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Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review.

Sanada K, Díez MA, Valero MS, Pérez-Yus MC, Demarzo MM, García-Toro M, García-Campayo J - Arthritis Res. Ther. (2015)

Bottom Line: However, few studies have evaluated the effect of treatment interventions on biomarker expression.Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients.Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed.

View Article: PubMed Central - PubMed

Affiliation: Aragon Health Sciences Institute (IACS), Zaragoza, Spain.

ABSTRACT

Introduction: Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacological interventions on inflammatory biomarker expression, specifically cytokines, neuropeptides and C-reactive protein (CRP), in FM patients.

Method: A literature search using PubMed, EMBASE, PsycINFO and the Cochrane library was performed from January 1990 to March 2015. Randomized controlled trials (RCTs) and non-RCTs published in English, French or Spanish were eligible.

Results: Twelve articles with a total of 536 participants were included. After exercise, multidisciplinary, or dietary interventions in FM patients, interleukin (IL) expression appeared reduced, specifically serum IL-8 and IL-6 (spontaneous, lipopolysaccharide (LPS)-induced, or serum). Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients. In contrast, evidence of changes in neuropeptide and CRP levels seemed inconsistent.

Conclusion: Despite minimal evidence, our findings indicate that exercise interventions might act as an anti-inflammatory treatment in FM patients and ameliorate inflammatory status, especially for pro-inflammatory cytokines. Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed.

No MeSH data available.


Related in: MedlinePlus

Algorithm for study selection (following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, Shamseer et al., [15])
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4584481&req=5

Fig1: Algorithm for study selection (following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, Shamseer et al., [15])

Mentions: After the initial search of 535 records, 64 were found to be duplicates (Fig. 1). We screened the titles and abstracts, and 15 articles were assessed as full text. We finally included 12 articles with a total of 536 participants.Fig. 1


Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review.

Sanada K, Díez MA, Valero MS, Pérez-Yus MC, Demarzo MM, García-Toro M, García-Campayo J - Arthritis Res. Ther. (2015)

Algorithm for study selection (following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, Shamseer et al., [15])
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4584481&req=5

Fig1: Algorithm for study selection (following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, Shamseer et al., [15])
Mentions: After the initial search of 535 records, 64 were found to be duplicates (Fig. 1). We screened the titles and abstracts, and 15 articles were assessed as full text. We finally included 12 articles with a total of 536 participants.Fig. 1

Bottom Line: However, few studies have evaluated the effect of treatment interventions on biomarker expression.Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients.Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed.

View Article: PubMed Central - PubMed

Affiliation: Aragon Health Sciences Institute (IACS), Zaragoza, Spain.

ABSTRACT

Introduction: Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacological interventions on inflammatory biomarker expression, specifically cytokines, neuropeptides and C-reactive protein (CRP), in FM patients.

Method: A literature search using PubMed, EMBASE, PsycINFO and the Cochrane library was performed from January 1990 to March 2015. Randomized controlled trials (RCTs) and non-RCTs published in English, French or Spanish were eligible.

Results: Twelve articles with a total of 536 participants were included. After exercise, multidisciplinary, or dietary interventions in FM patients, interleukin (IL) expression appeared reduced, specifically serum IL-8 and IL-6 (spontaneous, lipopolysaccharide (LPS)-induced, or serum). Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients. In contrast, evidence of changes in neuropeptide and CRP levels seemed inconsistent.

Conclusion: Despite minimal evidence, our findings indicate that exercise interventions might act as an anti-inflammatory treatment in FM patients and ameliorate inflammatory status, especially for pro-inflammatory cytokines. Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed.

No MeSH data available.


Related in: MedlinePlus