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Designing and testing regenerative pulp treatment strategies: modeling the transdentinal transport mechanisms.

Passos AD, Mouza AA, Paras SV, Gogos C, Tziafas D - Front Physiol (2015)

Bottom Line: The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research.The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule.In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, Aristotle University of Thessaloniki Thessaloniki, Greece.

ABSTRACT
The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research. The development of a model that simulates the transdentinal flow and the mass transfer mechanisms is of prime importance in terms of achieving the objectives of developing more effective treatment modalities in restorative dentistry. The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule. The transport rate of biological molecules has been investigated using a validated CFD code. In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

No MeSH data available.


(A) Effect of the initial substance concentration on the diffusion characteristics [t(1, 2) time needed to reach a specified concentration value at the pulp] and (B) Effect of the molecular size on the diffusion characteristics.
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Figure 5: (A) Effect of the initial substance concentration on the diffusion characteristics [t(1, 2) time needed to reach a specified concentration value at the pulp] and (B) Effect of the molecular size on the diffusion characteristics.

Mentions: The diffusion of a substance similar to the therapeutic agent BMP-7, through a dentinal tubule under different values of initial concentration has been studied. Figure 5A, which presents the therapeutic agent concentration at the bottom of the dentinal tubule, i.e., at the dentin-pulp junction, as a function of time, demonstrates the effect of initial substance concentration on the concentration change. Figure 5B shows the effect of the type of substance, i.e., its molecular size, on the concentration change at the pulpal area.


Designing and testing regenerative pulp treatment strategies: modeling the transdentinal transport mechanisms.

Passos AD, Mouza AA, Paras SV, Gogos C, Tziafas D - Front Physiol (2015)

(A) Effect of the initial substance concentration on the diffusion characteristics [t(1, 2) time needed to reach a specified concentration value at the pulp] and (B) Effect of the molecular size on the diffusion characteristics.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4584931&req=5

Figure 5: (A) Effect of the initial substance concentration on the diffusion characteristics [t(1, 2) time needed to reach a specified concentration value at the pulp] and (B) Effect of the molecular size on the diffusion characteristics.
Mentions: The diffusion of a substance similar to the therapeutic agent BMP-7, through a dentinal tubule under different values of initial concentration has been studied. Figure 5A, which presents the therapeutic agent concentration at the bottom of the dentinal tubule, i.e., at the dentin-pulp junction, as a function of time, demonstrates the effect of initial substance concentration on the concentration change. Figure 5B shows the effect of the type of substance, i.e., its molecular size, on the concentration change at the pulpal area.

Bottom Line: The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research.The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule.In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, Aristotle University of Thessaloniki Thessaloniki, Greece.

ABSTRACT
The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research. The development of a model that simulates the transdentinal flow and the mass transfer mechanisms is of prime importance in terms of achieving the objectives of developing more effective treatment modalities in restorative dentistry. The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule. The transport rate of biological molecules has been investigated using a validated CFD code. In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

No MeSH data available.