minus Hold rule Feedbacks and an appropriate SVC was applied. Using the exclusive masking approach, in which the contrast of Flip minus Hold trial feedback was exclusively masked with regions showing Eye/Hand response (i.e., Cue event) locked activity, a number of regions were found to be significantly activated suggesting that these response execution related regions were also activate during rule updating (Figure 2; Table 3A). Previous research had identified areas of the ventrolateral frontal cortex as showing response specific activity during cognitive tasks including stop signal and anti saccades/anti pointing tasks. In order to test whether a similar organization could be observed during rule switching, an ROI encompassing the bilateral ventrolateral frontal cortex (combination of BA45, BA47, BA44 as defined within the WFU Pickatlas toolbox) and associated SVC was applied to the data. This revealed that Hand response epochs were associated with a more ventral and posterior locus of activity, whereas for the reverse comparison of Eye epochs exclusively masked with Hand epochs, a more dorsal and anterior locus confined to the left hemisphere was highlighted (Table 3B; Figure 3).

Bottom Line: Participants performed a rule switching task using different effector modalities.Multivariate analysis revealed that the pattern of activity evoked by Flip rule Feedbacks within an apparently supra modal frontal region (dorsolateral frontal cortex) discriminated between response epochs.The results are consistent with the existence of multi-modal representations of stimulus-response (SR) rules within the frontal cerebral cortex.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, University of Lincoln Lincoln, UK.

ABSTRACT
We report a functional magnetic resonance imaging (fMRI) study which investigated whether brain areas involved in updating task rules within the frontal lobe of the cerebral cortex show activity related to the modality of motor response used in the task. Participants performed a rule switching task using different effector modalities. In some blocks participants responded with left/right button presses, whilst in other blocks left/right saccades were required. The color of a Cue event instructed a left or right response based upon a rule, followed by a Feedback which indicated whether the rule was to stay the same or "Flip" on the next trial. The findings revealed variation in the locus of activity within the ventrolateral frontal cortex dependent upon effector modality. Other frontal areas showed no significant difference in activity between response epochs but changed their pattern of connectivity with posterior cortical areas dependent upon response. Multivariate analysis revealed that the pattern of activity evoked by Flip rule Feedbacks within an apparently supra modal frontal region (dorsolateral frontal cortex) discriminated between response epochs. The results are consistent with the existence of multi-modal representations of stimulus-response (SR) rules within the frontal cerebral cortex.

No MeSH data available.