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The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ - J Crohns Colitis (2015)

Bottom Line: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos.The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001].Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].

View Article: PubMed Central - PubMed

Affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK simon.travis@ndm.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Standard deviations for blinded and unblinded groups for the main evaluation set of 40 videos.
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Figure 3: Standard deviations for blinded and unblinded groups for the main evaluation set of 40 videos.

Mentions: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 videos in the main analysis set [Wilcoxon rank sum tests with Holm’s multiplicity adjustment, all p-values ≥ 0.05] [Figure 2A]. There was one video [severe UC recorded before colectomy] for which the VAS score was significantly higher in the blinded group [p = 0.045] [Figure 2B]. There were no systematic differences found in the UCEIS SDs between the blinded and unblinded groups in the main dataset [median SD 0.94 vs 0.93, respectively; p = 0.97], although as expected, the SD was lowest at the severe end of the video spectrum [Figure 3]. Median correlation between UCEIS and overall severity on the VAS was high in both the blinded [median = 0.899, minimum = 0.80, maximum = 0.967] and unblinded [median = 0.933, minimum = 0.856, maximum = 0.972] groups in the main dataset of 40 videos. The difference between the median correlations, though small [0.034], was statistically significant [p = 0.02]. For the four common control videos, there were no statistically significant differences in UCEIS [p ≥ 0.55] or overall severity scores [p ≥ 0.07] between reader groups.


The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ - J Crohns Colitis (2015)

Standard deviations for blinded and unblinded groups for the main evaluation set of 40 videos.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4584567&req=5

Figure 3: Standard deviations for blinded and unblinded groups for the main evaluation set of 40 videos.
Mentions: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 videos in the main analysis set [Wilcoxon rank sum tests with Holm’s multiplicity adjustment, all p-values ≥ 0.05] [Figure 2A]. There was one video [severe UC recorded before colectomy] for which the VAS score was significantly higher in the blinded group [p = 0.045] [Figure 2B]. There were no systematic differences found in the UCEIS SDs between the blinded and unblinded groups in the main dataset [median SD 0.94 vs 0.93, respectively; p = 0.97], although as expected, the SD was lowest at the severe end of the video spectrum [Figure 3]. Median correlation between UCEIS and overall severity on the VAS was high in both the blinded [median = 0.899, minimum = 0.80, maximum = 0.967] and unblinded [median = 0.933, minimum = 0.856, maximum = 0.972] groups in the main dataset of 40 videos. The difference between the median correlations, though small [0.034], was statistically significant [p = 0.02]. For the four common control videos, there were no statistically significant differences in UCEIS [p ≥ 0.55] or overall severity scores [p ≥ 0.07] between reader groups.

Bottom Line: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos.The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001].Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].

View Article: PubMed Central - PubMed

Affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK simon.travis@ndm.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus