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Amino acids in sandal (Santalum album L) with special reference to cis-4-hydroxy-l-proline and sym. homospermidine.

Kuttan R, Panikkar B, Binitha PP - Springerplus (2015)

Bottom Line: Sandal also contains sym. homospermidine which is not present in any other plants till today.Moreover sandal leaves contain γ-glutamyl derivative of the lachrymatory precursor of onion, γ-glutamyl-S-propenyl cysteine superoxide.This review summarizes the studies on the amino acids in sandal.

View Article: PubMed Central - PubMed

Affiliation: Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680555 India.

ABSTRACT
Sandal (Santalum album L) contains several interesting amino acids and amines which are not seen in other plants. This includes cis-4-hydroxy-l-proline in free form in leaves, flowers and seeds while trans-4-hydroxy-l-proline in bound form. Traces of 3, 4 dehydroproline is also detected in sandal leaves. Biosynthesis of cis-4-hydroxy proline indicates that hydroxylation taken place at proline present in peptidyl form especially bound to glutamic acid and aspartic acid. Pyrrolizidine-2-carboxylic acid an interesting isatin positive heterocyclic compound is also present in sandal leaves. Sandal also contains sym. homospermidine which is not present in any other plants till today. Biosynthesis of sym. homospermidine goes by a unique pathway of putrescine oxidation, Schiff base formation, condensation and reduction. Moreover sandal leaves contain γ-glutamyl derivative of the lachrymatory precursor of onion, γ-glutamyl-S-propenyl cysteine superoxide. This review summarizes the studies on the amino acids in sandal.

No MeSH data available.


Related in: MedlinePlus

Biosynthesis of cis-4-hydroxyproline
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Fig4: Biosynthesis of cis-4-hydroxyproline

Mentions: These evidences indicate that the cis-hydroxy proline synthesis in the sandal leaves may be taking place in the peptide chain (Fig. 4). Hydroxylation reaction may be taking place on peptide rich in acidic amino acids such as glutamic acid and aspartic acid. It is tempting to speculate that γ-glutamyl proline or β-aspartyl proline are the possible substrates for the hydroxylase. The molecular weight of the substrate is not known at present. γ-Glutamyl compounds are reported in sandal as well as in other plants as nitrogen storing material. However their role in producing hydroxy proline needs to be further studied.Fig. 4


Amino acids in sandal (Santalum album L) with special reference to cis-4-hydroxy-l-proline and sym. homospermidine.

Kuttan R, Panikkar B, Binitha PP - Springerplus (2015)

Biosynthesis of cis-4-hydroxyproline
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4582034&req=5

Fig4: Biosynthesis of cis-4-hydroxyproline
Mentions: These evidences indicate that the cis-hydroxy proline synthesis in the sandal leaves may be taking place in the peptide chain (Fig. 4). Hydroxylation reaction may be taking place on peptide rich in acidic amino acids such as glutamic acid and aspartic acid. It is tempting to speculate that γ-glutamyl proline or β-aspartyl proline are the possible substrates for the hydroxylase. The molecular weight of the substrate is not known at present. γ-Glutamyl compounds are reported in sandal as well as in other plants as nitrogen storing material. However their role in producing hydroxy proline needs to be further studied.Fig. 4

Bottom Line: Sandal also contains sym. homospermidine which is not present in any other plants till today.Moreover sandal leaves contain γ-glutamyl derivative of the lachrymatory precursor of onion, γ-glutamyl-S-propenyl cysteine superoxide.This review summarizes the studies on the amino acids in sandal.

View Article: PubMed Central - PubMed

Affiliation: Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680555 India.

ABSTRACT
Sandal (Santalum album L) contains several interesting amino acids and amines which are not seen in other plants. This includes cis-4-hydroxy-l-proline in free form in leaves, flowers and seeds while trans-4-hydroxy-l-proline in bound form. Traces of 3, 4 dehydroproline is also detected in sandal leaves. Biosynthesis of cis-4-hydroxy proline indicates that hydroxylation taken place at proline present in peptidyl form especially bound to glutamic acid and aspartic acid. Pyrrolizidine-2-carboxylic acid an interesting isatin positive heterocyclic compound is also present in sandal leaves. Sandal also contains sym. homospermidine which is not present in any other plants till today. Biosynthesis of sym. homospermidine goes by a unique pathway of putrescine oxidation, Schiff base formation, condensation and reduction. Moreover sandal leaves contain γ-glutamyl derivative of the lachrymatory precursor of onion, γ-glutamyl-S-propenyl cysteine superoxide. This review summarizes the studies on the amino acids in sandal.

No MeSH data available.


Related in: MedlinePlus