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Brain Correlates of Self-Evaluation Deficits in Schizophrenia: A Combined Functional and Structural MRI Study.

Tan S, Zhao Y, Fan F, Zou Y, Jin Z, Zen Y, Zhu X, Yang F, Tan Y, Zhou D - PLoS ONE (2015)

Bottom Line: Control subjects showed greater activation within the dorsal medial prefrontal cortex (dMPFC) and the anterior cingulate cortex (ACC) than the patient group during the self-evaluation > semantic positivity-evaluation contrast.Patients showed greater activation mainly within the posterior cingulate gyrus (PCC) as compared to controls for the other-evaluation > semantic positivity-evaluation contrast.Furthermore, gray matter volume was reduced in the MPFC, temporal lobe, cuneus, and the dorsal lateral prefrontal cortex (DLPFC) among the patient group when compared to controls.

View Article: PubMed Central - PubMed

Affiliation: Institute of Mental Health, Peking University, Beijing, 100191, China; Center of Psychiatry Research, Beijing Huilongguan Hospital, Beijing, 100096, China.

ABSTRACT
Self-evaluation plays an important role in adaptive functioning and is a process that is typically impaired in patients with schizophrenia. Underlying neural mechanisms for this dysfunction may be associated with manifested psychosis. However, the brain substrates underlying this deficit are not well known. The present study used brain blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) and gray matter voxel-based morphometry to explore the functional and structural brain correlates of self-evaluation deficits in schizophrenia. Eighteen patients with schizophrenia and 17 healthy controls were recruited and asked to judge whether a set of personality-trait adjectives were appropriate for describing themselves, a familiar other, or whether the adjectives were of positive or negative valence. Patients had slower response times for negative trait attributions than controls did; responses to positive trait attributions were faster than those for negative traits among the patient group, while no differences were observed in the control group. Control subjects showed greater activation within the dorsal medial prefrontal cortex (dMPFC) and the anterior cingulate cortex (ACC) than the patient group during the self-evaluation > semantic positivity-evaluation contrast. Patients showed greater activation mainly within the posterior cingulate gyrus (PCC) as compared to controls for the other-evaluation > semantic positivity-evaluation contrast. Furthermore, gray matter volume was reduced in the MPFC, temporal lobe, cuneus, and the dorsal lateral prefrontal cortex (DLPFC) among the patient group when compared to controls. The present study adds to previous findings regarding self- and other-referential processing in schizophrenia, providing support for neurobiological models of self-reflection impairment.

No MeSH data available.


Related in: MedlinePlus

Brain regions showing other-semantic activation in patients with schizophrenia and the control group.One-sample tests produced the spatial patterns of brain regions showing other-semantic activation for both healthy controls (A) and patients with schizophrenia (B). Warm colors represent positive while cool colors indicate negative activation. A two-sample t-test assessed the differences between the two groups (controls versus patients, C). The above results were obtained with threshold p< 0.01, AlphaSim correction p< 0.01.
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pone.0138737.g003: Brain regions showing other-semantic activation in patients with schizophrenia and the control group.One-sample tests produced the spatial patterns of brain regions showing other-semantic activation for both healthy controls (A) and patients with schizophrenia (B). Warm colors represent positive while cool colors indicate negative activation. A two-sample t-test assessed the differences between the two groups (controls versus patients, C). The above results were obtained with threshold p< 0.01, AlphaSim correction p< 0.01.

Mentions: Further, among controls, the other-referential processing condition induced hyper-activation in the MPFC and PCC, as well as hypo-activation in the cerebellum relative to the semantic positivity-evaluation condition (Fig 3A); among patients, the other-evaluation vs. semantic positivity-evaluation contrast revealed hyper-activation in the precuneus and bilateral super frontal gyrus (Fig 3B).


Brain Correlates of Self-Evaluation Deficits in Schizophrenia: A Combined Functional and Structural MRI Study.

Tan S, Zhao Y, Fan F, Zou Y, Jin Z, Zen Y, Zhu X, Yang F, Tan Y, Zhou D - PLoS ONE (2015)

Brain regions showing other-semantic activation in patients with schizophrenia and the control group.One-sample tests produced the spatial patterns of brain regions showing other-semantic activation for both healthy controls (A) and patients with schizophrenia (B). Warm colors represent positive while cool colors indicate negative activation. A two-sample t-test assessed the differences between the two groups (controls versus patients, C). The above results were obtained with threshold p< 0.01, AlphaSim correction p< 0.01.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4583545&req=5

pone.0138737.g003: Brain regions showing other-semantic activation in patients with schizophrenia and the control group.One-sample tests produced the spatial patterns of brain regions showing other-semantic activation for both healthy controls (A) and patients with schizophrenia (B). Warm colors represent positive while cool colors indicate negative activation. A two-sample t-test assessed the differences between the two groups (controls versus patients, C). The above results were obtained with threshold p< 0.01, AlphaSim correction p< 0.01.
Mentions: Further, among controls, the other-referential processing condition induced hyper-activation in the MPFC and PCC, as well as hypo-activation in the cerebellum relative to the semantic positivity-evaluation condition (Fig 3A); among patients, the other-evaluation vs. semantic positivity-evaluation contrast revealed hyper-activation in the precuneus and bilateral super frontal gyrus (Fig 3B).

Bottom Line: Control subjects showed greater activation within the dorsal medial prefrontal cortex (dMPFC) and the anterior cingulate cortex (ACC) than the patient group during the self-evaluation > semantic positivity-evaluation contrast.Patients showed greater activation mainly within the posterior cingulate gyrus (PCC) as compared to controls for the other-evaluation > semantic positivity-evaluation contrast.Furthermore, gray matter volume was reduced in the MPFC, temporal lobe, cuneus, and the dorsal lateral prefrontal cortex (DLPFC) among the patient group when compared to controls.

View Article: PubMed Central - PubMed

Affiliation: Institute of Mental Health, Peking University, Beijing, 100191, China; Center of Psychiatry Research, Beijing Huilongguan Hospital, Beijing, 100096, China.

ABSTRACT
Self-evaluation plays an important role in adaptive functioning and is a process that is typically impaired in patients with schizophrenia. Underlying neural mechanisms for this dysfunction may be associated with manifested psychosis. However, the brain substrates underlying this deficit are not well known. The present study used brain blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) and gray matter voxel-based morphometry to explore the functional and structural brain correlates of self-evaluation deficits in schizophrenia. Eighteen patients with schizophrenia and 17 healthy controls were recruited and asked to judge whether a set of personality-trait adjectives were appropriate for describing themselves, a familiar other, or whether the adjectives were of positive or negative valence. Patients had slower response times for negative trait attributions than controls did; responses to positive trait attributions were faster than those for negative traits among the patient group, while no differences were observed in the control group. Control subjects showed greater activation within the dorsal medial prefrontal cortex (dMPFC) and the anterior cingulate cortex (ACC) than the patient group during the self-evaluation > semantic positivity-evaluation contrast. Patients showed greater activation mainly within the posterior cingulate gyrus (PCC) as compared to controls for the other-evaluation > semantic positivity-evaluation contrast. Furthermore, gray matter volume was reduced in the MPFC, temporal lobe, cuneus, and the dorsal lateral prefrontal cortex (DLPFC) among the patient group when compared to controls. The present study adds to previous findings regarding self- and other-referential processing in schizophrenia, providing support for neurobiological models of self-reflection impairment.

No MeSH data available.


Related in: MedlinePlus