Limits...
Task-related activity in sensorimotor cortex in Parkinson's disease and essential tremor: changes in beta and gamma bands.

Rowland NC, De Hemptinne C, Swann NC, Qasim S, Miocinovic S, Ostrem JL, Knight RT, Starr PA - Front Hum Neurosci (2015)

Bottom Line: In Parkinson's disease patients in the OFF medication state, basal ganglia local field potentials exhibit changes in beta and gamma oscillations that correlate with reduced voluntary movement, manifested as rigidity and akinesia.We analyzed ECoG potentials during a computer-controlled reaching task designed to separate movement preparation from movement execution and compared findings to similar invasive recordings in eight patients with essential tremor (3 females, ages 59-78), a condition not associated with rigidity or akinesia.We show that (1) cortical beta spectral power at rest does not differ between Parkinson's and essential tremor patients (p = 0.85), (2) early motor preparation in Parkinson's patients in the OFF medication state is associated with a larger beta desynchronization compared to patients with essential tremor (p = 0.0061), and (3) cortical broadband gamma power is elevated in Parkinson's patients compared to essential tremor patients during both rest and task recordings (p = 0.004).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Surgery, University of California, San Francisco San Francisco, CA, USA.

ABSTRACT
In Parkinson's disease patients in the OFF medication state, basal ganglia local field potentials exhibit changes in beta and gamma oscillations that correlate with reduced voluntary movement, manifested as rigidity and akinesia. However, magnetoencephalography and low-resolution electrocorticography (ECoG) studies in Parkinson's patients suggest that changes in sensorimotor cortical oscillations differ from those of the basal ganglia. To more clearly define the role of sensorimotor cortex oscillatory activity in Parkinson's, we performed intraoperative, high-resolution (4 mm spacing) ECoG recordings in 10 Parkinson's patients (2 females, ages 47-72) undergoing deep brain stimulation (DBS) lead placement in the awake, OFF medication state. We analyzed ECoG potentials during a computer-controlled reaching task designed to separate movement preparation from movement execution and compared findings to similar invasive recordings in eight patients with essential tremor (3 females, ages 59-78), a condition not associated with rigidity or akinesia. We show that (1) cortical beta spectral power at rest does not differ between Parkinson's and essential tremor patients (p = 0.85), (2) early motor preparation in Parkinson's patients in the OFF medication state is associated with a larger beta desynchronization compared to patients with essential tremor (p = 0.0061), and (3) cortical broadband gamma power is elevated in Parkinson's patients compared to essential tremor patients during both rest and task recordings (p = 0.004). Our findings suggest an oscillatory profile in sensorimotor cortex of Parkinson's patients that, in contrast to the basal ganglia, may act to promote movement to oppose the anti-kinetic bias of the dopamine-depleted state.

No MeSH data available.


Related in: MedlinePlus

Beta and gamma spectral power at REST and during different task periods. (A) Comparison of average log10 beta power between Parkinson's disease (n = 10 subjects) and essential tremor (n = 8 subjects) groups for the REST and task periods. Horizontal line within the boxplot indicates median value, lower and upper box limits indicate the interquartile range (25 and 75%, respectively) and whiskers extend to minimum and maximum values of the dataset. Filled dark circles indicate outliers. No differences were found for any period. ET, essential tremor; PD, Parkinson's disease. (B) Comparison of average log10 broadband gamma power between Parkinson's disease (n = 10 subjects) and essential tremor (n = 8 subjects) groups for the REST and task periods. Boxplots constructed as in (A). *prs < 0.05, **prs < 0.01, refer to Results section for specific p-values. ET, essential tremor; PD, Parkinson's disease. (C) Cortical topography of the broadband gamma frequency band differences between Parkinson's disease and essential tremor groups, illustrated here for the MOVE period. Boxplots constructed as in (A). Values in parentheses indicate number of patients with contact coverage of a particular cortical region. CenSul, central sulcus; ET, essential tremor; PD, Parkinson's disease; PoCeGy, postcentral gyrus; PoCeSu, postcentral sulcus; PrCeGy, precentral gyrus; PrCeSu, precentral sulcus; SuFrGy, superior frontal gyrus; SuPaLo, Superior parietal lobule; *prs < 0.05, refer to Results section for specific p-values.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4585033&req=5

Figure 2: Beta and gamma spectral power at REST and during different task periods. (A) Comparison of average log10 beta power between Parkinson's disease (n = 10 subjects) and essential tremor (n = 8 subjects) groups for the REST and task periods. Horizontal line within the boxplot indicates median value, lower and upper box limits indicate the interquartile range (25 and 75%, respectively) and whiskers extend to minimum and maximum values of the dataset. Filled dark circles indicate outliers. No differences were found for any period. ET, essential tremor; PD, Parkinson's disease. (B) Comparison of average log10 broadband gamma power between Parkinson's disease (n = 10 subjects) and essential tremor (n = 8 subjects) groups for the REST and task periods. Boxplots constructed as in (A). *prs < 0.05, **prs < 0.01, refer to Results section for specific p-values. ET, essential tremor; PD, Parkinson's disease. (C) Cortical topography of the broadband gamma frequency band differences between Parkinson's disease and essential tremor groups, illustrated here for the MOVE period. Boxplots constructed as in (A). Values in parentheses indicate number of patients with contact coverage of a particular cortical region. CenSul, central sulcus; ET, essential tremor; PD, Parkinson's disease; PoCeGy, postcentral gyrus; PoCeSu, postcentral sulcus; PrCeGy, precentral gyrus; PrCeSu, precentral sulcus; SuFrGy, superior frontal gyrus; SuPaLo, Superior parietal lobule; *prs < 0.05, refer to Results section for specific p-values.

Mentions: Log beta power averaged over all cortical areas was similar in both groups for all periods (REST—Parkinson's disease: 0.78 ± 0.17, essential tremor: 0.66 ± 0.15, prs = 0.85; HOLD—Parkinson's disease: 0.99 ± 0.16, essential tremor: 0.77 ± 0.15, prs = 0.56; PREPARATION—Parkinson's disease: 0.78 ± 0.17, essential tremor: 0.62 ± 0.14, prs = 0.85 and MOVE—Parkinson's disease: 0.18 ± 0.11, essential tremor: −0.090±0.11, prs = 0.32, mean ± se, all units = log10(μV)2/Hz) (Figure 2A).


Task-related activity in sensorimotor cortex in Parkinson's disease and essential tremor: changes in beta and gamma bands.

Rowland NC, De Hemptinne C, Swann NC, Qasim S, Miocinovic S, Ostrem JL, Knight RT, Starr PA - Front Hum Neurosci (2015)

Beta and gamma spectral power at REST and during different task periods. (A) Comparison of average log10 beta power between Parkinson's disease (n = 10 subjects) and essential tremor (n = 8 subjects) groups for the REST and task periods. Horizontal line within the boxplot indicates median value, lower and upper box limits indicate the interquartile range (25 and 75%, respectively) and whiskers extend to minimum and maximum values of the dataset. Filled dark circles indicate outliers. No differences were found for any period. ET, essential tremor; PD, Parkinson's disease. (B) Comparison of average log10 broadband gamma power between Parkinson's disease (n = 10 subjects) and essential tremor (n = 8 subjects) groups for the REST and task periods. Boxplots constructed as in (A). *prs < 0.05, **prs < 0.01, refer to Results section for specific p-values. ET, essential tremor; PD, Parkinson's disease. (C) Cortical topography of the broadband gamma frequency band differences between Parkinson's disease and essential tremor groups, illustrated here for the MOVE period. Boxplots constructed as in (A). Values in parentheses indicate number of patients with contact coverage of a particular cortical region. CenSul, central sulcus; ET, essential tremor; PD, Parkinson's disease; PoCeGy, postcentral gyrus; PoCeSu, postcentral sulcus; PrCeGy, precentral gyrus; PrCeSu, precentral sulcus; SuFrGy, superior frontal gyrus; SuPaLo, Superior parietal lobule; *prs < 0.05, refer to Results section for specific p-values.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585033&req=5

Figure 2: Beta and gamma spectral power at REST and during different task periods. (A) Comparison of average log10 beta power between Parkinson's disease (n = 10 subjects) and essential tremor (n = 8 subjects) groups for the REST and task periods. Horizontal line within the boxplot indicates median value, lower and upper box limits indicate the interquartile range (25 and 75%, respectively) and whiskers extend to minimum and maximum values of the dataset. Filled dark circles indicate outliers. No differences were found for any period. ET, essential tremor; PD, Parkinson's disease. (B) Comparison of average log10 broadband gamma power between Parkinson's disease (n = 10 subjects) and essential tremor (n = 8 subjects) groups for the REST and task periods. Boxplots constructed as in (A). *prs < 0.05, **prs < 0.01, refer to Results section for specific p-values. ET, essential tremor; PD, Parkinson's disease. (C) Cortical topography of the broadband gamma frequency band differences between Parkinson's disease and essential tremor groups, illustrated here for the MOVE period. Boxplots constructed as in (A). Values in parentheses indicate number of patients with contact coverage of a particular cortical region. CenSul, central sulcus; ET, essential tremor; PD, Parkinson's disease; PoCeGy, postcentral gyrus; PoCeSu, postcentral sulcus; PrCeGy, precentral gyrus; PrCeSu, precentral sulcus; SuFrGy, superior frontal gyrus; SuPaLo, Superior parietal lobule; *prs < 0.05, refer to Results section for specific p-values.
Mentions: Log beta power averaged over all cortical areas was similar in both groups for all periods (REST—Parkinson's disease: 0.78 ± 0.17, essential tremor: 0.66 ± 0.15, prs = 0.85; HOLD—Parkinson's disease: 0.99 ± 0.16, essential tremor: 0.77 ± 0.15, prs = 0.56; PREPARATION—Parkinson's disease: 0.78 ± 0.17, essential tremor: 0.62 ± 0.14, prs = 0.85 and MOVE—Parkinson's disease: 0.18 ± 0.11, essential tremor: −0.090±0.11, prs = 0.32, mean ± se, all units = log10(μV)2/Hz) (Figure 2A).

Bottom Line: In Parkinson's disease patients in the OFF medication state, basal ganglia local field potentials exhibit changes in beta and gamma oscillations that correlate with reduced voluntary movement, manifested as rigidity and akinesia.We analyzed ECoG potentials during a computer-controlled reaching task designed to separate movement preparation from movement execution and compared findings to similar invasive recordings in eight patients with essential tremor (3 females, ages 59-78), a condition not associated with rigidity or akinesia.We show that (1) cortical beta spectral power at rest does not differ between Parkinson's and essential tremor patients (p = 0.85), (2) early motor preparation in Parkinson's patients in the OFF medication state is associated with a larger beta desynchronization compared to patients with essential tremor (p = 0.0061), and (3) cortical broadband gamma power is elevated in Parkinson's patients compared to essential tremor patients during both rest and task recordings (p = 0.004).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Surgery, University of California, San Francisco San Francisco, CA, USA.

ABSTRACT
In Parkinson's disease patients in the OFF medication state, basal ganglia local field potentials exhibit changes in beta and gamma oscillations that correlate with reduced voluntary movement, manifested as rigidity and akinesia. However, magnetoencephalography and low-resolution electrocorticography (ECoG) studies in Parkinson's patients suggest that changes in sensorimotor cortical oscillations differ from those of the basal ganglia. To more clearly define the role of sensorimotor cortex oscillatory activity in Parkinson's, we performed intraoperative, high-resolution (4 mm spacing) ECoG recordings in 10 Parkinson's patients (2 females, ages 47-72) undergoing deep brain stimulation (DBS) lead placement in the awake, OFF medication state. We analyzed ECoG potentials during a computer-controlled reaching task designed to separate movement preparation from movement execution and compared findings to similar invasive recordings in eight patients with essential tremor (3 females, ages 59-78), a condition not associated with rigidity or akinesia. We show that (1) cortical beta spectral power at rest does not differ between Parkinson's and essential tremor patients (p = 0.85), (2) early motor preparation in Parkinson's patients in the OFF medication state is associated with a larger beta desynchronization compared to patients with essential tremor (p = 0.0061), and (3) cortical broadband gamma power is elevated in Parkinson's patients compared to essential tremor patients during both rest and task recordings (p = 0.004). Our findings suggest an oscillatory profile in sensorimotor cortex of Parkinson's patients that, in contrast to the basal ganglia, may act to promote movement to oppose the anti-kinetic bias of the dopamine-depleted state.

No MeSH data available.


Related in: MedlinePlus