Limits...
The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ - J Crohns Colitis (2015)

Bottom Line: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos.The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001].Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].

View Article: PubMed Central - PubMed

Affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK simon.travis@ndm.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Schematic of study design. ‡Unblinded readers were provided with clinical disease activity information [symptoms and history] relating to each video, whereas blinded readers were not. †Strata: Mayo Clinic score [MCS] 0; MCS 1–2; MCS 3–5; MCS 6–7; MCS 8–9, MCS 10–11. One normal video, one most severe video, and one Mayo score 0 video were part of both pools.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4584567&req=5

Figure 1: Schematic of study design. ‡Unblinded readers were provided with clinical disease activity information [symptoms and history] relating to each video, whereas blinded readers were not. †Strata: Mayo Clinic score [MCS] 0; MCS 1–2; MCS 3–5; MCS 6–7; MCS 8–9, MCS 10–11. One normal video, one most severe video, and one Mayo score 0 video were part of both pools.

Mentions: Each reader performed 28 evaluations from the 44 videos, which included two repeats of non-control videos to evaluate intra-reader variation and the four common controls [Figure 1]. Readers were either provided with clinical information on disease activity for each video [one or two sentences on age, symptoms and history, summarised by PK/BRY/ST; unblinded group] or with no accompanying clinical information [blinded group]. Patient information was extracted from the original trials.10,11


The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Travis SP, Schnell D, Feagan BG, Abreu MT, Altman DG, Hanauer SB, Krzeski P, Lichtenstein GR, Marteau PR, Mary JY, Reinisch W, Sands BE, Schnell P, Yacyshyn BR, Colombel JF, Bernhardt CA, Sandborn WJ - J Crohns Colitis (2015)

Schematic of study design. ‡Unblinded readers were provided with clinical disease activity information [symptoms and history] relating to each video, whereas blinded readers were not. †Strata: Mayo Clinic score [MCS] 0; MCS 1–2; MCS 3–5; MCS 6–7; MCS 8–9, MCS 10–11. One normal video, one most severe video, and one Mayo score 0 video were part of both pools.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4584567&req=5

Figure 1: Schematic of study design. ‡Unblinded readers were provided with clinical disease activity information [symptoms and history] relating to each video, whereas blinded readers were not. †Strata: Mayo Clinic score [MCS] 0; MCS 1–2; MCS 3–5; MCS 6–7; MCS 8–9, MCS 10–11. One normal video, one most severe video, and one Mayo score 0 video were part of both pools.
Mentions: Each reader performed 28 evaluations from the 44 videos, which included two repeats of non-control videos to evaluate intra-reader variation and the four common controls [Figure 1]. Readers were either provided with clinical information on disease activity for each video [one or two sentences on age, symptoms and history, summarised by PK/BRY/ST; unblinded group] or with no accompanying clinical information [blinded group]. Patient information was extracted from the original trials.10,11

Bottom Line: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos.The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001].Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].

View Article: PubMed Central - PubMed

Affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK simon.travis@ndm.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus