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Hydroalcoholic extract of Allium eriophyllum leaves attenuates cardiac impairment in rats with simultaneous type 2 diabetes and renal hypertension.

Janahmadi Z, Nekooeian AA, Mozafari M - Res Pharm Sci (2015 Mar-Apr)

Bottom Line: Four weeks after receiving vehicle or extract, blood pressure, fasting blood glucose, and serum superoxide dismutase and glutathione reductase levels were measured, and isolated heart studies were performed.Systolic blood pressure, fasting blood glucose, coronary effluent creatine kinase-MB, infarct size and coronary resistance of diabetic hypertensive group receiving vehicle were significantly higher than those of the sham-control group and treatment with the extract prevented the increase of these variables.Moreover, rate of rise and decrease of left ventricular pressure, left ventricular developed pressure, rate pressure product and serum levels of superoxide dismutase and glutathione reductase of diabetic hypertensive group receiving vehicle were significantly lower than those the sham-control group, and treatment with the extract prevented the decrease of these variables.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Pharmacology Research Lab, Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.

ABSTRACT
Some species of Allium family have been shown to offer cardioprotection in animal studies. This study aimed at examining possible role of oxidative stress in the cardioprotective effects of hydroalcoholic extract of Allium eriophyllum in rats with simultaneous type 2 diabetes and renal hypertension. Six groups of male Spargue-Dawley rats (8-10 rats each) including a sham-control, a diabetic group, a renal hypertensive group, three groups of animals with simultaneous diabetes and hypertension receiving vehicle, or the extract at 30 or 100 mg/kg/day were used. Four weeks after receiving vehicle or extract, blood pressure, fasting blood glucose, and serum superoxide dismutase and glutathione reductase levels were measured, and isolated heart studies were performed. Systolic blood pressure, fasting blood glucose, coronary effluent creatine kinase-MB, infarct size and coronary resistance of diabetic hypertensive group receiving vehicle were significantly higher than those of the sham-control group and treatment with the extract prevented the increase of these variables. Moreover, rate of rise and decrease of left ventricular pressure, left ventricular developed pressure, rate pressure product and serum levels of superoxide dismutase and glutathione reductase of diabetic hypertensive group receiving vehicle were significantly lower than those the sham-control group, and treatment with the extract prevented the decrease of these variables. The findings indicate that hydroalcoholic extract of A. eriophyllum leaves, possibly by an antioxidant mechanism, protected against simultaneous diabetes and hypertension-induced cardiac dysfunction.

No MeSH data available.


Related in: MedlinePlus

A; Rate of rise (+dp/dt), and B; rate of decrease (-dp/dt) of ventricular pressure of all groups (mean ± SEM, n=6-8 in each group) at preischemia (baseline), and after 30 and 60 min of reperfusion. *; Significant difference (P≤0.05) from Sham-C-Veh. #; Significant difference (P≤0.05) from DM+HTN-Veh.
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Figure 1: A; Rate of rise (+dp/dt), and B; rate of decrease (-dp/dt) of ventricular pressure of all groups (mean ± SEM, n=6-8 in each group) at preischemia (baseline), and after 30 and 60 min of reperfusion. *; Significant difference (P≤0.05) from Sham-C-Veh. #; Significant difference (P≤0.05) from DM+HTN-Veh.

Mentions: Preischemia (baseline) + dp/dt of DM-Veh and DM+HTN-Veh, but not HTN-Veh groups were significantly lower than that of Sham-C-Veh group (Fig. 1). Moreover, + dp/dt of DM+HTN-HEAEL30 and DM+HTN-HEAEL100 groups were significantly higher than that of DM+HTN-Veh. A similar pattern of difference was found at 30 and 60 min of reperfusion. There was no significant difference between + dp/dt of DM+HTN-HEAEL30 and DM+HTN-HEAEL100 groups at preischemia, or after 30 or 60 min of reperfusion (Fig. 1).


Hydroalcoholic extract of Allium eriophyllum leaves attenuates cardiac impairment in rats with simultaneous type 2 diabetes and renal hypertension.

Janahmadi Z, Nekooeian AA, Mozafari M - Res Pharm Sci (2015 Mar-Apr)

A; Rate of rise (+dp/dt), and B; rate of decrease (-dp/dt) of ventricular pressure of all groups (mean ± SEM, n=6-8 in each group) at preischemia (baseline), and after 30 and 60 min of reperfusion. *; Significant difference (P≤0.05) from Sham-C-Veh. #; Significant difference (P≤0.05) from DM+HTN-Veh.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4584451&req=5

Figure 1: A; Rate of rise (+dp/dt), and B; rate of decrease (-dp/dt) of ventricular pressure of all groups (mean ± SEM, n=6-8 in each group) at preischemia (baseline), and after 30 and 60 min of reperfusion. *; Significant difference (P≤0.05) from Sham-C-Veh. #; Significant difference (P≤0.05) from DM+HTN-Veh.
Mentions: Preischemia (baseline) + dp/dt of DM-Veh and DM+HTN-Veh, but not HTN-Veh groups were significantly lower than that of Sham-C-Veh group (Fig. 1). Moreover, + dp/dt of DM+HTN-HEAEL30 and DM+HTN-HEAEL100 groups were significantly higher than that of DM+HTN-Veh. A similar pattern of difference was found at 30 and 60 min of reperfusion. There was no significant difference between + dp/dt of DM+HTN-HEAEL30 and DM+HTN-HEAEL100 groups at preischemia, or after 30 or 60 min of reperfusion (Fig. 1).

Bottom Line: Four weeks after receiving vehicle or extract, blood pressure, fasting blood glucose, and serum superoxide dismutase and glutathione reductase levels were measured, and isolated heart studies were performed.Systolic blood pressure, fasting blood glucose, coronary effluent creatine kinase-MB, infarct size and coronary resistance of diabetic hypertensive group receiving vehicle were significantly higher than those of the sham-control group and treatment with the extract prevented the increase of these variables.Moreover, rate of rise and decrease of left ventricular pressure, left ventricular developed pressure, rate pressure product and serum levels of superoxide dismutase and glutathione reductase of diabetic hypertensive group receiving vehicle were significantly lower than those the sham-control group, and treatment with the extract prevented the decrease of these variables.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Pharmacology Research Lab, Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.

ABSTRACT
Some species of Allium family have been shown to offer cardioprotection in animal studies. This study aimed at examining possible role of oxidative stress in the cardioprotective effects of hydroalcoholic extract of Allium eriophyllum in rats with simultaneous type 2 diabetes and renal hypertension. Six groups of male Spargue-Dawley rats (8-10 rats each) including a sham-control, a diabetic group, a renal hypertensive group, three groups of animals with simultaneous diabetes and hypertension receiving vehicle, or the extract at 30 or 100 mg/kg/day were used. Four weeks after receiving vehicle or extract, blood pressure, fasting blood glucose, and serum superoxide dismutase and glutathione reductase levels were measured, and isolated heart studies were performed. Systolic blood pressure, fasting blood glucose, coronary effluent creatine kinase-MB, infarct size and coronary resistance of diabetic hypertensive group receiving vehicle were significantly higher than those of the sham-control group and treatment with the extract prevented the increase of these variables. Moreover, rate of rise and decrease of left ventricular pressure, left ventricular developed pressure, rate pressure product and serum levels of superoxide dismutase and glutathione reductase of diabetic hypertensive group receiving vehicle were significantly lower than those the sham-control group, and treatment with the extract prevented the decrease of these variables. The findings indicate that hydroalcoholic extract of A. eriophyllum leaves, possibly by an antioxidant mechanism, protected against simultaneous diabetes and hypertension-induced cardiac dysfunction.

No MeSH data available.


Related in: MedlinePlus