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Effects of a Macro-Nutrient Preload on Type 2 Diabetic Patients.

Li CJ, Norstedt G, Hu ZG, Yu P, Li DQ, Li J, Yu Q, Sederholm M, Yu DM - Front Endocrinol (Lausanne) (2015)

Bottom Line: The dietary intervention significantly influenced several metabolic parameters compared to base line.Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast (p < 0.05).Approximately half of the study group also displayed reduced BW.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Hormone and Development (Ministry of Health), Department of Endocrinology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Institute of Endocrinology, Metabolic Disease Hospital, Tianjin Medical University , Tianjin , China.

ABSTRACT

Aims: Macro-nutrient preloads given 30 min before regular meals may improve metabolism. The aim was to investigate how type 2 diabetic patients react to a preload consisting of a blend of macro-nutrients with a low-glycemic index (Inzone Preload(®)).

Methods: In a before-after study design, 30 subjects with type 2 diabetes mellitus (T2DM) were enrolled in a 12-week program. All subjects were given Inzone Preload (43% proteins, 29% carbohydrates, 10% lipids, and 9% fibers, 71 kcal), 30 min before each meal during 12 weeks. Fasting glucose and postprandial 2 h glucose were monitored every second week. Body weight (BW) and waist circumference were measured each month. Fasting plasma glucose, glycosylated hemoglobin, serum lipids, fasting insulin, C-reactive protein, and homeostasis model assessment were evaluated before and after the intervention. Subjective appetite was monitored using visual analogue scales after the Inzone Preload.

Results: The dietary intervention significantly influenced several metabolic parameters compared to base line. Inzone Preload treatment reduced mean postprandial plasma glucose levels (12.2 ± 1.2 vs. 10.5 ± 2.0 mmol/L), HbA1c (7.4 ± 0.3 vs. 7.1 ± 0.2%), mean total cholesterol (4.8 ± 0.9 vs. 4.3 ± 0.8 mmol/L), low-density lipoprotein cholesterol (2.8 ± 0.6 vs. 2.5 ± 0.4 mmol/L), and CRP (1.5 ± 1.4 vs. 0.7 ± 0.7 mg/L). BW loss of more than 3% was seen in 13 participants (43%). Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast (p < 0.05). No significant changes in fasting blood glucose, high-density lipoprotein and total triacylglycerol, HOMA-IR, and HOMA-β were observed.

Conclusion: A macro-nutrient preload treatment reduces postprandial glucose, inflammatory markers, and serum lipids in patients with T2DM. Approximately half of the study group also displayed reduced BW.

No MeSH data available.


Related in: MedlinePlus

Changes in postprandial glucose throughout the study. A lowering of 2 h-BG of ≥1.9 mmol/L was used as a cut-off separating 67% of the subjects as responders. Responders (n = 19) are indicated with -◆-. Non-responders (n = 8) are indicated with -▲-.
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Figure 2: Changes in postprandial glucose throughout the study. A lowering of 2 h-BG of ≥1.9 mmol/L was used as a cut-off separating 67% of the subjects as responders. Responders (n = 19) are indicated with -◆-. Non-responders (n = 8) are indicated with -▲-.

Mentions: It was clear from the data above that the response to Inzone treatment varied between individuals. In an attempt to analyze data further, we attempted to separate individuals responding from non-responders using 2 h-BG measurements. A lowering of 2 h-BG ≥1.9 mmol/L (22) was used as a cut-off and this separated 67% of the subjects into one group termed responders (n = 19) and another group called non-responders (n = 8) (Table 2). In the responding group, reduction of 2 h-BG was near maximal at week 4, with modest progressive reductions and no apparent plateau observed through week 12 (Figure 2). In the responding group, a reduced BW was seen in 13 patients after 8 weeks and this was maintained during the study (Supplement S2 in Supplementary Material). A multiple regression analysis was performed to evaluate the independent factors that might predict 2 h-BG changes. A weak but significant linear correlation was found that shorter duration of diabetes, higher HOMA-β level and greater reduction in BW were significantly correlated with 2 h-BG reduction, but BMI, baseline HbA1c were insignificant factors (Table 3).


Effects of a Macro-Nutrient Preload on Type 2 Diabetic Patients.

Li CJ, Norstedt G, Hu ZG, Yu P, Li DQ, Li J, Yu Q, Sederholm M, Yu DM - Front Endocrinol (Lausanne) (2015)

Changes in postprandial glucose throughout the study. A lowering of 2 h-BG of ≥1.9 mmol/L was used as a cut-off separating 67% of the subjects as responders. Responders (n = 19) are indicated with -◆-. Non-responders (n = 8) are indicated with -▲-.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4584965&req=5

Figure 2: Changes in postprandial glucose throughout the study. A lowering of 2 h-BG of ≥1.9 mmol/L was used as a cut-off separating 67% of the subjects as responders. Responders (n = 19) are indicated with -◆-. Non-responders (n = 8) are indicated with -▲-.
Mentions: It was clear from the data above that the response to Inzone treatment varied between individuals. In an attempt to analyze data further, we attempted to separate individuals responding from non-responders using 2 h-BG measurements. A lowering of 2 h-BG ≥1.9 mmol/L (22) was used as a cut-off and this separated 67% of the subjects into one group termed responders (n = 19) and another group called non-responders (n = 8) (Table 2). In the responding group, reduction of 2 h-BG was near maximal at week 4, with modest progressive reductions and no apparent plateau observed through week 12 (Figure 2). In the responding group, a reduced BW was seen in 13 patients after 8 weeks and this was maintained during the study (Supplement S2 in Supplementary Material). A multiple regression analysis was performed to evaluate the independent factors that might predict 2 h-BG changes. A weak but significant linear correlation was found that shorter duration of diabetes, higher HOMA-β level and greater reduction in BW were significantly correlated with 2 h-BG reduction, but BMI, baseline HbA1c were insignificant factors (Table 3).

Bottom Line: The dietary intervention significantly influenced several metabolic parameters compared to base line.Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast (p < 0.05).Approximately half of the study group also displayed reduced BW.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Hormone and Development (Ministry of Health), Department of Endocrinology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Institute of Endocrinology, Metabolic Disease Hospital, Tianjin Medical University , Tianjin , China.

ABSTRACT

Aims: Macro-nutrient preloads given 30 min before regular meals may improve metabolism. The aim was to investigate how type 2 diabetic patients react to a preload consisting of a blend of macro-nutrients with a low-glycemic index (Inzone Preload(®)).

Methods: In a before-after study design, 30 subjects with type 2 diabetes mellitus (T2DM) were enrolled in a 12-week program. All subjects were given Inzone Preload (43% proteins, 29% carbohydrates, 10% lipids, and 9% fibers, 71 kcal), 30 min before each meal during 12 weeks. Fasting glucose and postprandial 2 h glucose were monitored every second week. Body weight (BW) and waist circumference were measured each month. Fasting plasma glucose, glycosylated hemoglobin, serum lipids, fasting insulin, C-reactive protein, and homeostasis model assessment were evaluated before and after the intervention. Subjective appetite was monitored using visual analogue scales after the Inzone Preload.

Results: The dietary intervention significantly influenced several metabolic parameters compared to base line. Inzone Preload treatment reduced mean postprandial plasma glucose levels (12.2 ± 1.2 vs. 10.5 ± 2.0 mmol/L), HbA1c (7.4 ± 0.3 vs. 7.1 ± 0.2%), mean total cholesterol (4.8 ± 0.9 vs. 4.3 ± 0.8 mmol/L), low-density lipoprotein cholesterol (2.8 ± 0.6 vs. 2.5 ± 0.4 mmol/L), and CRP (1.5 ± 1.4 vs. 0.7 ± 0.7 mg/L). BW loss of more than 3% was seen in 13 participants (43%). Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast (p < 0.05). No significant changes in fasting blood glucose, high-density lipoprotein and total triacylglycerol, HOMA-IR, and HOMA-β were observed.

Conclusion: A macro-nutrient preload treatment reduces postprandial glucose, inflammatory markers, and serum lipids in patients with T2DM. Approximately half of the study group also displayed reduced BW.

No MeSH data available.


Related in: MedlinePlus