Limits...
Modulation of autonomic activity in neurological conditions: Epilepsy and Tourette Syndrome.

Nagai Y - Front Neurosci (2015)

Bottom Line: Investigation is more limited in Tourette Syndrome.The role of the autonomic nervous system in the generation and prevention of epileptic seizures is largely overlooked.This approach also takes advantage of the current practical opportunity to utilize growing digital health technology.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Medicine, Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex Brighton, UK.

ABSTRACT
This manuscript considers the central but neglected role of the autonomic nervous system in the expression and control of seizures in epilepsy (small) and tics in Tourette Syndrome (TS). In epilepsy, consideration of autonomic involvement is typically confined to differential diagnoses (e.g., syncope), or in relation to Sudden Unexpected Death in Epilepsy (SUDEP). Investigation is more limited in Tourette Syndrome. The role of the autonomic nervous system in the generation and prevention of epileptic seizures is largely overlooked. Emotional stimuli such as anxiety and stress are potent causes of seizures and tic activity in epilepsy and TS, respectively. This manuscript will describe a possible neural mechanism by which afferent autonomic projections linked to cognition and behavior influence central thalamo-cortical regulation, which appears to be an important means for controlling both seizure and tic activity. It also summarizes the link between the integrity of the default mode network and autonomic regulation in patients with epilepsy as well as the link between impaired motor control and autonomic regulation in patients with TS. Two neurological conditions; epilepsy and TS were chosen, as seizures and tics represent parameters that can be easily measured to investigate influences of autonomic functions. The EDA biofeedback approach is anticipated to gain a strong position within the next generation of treatment for epilepsy, as a non-invasive technique with minimal side effects. This approach also takes advantage of the current practical opportunity to utilize growing digital health technology.

No MeSH data available.


Related in: MedlinePlus

Model of biofeedback intervention to behavioral modulation and seizure suppression. The model describes biofeedback intervention to alter psychological and neural dynamics influencing seizure generation.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4584996&req=5

Figure 2: Model of biofeedback intervention to behavioral modulation and seizure suppression. The model describes biofeedback intervention to alter psychological and neural dynamics influencing seizure generation.

Mentions: Similarly, psychological influences and autonomic dysfunction may also play a role in the expression of tics in TS, through thalamo-cortical-striatal dysregulation [known to underlie tic activity (Wang et al., 2011)]. Attempting to alter these complex dynamics by modifying physiological and psychological processes may represent a valuable treatment option (Figure 2).


Modulation of autonomic activity in neurological conditions: Epilepsy and Tourette Syndrome.

Nagai Y - Front Neurosci (2015)

Model of biofeedback intervention to behavioral modulation and seizure suppression. The model describes biofeedback intervention to alter psychological and neural dynamics influencing seizure generation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4584996&req=5

Figure 2: Model of biofeedback intervention to behavioral modulation and seizure suppression. The model describes biofeedback intervention to alter psychological and neural dynamics influencing seizure generation.
Mentions: Similarly, psychological influences and autonomic dysfunction may also play a role in the expression of tics in TS, through thalamo-cortical-striatal dysregulation [known to underlie tic activity (Wang et al., 2011)]. Attempting to alter these complex dynamics by modifying physiological and psychological processes may represent a valuable treatment option (Figure 2).

Bottom Line: Investigation is more limited in Tourette Syndrome.The role of the autonomic nervous system in the generation and prevention of epileptic seizures is largely overlooked.This approach also takes advantage of the current practical opportunity to utilize growing digital health technology.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Medicine, Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex Brighton, UK.

ABSTRACT
This manuscript considers the central but neglected role of the autonomic nervous system in the expression and control of seizures in epilepsy (small) and tics in Tourette Syndrome (TS). In epilepsy, consideration of autonomic involvement is typically confined to differential diagnoses (e.g., syncope), or in relation to Sudden Unexpected Death in Epilepsy (SUDEP). Investigation is more limited in Tourette Syndrome. The role of the autonomic nervous system in the generation and prevention of epileptic seizures is largely overlooked. Emotional stimuli such as anxiety and stress are potent causes of seizures and tic activity in epilepsy and TS, respectively. This manuscript will describe a possible neural mechanism by which afferent autonomic projections linked to cognition and behavior influence central thalamo-cortical regulation, which appears to be an important means for controlling both seizure and tic activity. It also summarizes the link between the integrity of the default mode network and autonomic regulation in patients with epilepsy as well as the link between impaired motor control and autonomic regulation in patients with TS. Two neurological conditions; epilepsy and TS were chosen, as seizures and tics represent parameters that can be easily measured to investigate influences of autonomic functions. The EDA biofeedback approach is anticipated to gain a strong position within the next generation of treatment for epilepsy, as a non-invasive technique with minimal side effects. This approach also takes advantage of the current practical opportunity to utilize growing digital health technology.

No MeSH data available.


Related in: MedlinePlus