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The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ - J Crohns Colitis (2015)

Bottom Line: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos.The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001].Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].

View Article: PubMed Central - PubMed

Affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK simon.travis@ndm.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Standard deviations for the blinded, virtual central reader groups [CRGs] and individual, blinded [‘standard’] readers across the range of UCEIS scores [0–8] represented in the main evaluation set of 40 videos.
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Figure 4: Standard deviations for the blinded, virtual central reader groups [CRGs] and individual, blinded [‘standard’] readers across the range of UCEIS scores [0–8] represented in the main evaluation set of 40 videos.

Mentions: The median SD was significantly lower in the blinded, virtual CRG than for ‘standard’ readers [0.54 vs 0.95, respectively; p < 0.001]. This was most apparent in videos representing UCEIS scores between 3 and 5, most likely to represent the spectrum mild or moderate endoscopic disease severity [Figure 4], which has substantial implications for clinical trials. The SD was least and also most similar at the extremes of the UCEIS range [≤ 2 and ≥ 6], which implies that the UCEIS has least variance for defining remission or severe endoscopic activity.


The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ - J Crohns Colitis (2015)

Standard deviations for the blinded, virtual central reader groups [CRGs] and individual, blinded [‘standard’] readers across the range of UCEIS scores [0–8] represented in the main evaluation set of 40 videos.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4584567&req=5

Figure 4: Standard deviations for the blinded, virtual central reader groups [CRGs] and individual, blinded [‘standard’] readers across the range of UCEIS scores [0–8] represented in the main evaluation set of 40 videos.
Mentions: The median SD was significantly lower in the blinded, virtual CRG than for ‘standard’ readers [0.54 vs 0.95, respectively; p < 0.001]. This was most apparent in videos representing UCEIS scores between 3 and 5, most likely to represent the spectrum mild or moderate endoscopic disease severity [Figure 4], which has substantial implications for clinical trials. The SD was least and also most similar at the extremes of the UCEIS range [≤ 2 and ≥ 6], which implies that the UCEIS has least variance for defining remission or severe endoscopic activity.

Bottom Line: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos.The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001].Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].

View Article: PubMed Central - PubMed

Affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK simon.travis@ndm.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus