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Cortical network architecture for context processing in primate brain.

Chao ZC, Nagasaka Y, Fujii N - Elife (2015)

Bottom Line: We extracted five context-related network structures including a bottom-up network during encoding and, seconds later, cue-dependent retrieval of the same network with the opposite top-down connectivity.These findings show that context is represented in the cortical network as distributed communication structures with dynamic information flows.This study provides a general methodology for recording and analyzing cortical network neuronal communication during cognition.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Adaptive Intelligence, RIKEN Brain Science Institute, Wako-shi, Japan.

ABSTRACT
Context is information linked to a situation that can guide behavior. In the brain, context is encoded by sensory processing and can later be retrieved from memory. How context is communicated within the cortical network in sensory and mnemonic forms is unknown due to the lack of methods for high-resolution, brain-wide neuronal recording and analysis. Here, we report the comprehensive architecture of a cortical network for context processing. Using hemisphere-wide, high-density electrocorticography, we measured large-scale neuronal activity from monkeys observing videos of agents interacting in situations with different contexts. We extracted five context-related network structures including a bottom-up network during encoding and, seconds later, cue-dependent retrieval of the same network with the opposite top-down connectivity. These findings show that context is represented in the cortical network as distributed communication structures with dynamic information flows. This study provides a general methodology for recording and analyzing cortical network neuronal communication during cognition.

No MeSH data available.


Electrode locations in 3 subjects.In Subject 1, electrodes (green dots) were placed to cover most of the lateral surface of the right hemisphere, also the medial parts of the frontal and occipital lobes. In Subject 2, a similar layout was used, but in the left hemisphere. In Subjects 3, all electrodes were placed on the lateral surface of the left hemisphere, and no medial parts were covered. For brain map registration, the electrode locations and the brain outlines from Subjects 1 and 3 were manually registered to those from Subject 2 based on 13 markers (red circles) in the lateral hemisphere and five markers in the medial hemisphere.DOI:http://dx.doi.org/10.7554/eLife.06121.004
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fig1s1: Electrode locations in 3 subjects.In Subject 1, electrodes (green dots) were placed to cover most of the lateral surface of the right hemisphere, also the medial parts of the frontal and occipital lobes. In Subject 2, a similar layout was used, but in the left hemisphere. In Subjects 3, all electrodes were placed on the lateral surface of the left hemisphere, and no medial parts were covered. For brain map registration, the electrode locations and the brain outlines from Subjects 1 and 3 were manually registered to those from Subject 2 based on 13 markers (red circles) in the lateral hemisphere and five markers in the medial hemisphere.DOI:http://dx.doi.org/10.7554/eLife.06121.004

Mentions: Monkeys watched video clips of another monkey (video monkey, or vM) engaging with a second agent (Figure 1) while cortical activity was recorded with a 128-channel ECoG array covering nearly an entire cerebral hemisphere. Three monkeys participated, one with a right hemisphere array (Subject 1), and two in the right (Subjects 2 and 3) (Figure 1—figure supplement 1). The data are fully accessible online and can be downloaded from the website Neurotycho.org.10.7554/eLife.06121.003Figure 1.Subjects observe situational contexts with high-density electrocorticography (HD-ECoG) recording.


Cortical network architecture for context processing in primate brain.

Chao ZC, Nagasaka Y, Fujii N - Elife (2015)

Electrode locations in 3 subjects.In Subject 1, electrodes (green dots) were placed to cover most of the lateral surface of the right hemisphere, also the medial parts of the frontal and occipital lobes. In Subject 2, a similar layout was used, but in the left hemisphere. In Subjects 3, all electrodes were placed on the lateral surface of the left hemisphere, and no medial parts were covered. For brain map registration, the electrode locations and the brain outlines from Subjects 1 and 3 were manually registered to those from Subject 2 based on 13 markers (red circles) in the lateral hemisphere and five markers in the medial hemisphere.DOI:http://dx.doi.org/10.7554/eLife.06121.004
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4584448&req=5

fig1s1: Electrode locations in 3 subjects.In Subject 1, electrodes (green dots) were placed to cover most of the lateral surface of the right hemisphere, also the medial parts of the frontal and occipital lobes. In Subject 2, a similar layout was used, but in the left hemisphere. In Subjects 3, all electrodes were placed on the lateral surface of the left hemisphere, and no medial parts were covered. For brain map registration, the electrode locations and the brain outlines from Subjects 1 and 3 were manually registered to those from Subject 2 based on 13 markers (red circles) in the lateral hemisphere and five markers in the medial hemisphere.DOI:http://dx.doi.org/10.7554/eLife.06121.004
Mentions: Monkeys watched video clips of another monkey (video monkey, or vM) engaging with a second agent (Figure 1) while cortical activity was recorded with a 128-channel ECoG array covering nearly an entire cerebral hemisphere. Three monkeys participated, one with a right hemisphere array (Subject 1), and two in the right (Subjects 2 and 3) (Figure 1—figure supplement 1). The data are fully accessible online and can be downloaded from the website Neurotycho.org.10.7554/eLife.06121.003Figure 1.Subjects observe situational contexts with high-density electrocorticography (HD-ECoG) recording.

Bottom Line: We extracted five context-related network structures including a bottom-up network during encoding and, seconds later, cue-dependent retrieval of the same network with the opposite top-down connectivity.These findings show that context is represented in the cortical network as distributed communication structures with dynamic information flows.This study provides a general methodology for recording and analyzing cortical network neuronal communication during cognition.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Adaptive Intelligence, RIKEN Brain Science Institute, Wako-shi, Japan.

ABSTRACT
Context is information linked to a situation that can guide behavior. In the brain, context is encoded by sensory processing and can later be retrieved from memory. How context is communicated within the cortical network in sensory and mnemonic forms is unknown due to the lack of methods for high-resolution, brain-wide neuronal recording and analysis. Here, we report the comprehensive architecture of a cortical network for context processing. Using hemisphere-wide, high-density electrocorticography, we measured large-scale neuronal activity from monkeys observing videos of agents interacting in situations with different contexts. We extracted five context-related network structures including a bottom-up network during encoding and, seconds later, cue-dependent retrieval of the same network with the opposite top-down connectivity. These findings show that context is represented in the cortical network as distributed communication structures with dynamic information flows. This study provides a general methodology for recording and analyzing cortical network neuronal communication during cognition.

No MeSH data available.