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Frequency-dependent changes in the amplitude of low-frequency fluctuations in internet gaming disorder.

Lin X, Jia X, Zang YF, Dong G - Front Psychol (2015)

Bottom Line: Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus.Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus.These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Zhejiang Normal University, Jinhua China ; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing China.

ABSTRACT
Neuroimaging studies have revealed that the task-related functional brain activities are impaired in internet gaming disorder (IGD) subjects. However, little is known about the alternations in spontaneous brain activities about them. Recent studies have proposed that the brain activities of different frequency ranges are generated by different nervous activities and have different physiological and psychological functions. Thus, in this study, we set to explore the spontaneous brain activities in IGD subjects by measuring the fractional amplitude of low-frequency fluctuation (fALFF), to investigate band-specific changes of resting-state fALFF. We subdivided the frequency range into five bands based on literatures. Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus. Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus. Those brain regions are proved related to the executive function and decision-making. These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.

No MeSH data available.


Related in: MedlinePlus

(A) The main effect for group on amplitude of low-frequency fluctuation (ALFF). Brain regions in which the fractional amplitude of low-frequency fluctuation (fALFF) is different between Internet gaming disorder (IGD) and healthy controls. The IGD subjects showed increased ALFF in warm colored brain regions especially the cerebellum, whereas decreased ALFF in cool colored regions including the superior temporal gyrus. Map threshold of multiple comparisons were set at p < 0.05 using AlphaSim correction. (B) The interaction between frequency band and group on fALFF. The results were obtained by a two-way repeated-measures analysis of variance (ANOVA) calculated by AFNI.
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Figure 1: (A) The main effect for group on amplitude of low-frequency fluctuation (ALFF). Brain regions in which the fractional amplitude of low-frequency fluctuation (fALFF) is different between Internet gaming disorder (IGD) and healthy controls. The IGD subjects showed increased ALFF in warm colored brain regions especially the cerebellum, whereas decreased ALFF in cool colored regions including the superior temporal gyrus. Map threshold of multiple comparisons were set at p < 0.05 using AlphaSim correction. (B) The interaction between frequency band and group on fALFF. The results were obtained by a two-way repeated-measures analysis of variance (ANOVA) calculated by AFNI.

Mentions: Main effects from the two-way repeated-measures ANOVA were shown in Figure 1, Tables 1 and 2. We used Alphasim correction for the multiple comparisons in imaging data. The corrected p < 0.05 corresponds to a combination of uncorrected p < 0.05 and cluster size >248 mm3). ROI based correlation analysis was carried out between fALFF values and the severity of IGD (scores of IAT). The cerebellum showed significant negative correlation with IGD severity (slow-4: r = -0.487, p = 0.000; slow-5: r = -0.485, p = 0.000; see Figure 2C). The coordinate of ROI was defined by the activation peak of the survived cluster. The radius of ROI is 4 mm, and is made by the software REST2.


Frequency-dependent changes in the amplitude of low-frequency fluctuations in internet gaming disorder.

Lin X, Jia X, Zang YF, Dong G - Front Psychol (2015)

(A) The main effect for group on amplitude of low-frequency fluctuation (ALFF). Brain regions in which the fractional amplitude of low-frequency fluctuation (fALFF) is different between Internet gaming disorder (IGD) and healthy controls. The IGD subjects showed increased ALFF in warm colored brain regions especially the cerebellum, whereas decreased ALFF in cool colored regions including the superior temporal gyrus. Map threshold of multiple comparisons were set at p < 0.05 using AlphaSim correction. (B) The interaction between frequency band and group on fALFF. The results were obtained by a two-way repeated-measures analysis of variance (ANOVA) calculated by AFNI.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4585012&req=5

Figure 1: (A) The main effect for group on amplitude of low-frequency fluctuation (ALFF). Brain regions in which the fractional amplitude of low-frequency fluctuation (fALFF) is different between Internet gaming disorder (IGD) and healthy controls. The IGD subjects showed increased ALFF in warm colored brain regions especially the cerebellum, whereas decreased ALFF in cool colored regions including the superior temporal gyrus. Map threshold of multiple comparisons were set at p < 0.05 using AlphaSim correction. (B) The interaction between frequency band and group on fALFF. The results were obtained by a two-way repeated-measures analysis of variance (ANOVA) calculated by AFNI.
Mentions: Main effects from the two-way repeated-measures ANOVA were shown in Figure 1, Tables 1 and 2. We used Alphasim correction for the multiple comparisons in imaging data. The corrected p < 0.05 corresponds to a combination of uncorrected p < 0.05 and cluster size >248 mm3). ROI based correlation analysis was carried out between fALFF values and the severity of IGD (scores of IAT). The cerebellum showed significant negative correlation with IGD severity (slow-4: r = -0.487, p = 0.000; slow-5: r = -0.485, p = 0.000; see Figure 2C). The coordinate of ROI was defined by the activation peak of the survived cluster. The radius of ROI is 4 mm, and is made by the software REST2.

Bottom Line: Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus.Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus.These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Zhejiang Normal University, Jinhua China ; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing China.

ABSTRACT
Neuroimaging studies have revealed that the task-related functional brain activities are impaired in internet gaming disorder (IGD) subjects. However, little is known about the alternations in spontaneous brain activities about them. Recent studies have proposed that the brain activities of different frequency ranges are generated by different nervous activities and have different physiological and psychological functions. Thus, in this study, we set to explore the spontaneous brain activities in IGD subjects by measuring the fractional amplitude of low-frequency fluctuation (fALFF), to investigate band-specific changes of resting-state fALFF. We subdivided the frequency range into five bands based on literatures. Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus. Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus. Those brain regions are proved related to the executive function and decision-making. These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.

No MeSH data available.


Related in: MedlinePlus