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Atypical processing of voice sounds in infants at risk for autism spectrum disorder.

Blasi A, Lloyd-Fox S, Sethna V, Brammer MJ, Mercure E, Murray L, Williams SC, Simmons A, Murphy DG, Johnson MH - Cortex (2015)

Bottom Line: Whereas LR infants showed early specialisation for human voice processing in right temporal and medial frontal regions, the HR infants did not.These results suggest that at least some infants at high-risk for ASD have atypical neural responses to human voice with and without emotional valence.Further exploration of the relationship between behaviour during social interaction and voice processing may help better understand the mechanisms that lead to different outcomes in at risk populations.

View Article: PubMed Central - PubMed

Affiliation: Birkbeck, University of London, Centre for Brain and Cognitive Development, UK; King's College London, Institute of Psychiatry, Psychology & Neuroscience, Sackler Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Science, UK. Electronic address: a.blasiribera@bbk.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Neutral voice versus sad voice group differences. Representation on an age-appropriate infant template (Sanchez et al., 2012) of the between group differences in neutral voice versus sad voice contrast. Significant clusters with responses to sad voices stronger than to neutral voices are represented in cyan; significant clusters where response to neutral voice > sad voice are represented in blue. (a) Three-dimensional rendering of the group differences. (b) Results on slices of the same template. See also Table 2.
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fig2: Neutral voice versus sad voice group differences. Representation on an age-appropriate infant template (Sanchez et al., 2012) of the between group differences in neutral voice versus sad voice contrast. Significant clusters with responses to sad voices stronger than to neutral voices are represented in cyan; significant clusters where response to neutral voice > sad voice are represented in blue. (a) Three-dimensional rendering of the group differences. (b) Results on slices of the same template. See also Table 2.

Mentions: In the analyses of sensitivity to sad affect in voice (sad voice > neutral voice) the low-risk infants showed stronger activation than high-risk infants to sad vocal sounds in the right fusiform gyrus and left hippocampus (Table 1 and Fig. 2). High-risk infants did not activate significantly more than the low-risk in any brain region. With reference to the neutral voice greater than sad voice contrast, group differences (mostly low-risk infants showing stronger activation than high-risk infants) were found bilaterally in the caudate, and the right superior frontal gyrus (Table 1 and Fig. 2).


Atypical processing of voice sounds in infants at risk for autism spectrum disorder.

Blasi A, Lloyd-Fox S, Sethna V, Brammer MJ, Mercure E, Murray L, Williams SC, Simmons A, Murphy DG, Johnson MH - Cortex (2015)

Neutral voice versus sad voice group differences. Representation on an age-appropriate infant template (Sanchez et al., 2012) of the between group differences in neutral voice versus sad voice contrast. Significant clusters with responses to sad voices stronger than to neutral voices are represented in cyan; significant clusters where response to neutral voice > sad voice are represented in blue. (a) Three-dimensional rendering of the group differences. (b) Results on slices of the same template. See also Table 2.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4582069&req=5

fig2: Neutral voice versus sad voice group differences. Representation on an age-appropriate infant template (Sanchez et al., 2012) of the between group differences in neutral voice versus sad voice contrast. Significant clusters with responses to sad voices stronger than to neutral voices are represented in cyan; significant clusters where response to neutral voice > sad voice are represented in blue. (a) Three-dimensional rendering of the group differences. (b) Results on slices of the same template. See also Table 2.
Mentions: In the analyses of sensitivity to sad affect in voice (sad voice > neutral voice) the low-risk infants showed stronger activation than high-risk infants to sad vocal sounds in the right fusiform gyrus and left hippocampus (Table 1 and Fig. 2). High-risk infants did not activate significantly more than the low-risk in any brain region. With reference to the neutral voice greater than sad voice contrast, group differences (mostly low-risk infants showing stronger activation than high-risk infants) were found bilaterally in the caudate, and the right superior frontal gyrus (Table 1 and Fig. 2).

Bottom Line: Whereas LR infants showed early specialisation for human voice processing in right temporal and medial frontal regions, the HR infants did not.These results suggest that at least some infants at high-risk for ASD have atypical neural responses to human voice with and without emotional valence.Further exploration of the relationship between behaviour during social interaction and voice processing may help better understand the mechanisms that lead to different outcomes in at risk populations.

View Article: PubMed Central - PubMed

Affiliation: Birkbeck, University of London, Centre for Brain and Cognitive Development, UK; King's College London, Institute of Psychiatry, Psychology & Neuroscience, Sackler Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Science, UK. Electronic address: a.blasiribera@bbk.ac.uk.

No MeSH data available.


Related in: MedlinePlus