Limits...
Designing and testing regenerative pulp treatment strategies: modeling the transdentinal transport mechanisms.

Passos AD, Mouza AA, Paras SV, Gogos C, Tziafas D - Front Physiol (2015)

Bottom Line: The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research.The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule.In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, Aristotle University of Thessaloniki Thessaloniki, Greece.

ABSTRACT
The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research. The development of a model that simulates the transdentinal flow and the mass transfer mechanisms is of prime importance in terms of achieving the objectives of developing more effective treatment modalities in restorative dentistry. The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule. The transport rate of biological molecules has been investigated using a validated CFD code. In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

No MeSH data available.


Comparison of CFD data with the corresponding results from the LIF technique: (A) mass concentration distribution inside the capillary after t = 4 h and (B) mass concentration values for x/L = 0.067 and 0.330; error bars: ±10%.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4584931&req=5

Figure 3: Comparison of CFD data with the corresponding results from the LIF technique: (A) mass concentration distribution inside the capillary after t = 4 h and (B) mass concentration values for x/L = 0.067 and 0.330; error bars: ±10%.

Mentions: In Figure 3A a typical comparison of CFD data with the corresponding results from the μ-LIF technique is presented concerning the concentration inside the channel after t = 4 h. The dashed line represents the calculated final concentration value Ct inside the capillary for t = 8. In Figure 3B the two methods are compared with respect to the temporal concentration variation at two locations inside the capillary (x/L = 0.067 and 0.330).


Designing and testing regenerative pulp treatment strategies: modeling the transdentinal transport mechanisms.

Passos AD, Mouza AA, Paras SV, Gogos C, Tziafas D - Front Physiol (2015)

Comparison of CFD data with the corresponding results from the LIF technique: (A) mass concentration distribution inside the capillary after t = 4 h and (B) mass concentration values for x/L = 0.067 and 0.330; error bars: ±10%.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4584931&req=5

Figure 3: Comparison of CFD data with the corresponding results from the LIF technique: (A) mass concentration distribution inside the capillary after t = 4 h and (B) mass concentration values for x/L = 0.067 and 0.330; error bars: ±10%.
Mentions: In Figure 3A a typical comparison of CFD data with the corresponding results from the μ-LIF technique is presented concerning the concentration inside the channel after t = 4 h. The dashed line represents the calculated final concentration value Ct inside the capillary for t = 8. In Figure 3B the two methods are compared with respect to the temporal concentration variation at two locations inside the capillary (x/L = 0.067 and 0.330).

Bottom Line: The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research.The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule.In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, Aristotle University of Thessaloniki Thessaloniki, Greece.

ABSTRACT
The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research. The development of a model that simulates the transdentinal flow and the mass transfer mechanisms is of prime importance in terms of achieving the objectives of developing more effective treatment modalities in restorative dentistry. The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule. The transport rate of biological molecules has been investigated using a validated CFD code. In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

No MeSH data available.