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The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ - J Crohns Colitis (2015)

Bottom Line: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos.The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001].Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].

View Article: PubMed Central - PubMed

Affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK simon.travis@ndm.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Distribution of rectal bleeding [RB] and stool frequency [SF] items across UCEIS levels. A: When UCEIS ≤ 1, no RB > 95% of the time; when UCEIS ≥ 6, some RB 95% of the time. B: When UCEIS ≤ 1, no increase in SF ~ 90% of the time; when UCEIS ≥ 5, increase in SF 95% of the time.
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Figure 5: Distribution of rectal bleeding [RB] and stool frequency [SF] items across UCEIS levels. A: When UCEIS ≤ 1, no RB > 95% of the time; when UCEIS ≥ 6, some RB 95% of the time. B: When UCEIS ≤ 1, no increase in SF ~ 90% of the time; when UCEIS ≥ 5, increase in SF 95% of the time.

Mentions: Scores for RB and SF items showed a clear correlation with endoscopic severity as measured by the UCEIS [Figure 5]. When the UCEIS score was ≥ 5, then RB or an increase in SF was present at least 95% of the time. Such patient-reported symptoms inform clinical thresholds of the UCEIS for evaluating its relationship to outcomes, which are relevant to regulatory assessment.


The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ - J Crohns Colitis (2015)

Distribution of rectal bleeding [RB] and stool frequency [SF] items across UCEIS levels. A: When UCEIS ≤ 1, no RB > 95% of the time; when UCEIS ≥ 6, some RB 95% of the time. B: When UCEIS ≤ 1, no increase in SF ~ 90% of the time; when UCEIS ≥ 5, increase in SF 95% of the time.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4584567&req=5

Figure 5: Distribution of rectal bleeding [RB] and stool frequency [SF] items across UCEIS levels. A: When UCEIS ≤ 1, no RB > 95% of the time; when UCEIS ≥ 6, some RB 95% of the time. B: When UCEIS ≤ 1, no increase in SF ~ 90% of the time; when UCEIS ≥ 5, increase in SF 95% of the time.
Mentions: Scores for RB and SF items showed a clear correlation with endoscopic severity as measured by the UCEIS [Figure 5]. When the UCEIS score was ≥ 5, then RB or an increase in SF was present at least 95% of the time. Such patient-reported symptoms inform clinical thresholds of the UCEIS for evaluating its relationship to outcomes, which are relevant to regulatory assessment.

Bottom Line: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos.The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001].Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].

View Article: PubMed Central - PubMed

Affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK simon.travis@ndm.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus