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Multi-modal representation of effector modality in frontal cortex during rule switching.

Hodgson TL, Parris BA, Benattayallah A, Summers IR - Front Hum Neurosci (2015)

Bottom Line: Participants performed a rule switching task using different effector modalities.Multivariate analysis revealed that the pattern of activity evoked by Flip rule Feedbacks within an apparently supra modal frontal region (dorsolateral frontal cortex) discriminated between response epochs.The results are consistent with the existence of multi-modal representations of stimulus-response (SR) rules within the frontal cerebral cortex.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, University of Lincoln Lincoln, UK.

ABSTRACT
We report a functional magnetic resonance imaging (fMRI) study which investigated whether brain areas involved in updating task rules within the frontal lobe of the cerebral cortex show activity related to the modality of motor response used in the task. Participants performed a rule switching task using different effector modalities. In some blocks participants responded with left/right button presses, whilst in other blocks left/right saccades were required. The color of a Cue event instructed a left or right response based upon a rule, followed by a Feedback which indicated whether the rule was to stay the same or "Flip" on the next trial. The findings revealed variation in the locus of activity within the ventrolateral frontal cortex dependent upon effector modality. Other frontal areas showed no significant difference in activity between response epochs but changed their pattern of connectivity with posterior cortical areas dependent upon response. Multivariate analysis revealed that the pattern of activity evoked by Flip rule Feedbacks within an apparently supra modal frontal region (dorsolateral frontal cortex) discriminated between response epochs. The results are consistent with the existence of multi-modal representations of stimulus-response (SR) rules within the frontal cerebral cortex.

No MeSH data available.


Rendered surface activation views of event locked activity for main effect of Cue and contrast of Flip minus Hold Feedback events which was either exclusive to Hand or Eye response periods or overlapping between the two response modes (conjunction analysis). The exclusive masking approach was used to compare Eye and Hand activations. See Table 2 for activation coordinates, anatomical labels and Brodmann Area classification. Green circle shows dorsolateral frontal cortex locus used as the basis of the Psycho-physiological interaction analysis (PPI) and MVPA (BA 9/46). Blue circle indicates region activated by Cue events corresponding to the location of human frontal eye fields (FEF; BA6). Activations are shown thresholded at p < 0.05 FWE corrected.
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Figure 2: Rendered surface activation views of event locked activity for main effect of Cue and contrast of Flip minus Hold Feedback events which was either exclusive to Hand or Eye response periods or overlapping between the two response modes (conjunction analysis). The exclusive masking approach was used to compare Eye and Hand activations. See Table 2 for activation coordinates, anatomical labels and Brodmann Area classification. Green circle shows dorsolateral frontal cortex locus used as the basis of the Psycho-physiological interaction analysis (PPI) and MVPA (BA 9/46). Blue circle indicates region activated by Cue events corresponding to the location of human frontal eye fields (FEF; BA6). Activations are shown thresholded at p < 0.05 FWE corrected.

Mentions: Direct statistical contrasts for Feedback and Cue evoked activity (independent of Trial type) revealed no differences between Eye and Hand blocks. Cue locked activity in Eye blocks masked by Hand blocks showed activity in the left frontal eye fields (FEF), medial parietal and occipital cortex along with the Middle temporal and parahippocampal gyrus (Table 2; Figure 2). The reverse comparison of Cue related activity in Hand epochs exclusively masked by Eye epochs highlighted the bilateral post-central gyrus, cerebellum and middle occipital gyrus (Table 2; Figure 2). For Feedback evoked activations exclusive masking analysis showed Hand epoch activity exclusive to the right post-central gyrus and left inferior frontal gyrus. No activity evoked by Feedback events was found to be exclusive to Eye blocks.


Multi-modal representation of effector modality in frontal cortex during rule switching.

Hodgson TL, Parris BA, Benattayallah A, Summers IR - Front Hum Neurosci (2015)

Rendered surface activation views of event locked activity for main effect of Cue and contrast of Flip minus Hold Feedback events which was either exclusive to Hand or Eye response periods or overlapping between the two response modes (conjunction analysis). The exclusive masking approach was used to compare Eye and Hand activations. See Table 2 for activation coordinates, anatomical labels and Brodmann Area classification. Green circle shows dorsolateral frontal cortex locus used as the basis of the Psycho-physiological interaction analysis (PPI) and MVPA (BA 9/46). Blue circle indicates region activated by Cue events corresponding to the location of human frontal eye fields (FEF; BA6). Activations are shown thresholded at p < 0.05 FWE corrected.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585120&req=5

Figure 2: Rendered surface activation views of event locked activity for main effect of Cue and contrast of Flip minus Hold Feedback events which was either exclusive to Hand or Eye response periods or overlapping between the two response modes (conjunction analysis). The exclusive masking approach was used to compare Eye and Hand activations. See Table 2 for activation coordinates, anatomical labels and Brodmann Area classification. Green circle shows dorsolateral frontal cortex locus used as the basis of the Psycho-physiological interaction analysis (PPI) and MVPA (BA 9/46). Blue circle indicates region activated by Cue events corresponding to the location of human frontal eye fields (FEF; BA6). Activations are shown thresholded at p < 0.05 FWE corrected.
Mentions: Direct statistical contrasts for Feedback and Cue evoked activity (independent of Trial type) revealed no differences between Eye and Hand blocks. Cue locked activity in Eye blocks masked by Hand blocks showed activity in the left frontal eye fields (FEF), medial parietal and occipital cortex along with the Middle temporal and parahippocampal gyrus (Table 2; Figure 2). The reverse comparison of Cue related activity in Hand epochs exclusively masked by Eye epochs highlighted the bilateral post-central gyrus, cerebellum and middle occipital gyrus (Table 2; Figure 2). For Feedback evoked activations exclusive masking analysis showed Hand epoch activity exclusive to the right post-central gyrus and left inferior frontal gyrus. No activity evoked by Feedback events was found to be exclusive to Eye blocks.

Bottom Line: Participants performed a rule switching task using different effector modalities.Multivariate analysis revealed that the pattern of activity evoked by Flip rule Feedbacks within an apparently supra modal frontal region (dorsolateral frontal cortex) discriminated between response epochs.The results are consistent with the existence of multi-modal representations of stimulus-response (SR) rules within the frontal cerebral cortex.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, University of Lincoln Lincoln, UK.

ABSTRACT
We report a functional magnetic resonance imaging (fMRI) study which investigated whether brain areas involved in updating task rules within the frontal lobe of the cerebral cortex show activity related to the modality of motor response used in the task. Participants performed a rule switching task using different effector modalities. In some blocks participants responded with left/right button presses, whilst in other blocks left/right saccades were required. The color of a Cue event instructed a left or right response based upon a rule, followed by a Feedback which indicated whether the rule was to stay the same or "Flip" on the next trial. The findings revealed variation in the locus of activity within the ventrolateral frontal cortex dependent upon effector modality. Other frontal areas showed no significant difference in activity between response epochs but changed their pattern of connectivity with posterior cortical areas dependent upon response. Multivariate analysis revealed that the pattern of activity evoked by Flip rule Feedbacks within an apparently supra modal frontal region (dorsolateral frontal cortex) discriminated between response epochs. The results are consistent with the existence of multi-modal representations of stimulus-response (SR) rules within the frontal cerebral cortex.

No MeSH data available.