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Effects of a Macro-Nutrient Preload on Type 2 Diabetic Patients.

Li CJ, Norstedt G, Hu ZG, Yu P, Li DQ, Li J, Yu Q, Sederholm M, Yu DM - Front Endocrinol (Lausanne) (2015)

Bottom Line: The dietary intervention significantly influenced several metabolic parameters compared to base line.Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast (p < 0.05).Approximately half of the study group also displayed reduced BW.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Hormone and Development (Ministry of Health), Department of Endocrinology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Institute of Endocrinology, Metabolic Disease Hospital, Tianjin Medical University , Tianjin , China.

ABSTRACT

Aims: Macro-nutrient preloads given 30 min before regular meals may improve metabolism. The aim was to investigate how type 2 diabetic patients react to a preload consisting of a blend of macro-nutrients with a low-glycemic index (Inzone Preload(®)).

Methods: In a before-after study design, 30 subjects with type 2 diabetes mellitus (T2DM) were enrolled in a 12-week program. All subjects were given Inzone Preload (43% proteins, 29% carbohydrates, 10% lipids, and 9% fibers, 71 kcal), 30 min before each meal during 12 weeks. Fasting glucose and postprandial 2 h glucose were monitored every second week. Body weight (BW) and waist circumference were measured each month. Fasting plasma glucose, glycosylated hemoglobin, serum lipids, fasting insulin, C-reactive protein, and homeostasis model assessment were evaluated before and after the intervention. Subjective appetite was monitored using visual analogue scales after the Inzone Preload.

Results: The dietary intervention significantly influenced several metabolic parameters compared to base line. Inzone Preload treatment reduced mean postprandial plasma glucose levels (12.2 ± 1.2 vs. 10.5 ± 2.0 mmol/L), HbA1c (7.4 ± 0.3 vs. 7.1 ± 0.2%), mean total cholesterol (4.8 ± 0.9 vs. 4.3 ± 0.8 mmol/L), low-density lipoprotein cholesterol (2.8 ± 0.6 vs. 2.5 ± 0.4 mmol/L), and CRP (1.5 ± 1.4 vs. 0.7 ± 0.7 mg/L). BW loss of more than 3% was seen in 13 participants (43%). Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast (p < 0.05). No significant changes in fasting blood glucose, high-density lipoprotein and total triacylglycerol, HOMA-IR, and HOMA-β were observed.

Conclusion: A macro-nutrient preload treatment reduces postprandial glucose, inflammatory markers, and serum lipids in patients with T2DM. Approximately half of the study group also displayed reduced BW.

No MeSH data available.


Related in: MedlinePlus

(A,B) Effects of preload on satiety (A) and hunger (B). Mean visual analog scale (VAS) subjective scores for satiety (A) and hunger (B) for habitual breakfast. Habitual breakfast is indicated by -◆- and Preload before habitual breakfast by -▲-. Inserts: area under the curve histograms for 0–120 min are shown, habitual breakfast (open bars), and preload before habitual breakfast (filled bars). The time-by-interaction was statistically significant for satiety (p < 0.05, 0–120 min).
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Figure 1: (A,B) Effects of preload on satiety (A) and hunger (B). Mean visual analog scale (VAS) subjective scores for satiety (A) and hunger (B) for habitual breakfast. Habitual breakfast is indicated by -◆- and Preload before habitual breakfast by -▲-. Inserts: area under the curve histograms for 0–120 min are shown, habitual breakfast (open bars), and preload before habitual breakfast (filled bars). The time-by-interaction was statistically significant for satiety (p < 0.05, 0–120 min).

Mentions: The Inzone Preload intervention resulted in a significantly higher postprandial satiety at the onset of the meal (at time point 0 min, 30 min after preload was given) (p = 0.045) and 30 min (p = 0.042) after the habitual breakfast (Figure 1A). The AUCs for satiety were not significantly larger at any time after Inzone Preload than habitual breakfast. Regarding the questions on aspects of hunger, subjects reported a lower level of hunger after the Inzone Preload than after the habitual breakfast at 0 min (p = 0.047) and after 30 min (p = 0.352). No differences were observed in the AUCs for hunger (p = 0.241) (Figure 1B).


Effects of a Macro-Nutrient Preload on Type 2 Diabetic Patients.

Li CJ, Norstedt G, Hu ZG, Yu P, Li DQ, Li J, Yu Q, Sederholm M, Yu DM - Front Endocrinol (Lausanne) (2015)

(A,B) Effects of preload on satiety (A) and hunger (B). Mean visual analog scale (VAS) subjective scores for satiety (A) and hunger (B) for habitual breakfast. Habitual breakfast is indicated by -◆- and Preload before habitual breakfast by -▲-. Inserts: area under the curve histograms for 0–120 min are shown, habitual breakfast (open bars), and preload before habitual breakfast (filled bars). The time-by-interaction was statistically significant for satiety (p < 0.05, 0–120 min).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4584965&req=5

Figure 1: (A,B) Effects of preload on satiety (A) and hunger (B). Mean visual analog scale (VAS) subjective scores for satiety (A) and hunger (B) for habitual breakfast. Habitual breakfast is indicated by -◆- and Preload before habitual breakfast by -▲-. Inserts: area under the curve histograms for 0–120 min are shown, habitual breakfast (open bars), and preload before habitual breakfast (filled bars). The time-by-interaction was statistically significant for satiety (p < 0.05, 0–120 min).
Mentions: The Inzone Preload intervention resulted in a significantly higher postprandial satiety at the onset of the meal (at time point 0 min, 30 min after preload was given) (p = 0.045) and 30 min (p = 0.042) after the habitual breakfast (Figure 1A). The AUCs for satiety were not significantly larger at any time after Inzone Preload than habitual breakfast. Regarding the questions on aspects of hunger, subjects reported a lower level of hunger after the Inzone Preload than after the habitual breakfast at 0 min (p = 0.047) and after 30 min (p = 0.352). No differences were observed in the AUCs for hunger (p = 0.241) (Figure 1B).

Bottom Line: The dietary intervention significantly influenced several metabolic parameters compared to base line.Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast (p < 0.05).Approximately half of the study group also displayed reduced BW.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Hormone and Development (Ministry of Health), Department of Endocrinology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Institute of Endocrinology, Metabolic Disease Hospital, Tianjin Medical University , Tianjin , China.

ABSTRACT

Aims: Macro-nutrient preloads given 30 min before regular meals may improve metabolism. The aim was to investigate how type 2 diabetic patients react to a preload consisting of a blend of macro-nutrients with a low-glycemic index (Inzone Preload(®)).

Methods: In a before-after study design, 30 subjects with type 2 diabetes mellitus (T2DM) were enrolled in a 12-week program. All subjects were given Inzone Preload (43% proteins, 29% carbohydrates, 10% lipids, and 9% fibers, 71 kcal), 30 min before each meal during 12 weeks. Fasting glucose and postprandial 2 h glucose were monitored every second week. Body weight (BW) and waist circumference were measured each month. Fasting plasma glucose, glycosylated hemoglobin, serum lipids, fasting insulin, C-reactive protein, and homeostasis model assessment were evaluated before and after the intervention. Subjective appetite was monitored using visual analogue scales after the Inzone Preload.

Results: The dietary intervention significantly influenced several metabolic parameters compared to base line. Inzone Preload treatment reduced mean postprandial plasma glucose levels (12.2 ± 1.2 vs. 10.5 ± 2.0 mmol/L), HbA1c (7.4 ± 0.3 vs. 7.1 ± 0.2%), mean total cholesterol (4.8 ± 0.9 vs. 4.3 ± 0.8 mmol/L), low-density lipoprotein cholesterol (2.8 ± 0.6 vs. 2.5 ± 0.4 mmol/L), and CRP (1.5 ± 1.4 vs. 0.7 ± 0.7 mg/L). BW loss of more than 3% was seen in 13 participants (43%). Feelings of satiety were significantly higher after Inzone Preload than after habitual breakfast (p < 0.05). No significant changes in fasting blood glucose, high-density lipoprotein and total triacylglycerol, HOMA-IR, and HOMA-β were observed.

Conclusion: A macro-nutrient preload treatment reduces postprandial glucose, inflammatory markers, and serum lipids in patients with T2DM. Approximately half of the study group also displayed reduced BW.

No MeSH data available.


Related in: MedlinePlus