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Atypical processing of voice sounds in infants at risk for autism spectrum disorder.

Blasi A, Lloyd-Fox S, Sethna V, Brammer MJ, Mercure E, Murray L, Williams SC, Simmons A, Murphy DG, Johnson MH - Cortex (2015)

Bottom Line: Whereas LR infants showed early specialisation for human voice processing in right temporal and medial frontal regions, the HR infants did not.These results suggest that at least some infants at high-risk for ASD have atypical neural responses to human voice with and without emotional valence.Further exploration of the relationship between behaviour during social interaction and voice processing may help better understand the mechanisms that lead to different outcomes in at risk populations.

View Article: PubMed Central - PubMed

Affiliation: Birkbeck, University of London, Centre for Brain and Cognitive Development, UK; King's College London, Institute of Psychiatry, Psychology & Neuroscience, Sackler Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Science, UK. Electronic address: a.blasiribera@bbk.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Neutral voice greater than non voice contrast. Representation on an age-appropriate infant template (Sanchez, Richards, & Almli, 2012) of the neutral voice greater than non voice condition contrast. (a) Low risk group, (b) high risk group, (c, d) group differences in the condition contrast; (L) left hemisphere, and (R) right hemisphere. See also Supplementary Tables 2 and 3
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fig1: Neutral voice greater than non voice contrast. Representation on an age-appropriate infant template (Sanchez, Richards, & Almli, 2012) of the neutral voice greater than non voice condition contrast. (a) Low risk group, (b) high risk group, (c, d) group differences in the condition contrast; (L) left hemisphere, and (R) right hemisphere. See also Supplementary Tables 2 and 3

Mentions: Infants in the low-risk group showed significantly stronger responses to the neutral voice condition as compared to the non voice condition (voice selectivity), bilaterally in the superior and middle temporal gyrus, in the superior and middle frontal gyrus, and also in the right cingulate gyrus. By contrast, infants in the high-risk group preferentially activated to neutral voice over the non voice condition, only in the right inferior parietal lobule and (similarly to the low-risk group) in a region of the right cingulate gyrus (Fig. 1a and Supplementary Table 2).


Atypical processing of voice sounds in infants at risk for autism spectrum disorder.

Blasi A, Lloyd-Fox S, Sethna V, Brammer MJ, Mercure E, Murray L, Williams SC, Simmons A, Murphy DG, Johnson MH - Cortex (2015)

Neutral voice greater than non voice contrast. Representation on an age-appropriate infant template (Sanchez, Richards, & Almli, 2012) of the neutral voice greater than non voice condition contrast. (a) Low risk group, (b) high risk group, (c, d) group differences in the condition contrast; (L) left hemisphere, and (R) right hemisphere. See also Supplementary Tables 2 and 3
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4582069&req=5

fig1: Neutral voice greater than non voice contrast. Representation on an age-appropriate infant template (Sanchez, Richards, & Almli, 2012) of the neutral voice greater than non voice condition contrast. (a) Low risk group, (b) high risk group, (c, d) group differences in the condition contrast; (L) left hemisphere, and (R) right hemisphere. See also Supplementary Tables 2 and 3
Mentions: Infants in the low-risk group showed significantly stronger responses to the neutral voice condition as compared to the non voice condition (voice selectivity), bilaterally in the superior and middle temporal gyrus, in the superior and middle frontal gyrus, and also in the right cingulate gyrus. By contrast, infants in the high-risk group preferentially activated to neutral voice over the non voice condition, only in the right inferior parietal lobule and (similarly to the low-risk group) in a region of the right cingulate gyrus (Fig. 1a and Supplementary Table 2).

Bottom Line: Whereas LR infants showed early specialisation for human voice processing in right temporal and medial frontal regions, the HR infants did not.These results suggest that at least some infants at high-risk for ASD have atypical neural responses to human voice with and without emotional valence.Further exploration of the relationship between behaviour during social interaction and voice processing may help better understand the mechanisms that lead to different outcomes in at risk populations.

View Article: PubMed Central - PubMed

Affiliation: Birkbeck, University of London, Centre for Brain and Cognitive Development, UK; King's College London, Institute of Psychiatry, Psychology & Neuroscience, Sackler Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Science, UK. Electronic address: a.blasiribera@bbk.ac.uk.

No MeSH data available.


Related in: MedlinePlus