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Frequency-dependent changes in the amplitude of low-frequency fluctuations in internet gaming disorder.

Lin X, Jia X, Zang YF, Dong G - Front Psychol (2015)

Bottom Line: Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus.Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus.These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Zhejiang Normal University, Jinhua China ; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing China.

ABSTRACT
Neuroimaging studies have revealed that the task-related functional brain activities are impaired in internet gaming disorder (IGD) subjects. However, little is known about the alternations in spontaneous brain activities about them. Recent studies have proposed that the brain activities of different frequency ranges are generated by different nervous activities and have different physiological and psychological functions. Thus, in this study, we set to explore the spontaneous brain activities in IGD subjects by measuring the fractional amplitude of low-frequency fluctuation (fALFF), to investigate band-specific changes of resting-state fALFF. We subdivided the frequency range into five bands based on literatures. Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus. Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus. Those brain regions are proved related to the executive function and decision-making. These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.

No MeSH data available.


Related in: MedlinePlus

Reverse pattern in cerebellum and the lingual gyrus at different bands in IGD. The red and blue rectangle represented IGD subjects and healthy controls, respectively. The full frequency band (0–0.25 Hz) was divided into five bands. They were displayed in (A,B) [slow-6 (0–0.01 Hz), slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), slow-3 (0.073–0.198 Hz), and slow-2 (0.198–0.25 Hz)]. (C) revealed the reversed correlation between the fALFF of the cerebellum and the severity of IGD for different frequency (slow-2: r = -0.305, p = 0.028; slow-6: r = 0.277, p = 0.046), (D) revealed the reversed correlation between the fALFF of the lingual cyrus and the severity of IGD for different frequency (slow-2: r = 0.277, p = 0.016; slow-6: r = -0.228, p = 0.104).
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Figure 3: Reverse pattern in cerebellum and the lingual gyrus at different bands in IGD. The red and blue rectangle represented IGD subjects and healthy controls, respectively. The full frequency band (0–0.25 Hz) was divided into five bands. They were displayed in (A,B) [slow-6 (0–0.01 Hz), slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), slow-3 (0.073–0.198 Hz), and slow-2 (0.198–0.25 Hz)]. (C) revealed the reversed correlation between the fALFF of the cerebellum and the severity of IGD for different frequency (slow-2: r = -0.305, p = 0.028; slow-6: r = 0.277, p = 0.046), (D) revealed the reversed correlation between the fALFF of the lingual cyrus and the severity of IGD for different frequency (slow-2: r = 0.277, p = 0.016; slow-6: r = -0.228, p = 0.104).

Mentions: Significant interactions between frequency band and group were observed in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus. The middle frontal gyrus showed increased amplitude values and the middle temporal gyrus showed decreased amplitude values in IGD. In addition, ROI-based analyses presented dynamic alteration of fALFF in the cerebellum and lingual gyrus along with frequency adaption (see Figure 3). In IGD, the cerebellum showed decreased amplitude values in the higher frequency realm (slow-2, slow-3, slow-4) and increased amplitude values in the lower frequency realm (slow-6, see Figure 3A). Conversely, lingual gyrus showed increased amplitude values in the higher frequency realm (slow-2, slow-3) and decreased amplitude values in the lower frequency realm (slow-6, see Figure 3B). These two regions shared a transition point at slow-5 band for the alteration of amplitude.


Frequency-dependent changes in the amplitude of low-frequency fluctuations in internet gaming disorder.

Lin X, Jia X, Zang YF, Dong G - Front Psychol (2015)

Reverse pattern in cerebellum and the lingual gyrus at different bands in IGD. The red and blue rectangle represented IGD subjects and healthy controls, respectively. The full frequency band (0–0.25 Hz) was divided into five bands. They were displayed in (A,B) [slow-6 (0–0.01 Hz), slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), slow-3 (0.073–0.198 Hz), and slow-2 (0.198–0.25 Hz)]. (C) revealed the reversed correlation between the fALFF of the cerebellum and the severity of IGD for different frequency (slow-2: r = -0.305, p = 0.028; slow-6: r = 0.277, p = 0.046), (D) revealed the reversed correlation between the fALFF of the lingual cyrus and the severity of IGD for different frequency (slow-2: r = 0.277, p = 0.016; slow-6: r = -0.228, p = 0.104).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585012&req=5

Figure 3: Reverse pattern in cerebellum and the lingual gyrus at different bands in IGD. The red and blue rectangle represented IGD subjects and healthy controls, respectively. The full frequency band (0–0.25 Hz) was divided into five bands. They were displayed in (A,B) [slow-6 (0–0.01 Hz), slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), slow-3 (0.073–0.198 Hz), and slow-2 (0.198–0.25 Hz)]. (C) revealed the reversed correlation between the fALFF of the cerebellum and the severity of IGD for different frequency (slow-2: r = -0.305, p = 0.028; slow-6: r = 0.277, p = 0.046), (D) revealed the reversed correlation between the fALFF of the lingual cyrus and the severity of IGD for different frequency (slow-2: r = 0.277, p = 0.016; slow-6: r = -0.228, p = 0.104).
Mentions: Significant interactions between frequency band and group were observed in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus. The middle frontal gyrus showed increased amplitude values and the middle temporal gyrus showed decreased amplitude values in IGD. In addition, ROI-based analyses presented dynamic alteration of fALFF in the cerebellum and lingual gyrus along with frequency adaption (see Figure 3). In IGD, the cerebellum showed decreased amplitude values in the higher frequency realm (slow-2, slow-3, slow-4) and increased amplitude values in the lower frequency realm (slow-6, see Figure 3A). Conversely, lingual gyrus showed increased amplitude values in the higher frequency realm (slow-2, slow-3) and decreased amplitude values in the lower frequency realm (slow-6, see Figure 3B). These two regions shared a transition point at slow-5 band for the alteration of amplitude.

Bottom Line: Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus.Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus.These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Zhejiang Normal University, Jinhua China ; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing China.

ABSTRACT
Neuroimaging studies have revealed that the task-related functional brain activities are impaired in internet gaming disorder (IGD) subjects. However, little is known about the alternations in spontaneous brain activities about them. Recent studies have proposed that the brain activities of different frequency ranges are generated by different nervous activities and have different physiological and psychological functions. Thus, in this study, we set to explore the spontaneous brain activities in IGD subjects by measuring the fractional amplitude of low-frequency fluctuation (fALFF), to investigate band-specific changes of resting-state fALFF. We subdivided the frequency range into five bands based on literatures. Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus. Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus. Those brain regions are proved related to the executive function and decision-making. These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.

No MeSH data available.


Related in: MedlinePlus