Limits...
Alcohol, Smoking, Physical Activity, Protein, and Lower Urinary Tract Symptoms: Prospective Longitudinal Cohort

View Article: PubMed Central

ABSTRACT

Purpose:: To evaluate risk factors for deterioration of lower urinary tract symptoms (LUTS) in elderly men in a community-based, prospective longitudinal cohort study.

Methods:: In a suburban area in Korea, 1,514 subjects aged ≥45 years were randomly selected by systematic sampling. A total of 918 elderly subjects were enrolled in this in-depth clinical study in 2004. Of these, 547 participants were followed up for 3 years and the data was analyzed in 2014. Standard questionnaires were administered face-to-face by trained interviewers. After excluding women, 224 male participants with complete data including transrectal ultrasonography were included in the final analysis. LUTS were diagnosed using the International Prostate Symptom Score (IPSS) questionnaire. Symptom deterioration was defined as a score of ≥8 points during the 3-year follow-up period.

Results:: LUTS prevalence increased to 13.1% and the mean IPSS increased by 2.6 points during the 3-year period. After adjusting for confounders, a smoking history of ≥50 pack-years was an independent risk factor for deterioration of LUTS and storage subsymptoms compared with no history of smoking (3.1 and 5.1 odds, respectively). Physical activity had a protective effect on voiding subsymptoms. However, high protein diet and alcohol intake were not associated with LUTS deterioration.

Conclusions:: The LUTS prevalence among elderly men living in a suburban area increased to 13.1% and the IPSS increased by 2.6 points during the 3-year period. A history of heavy smoking, low physical activity, and high protein intake were associated with LUTS deterioration. However, there was no significant association between alcohol intake and LUTS deterioration.

No MeSH data available.


Related in: MedlinePlus

Deterioration of lower urinary tract symptoms (LUTS) and subsymptoms during the 3-year follow-up period in accordance with modifiable lifestyle factors. (A) Alcohol consumption: <40 mg/day vs. ≥40 mg/day; (B) smoking status: <50 pack-years (PY) vs. ≥50 PY; (C) leisure time physical activity: ≥140 kcal/day vs. <140 kcal/day; (D) protein intake: <14.6% vs. ≥14.6%; (E) vitamin C intake: ≥100 mg/day vs. <100 mg/day; (F) sodium intake: <6 g/day vs. ≥6 g/day. IPSS, International Prostate Symptom Score; QoL, quality of life. *≤0.05. † P≤0.10.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4582093&req=5

f3-inj-19-3-197: Deterioration of lower urinary tract symptoms (LUTS) and subsymptoms during the 3-year follow-up period in accordance with modifiable lifestyle factors. (A) Alcohol consumption: <40 mg/day vs. ≥40 mg/day; (B) smoking status: <50 pack-years (PY) vs. ≥50 PY; (C) leisure time physical activity: ≥140 kcal/day vs. <140 kcal/day; (D) protein intake: <14.6% vs. ≥14.6%; (E) vitamin C intake: ≥100 mg/day vs. <100 mg/day; (F) sodium intake: <6 g/day vs. ≥6 g/day. IPSS, International Prostate Symptom Score; QoL, quality of life. *≤0.05. † P≤0.10.

Mentions: There was no difference in the deterioration of LUTS between participants who consumed an average of ≥40 g of alcohol daily and those who consumed less (Fig. 3A). Heavy smokers (smoked ≥50 PY of cigarettes in a lifetime) showed a significant deterioration of storage subsymptoms (≥50 PY vs. <50 PY, 2.47±4.29 vs. 0.98±3.43, P=0.033), and there was a marginal statistical association with a greater deterioration of the total IPSS (≥50 PY vs. <50 PY, 4.60 ±9.99 vs. 2.04 ±8.49, P=0.080) (Fig. 3B). In addition, heavy smokers had significant deterioration in the nocturia subdomain of the IPSS (≥50 PY vs. <50 PY, 1.25±0.18 vs. 1.01±0.76, P=0.038). Participants with an average of <140 kcal of daily energy consumption during leisure time and physical activity experienced more severe exacerbation of voiding subsymptoms during the 3-year follow-up period (<140 kcal vs. ≥140 kcal, 2.03±6.29 vs. 0.21±6.63, P=0.046) (Fig. 3C). Participants who had a protein intake that was <14.6% of the daily calorie requirement presented with less deterioration of the total IPSS and voiding subsymptoms (<14.6% vs. ≥14.6%; IPSS: 1.88±9.58 vs. 4.83±8.48, P=0.027; voiding subscore: 0.88 ±6.13 vs. 2.78 ±6.71, P =0.044) (Fig. 3D). The deterioration of voiding subsymptoms was more severe if vitamin C intake was <100 mg/day (<100 mg vs. ≥100 mg, 2.32±6.98 vs. 0.56±5.73, P=0.047) (Fig. 3E). If the daily intake of sodium was ≥6 g, the total IPSS and storage subsymptoms worsened significantly (≥6 g vs. <6 g; IPSS: 4.10±8.85 vs. 1.44±8.65, P=0.031; storage subscore: 2.00±3.62 vs. 0.73±3.66, P=0.014) (Fig. 3F).


Alcohol, Smoking, Physical Activity, Protein, and Lower Urinary Tract Symptoms: Prospective Longitudinal Cohort
Deterioration of lower urinary tract symptoms (LUTS) and subsymptoms during the 3-year follow-up period in accordance with modifiable lifestyle factors. (A) Alcohol consumption: <40 mg/day vs. ≥40 mg/day; (B) smoking status: <50 pack-years (PY) vs. ≥50 PY; (C) leisure time physical activity: ≥140 kcal/day vs. <140 kcal/day; (D) protein intake: <14.6% vs. ≥14.6%; (E) vitamin C intake: ≥100 mg/day vs. <100 mg/day; (F) sodium intake: <6 g/day vs. ≥6 g/day. IPSS, International Prostate Symptom Score; QoL, quality of life. *≤0.05. † P≤0.10.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4582093&req=5

f3-inj-19-3-197: Deterioration of lower urinary tract symptoms (LUTS) and subsymptoms during the 3-year follow-up period in accordance with modifiable lifestyle factors. (A) Alcohol consumption: <40 mg/day vs. ≥40 mg/day; (B) smoking status: <50 pack-years (PY) vs. ≥50 PY; (C) leisure time physical activity: ≥140 kcal/day vs. <140 kcal/day; (D) protein intake: <14.6% vs. ≥14.6%; (E) vitamin C intake: ≥100 mg/day vs. <100 mg/day; (F) sodium intake: <6 g/day vs. ≥6 g/day. IPSS, International Prostate Symptom Score; QoL, quality of life. *≤0.05. † P≤0.10.
Mentions: There was no difference in the deterioration of LUTS between participants who consumed an average of ≥40 g of alcohol daily and those who consumed less (Fig. 3A). Heavy smokers (smoked ≥50 PY of cigarettes in a lifetime) showed a significant deterioration of storage subsymptoms (≥50 PY vs. <50 PY, 2.47±4.29 vs. 0.98±3.43, P=0.033), and there was a marginal statistical association with a greater deterioration of the total IPSS (≥50 PY vs. <50 PY, 4.60 ±9.99 vs. 2.04 ±8.49, P=0.080) (Fig. 3B). In addition, heavy smokers had significant deterioration in the nocturia subdomain of the IPSS (≥50 PY vs. <50 PY, 1.25±0.18 vs. 1.01±0.76, P=0.038). Participants with an average of <140 kcal of daily energy consumption during leisure time and physical activity experienced more severe exacerbation of voiding subsymptoms during the 3-year follow-up period (<140 kcal vs. ≥140 kcal, 2.03±6.29 vs. 0.21±6.63, P=0.046) (Fig. 3C). Participants who had a protein intake that was <14.6% of the daily calorie requirement presented with less deterioration of the total IPSS and voiding subsymptoms (<14.6% vs. ≥14.6%; IPSS: 1.88±9.58 vs. 4.83±8.48, P=0.027; voiding subscore: 0.88 ±6.13 vs. 2.78 ±6.71, P =0.044) (Fig. 3D). The deterioration of voiding subsymptoms was more severe if vitamin C intake was <100 mg/day (<100 mg vs. ≥100 mg, 2.32±6.98 vs. 0.56±5.73, P=0.047) (Fig. 3E). If the daily intake of sodium was ≥6 g, the total IPSS and storage subsymptoms worsened significantly (≥6 g vs. <6 g; IPSS: 4.10±8.85 vs. 1.44±8.65, P=0.031; storage subscore: 2.00±3.62 vs. 0.73±3.66, P=0.014) (Fig. 3F).

View Article: PubMed Central

ABSTRACT

Purpose:: To evaluate risk factors for deterioration of lower urinary tract symptoms (LUTS) in elderly men in a community-based, prospective longitudinal cohort study.

Methods:: In a suburban area in Korea, 1,514 subjects aged &ge;45 years were randomly selected by systematic sampling. A total of 918 elderly subjects were enrolled in this in-depth clinical study in 2004. Of these, 547 participants were followed up for 3 years and the data was analyzed in 2014. Standard questionnaires were administered face-to-face by trained interviewers. After excluding women, 224 male participants with complete data including transrectal ultrasonography were included in the final analysis. LUTS were diagnosed using the International Prostate Symptom Score (IPSS) questionnaire. Symptom deterioration was defined as a score of &ge;8 points during the 3-year follow-up period.

Results:: LUTS prevalence increased to 13.1% and the mean IPSS increased by 2.6 points during the 3-year period. After adjusting for confounders, a smoking history of &ge;50 pack-years was an independent risk factor for deterioration of LUTS and storage subsymptoms compared with no history of smoking (3.1 and 5.1 odds, respectively). Physical activity had a protective effect on voiding subsymptoms. However, high protein diet and alcohol intake were not associated with LUTS deterioration.

Conclusions:: The LUTS prevalence among elderly men living in a suburban area increased to 13.1% and the IPSS increased by 2.6 points during the 3-year period. A history of heavy smoking, low physical activity, and high protein intake were associated with LUTS deterioration. However, there was no significant association between alcohol intake and LUTS deterioration.

No MeSH data available.


Related in: MedlinePlus