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Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.

Kandi V, Vadakedath S - Cureus (2015)

Bottom Line: These regions are more susceptible to DNA methylations.Nutritional supplementation of folic acid and methionine in utero and in adults decreased epigenetic modifications due to its role in DNA metabolism (one carbon metabolism). Thus, in utero and adult supplementation of folic acid and methionine may reduce DNA methylation.This review attempts to highlight the process of DNA methylation, its effect on various diseases, and the probable protective role of nutrition.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Microbiology, Prathima Institute of Medical Sciences.

ABSTRACT
DNA methylation, a process of adding a methyl group to DNA done by a DNA methyltransferase is a heritable (epigenetic) alteration leading to cancer, atherosclerosis, nervous disorders (Imprinting disorders), and cardiovascular diseases. The role of nutrition in DNA methylation is revealed by identification of methyl variable positions (MVP) on DNA. These regions are more susceptible to DNA methylations. Nutritional supplementation of folic acid and methionine in utero and in adults decreased epigenetic modifications due to its role in DNA metabolism (one carbon metabolism). Thus, in utero and adult supplementation of folic acid and methionine may reduce DNA methylation. This review attempts to highlight the process of DNA methylation, its effect on various diseases, and the probable protective role of nutrition.

No MeSH data available.


Related in: MedlinePlus

Flow chart showing various causes of hyper/hypo methylationof DNA leading to Atherosclerotic lesions
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FIG2: Flow chart showing various causes of hyper/hypo methylationof DNA leading to Atherosclerotic lesions

Mentions: DNA methylation polymorphism forms an important biomarker for atherosclerosis. Monocytes and lymphocytes are the sites for DNA methylation polymorphism [23-25] (Figure 2).


Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.

Kandi V, Vadakedath S - Cureus (2015)

Flow chart showing various causes of hyper/hypo methylationof DNA leading to Atherosclerotic lesions
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4582005&req=5

FIG2: Flow chart showing various causes of hyper/hypo methylationof DNA leading to Atherosclerotic lesions
Mentions: DNA methylation polymorphism forms an important biomarker for atherosclerosis. Monocytes and lymphocytes are the sites for DNA methylation polymorphism [23-25] (Figure 2).

Bottom Line: These regions are more susceptible to DNA methylations.Nutritional supplementation of folic acid and methionine in utero and in adults decreased epigenetic modifications due to its role in DNA metabolism (one carbon metabolism). Thus, in utero and adult supplementation of folic acid and methionine may reduce DNA methylation.This review attempts to highlight the process of DNA methylation, its effect on various diseases, and the probable protective role of nutrition.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Microbiology, Prathima Institute of Medical Sciences.

ABSTRACT
DNA methylation, a process of adding a methyl group to DNA done by a DNA methyltransferase is a heritable (epigenetic) alteration leading to cancer, atherosclerosis, nervous disorders (Imprinting disorders), and cardiovascular diseases. The role of nutrition in DNA methylation is revealed by identification of methyl variable positions (MVP) on DNA. These regions are more susceptible to DNA methylations. Nutritional supplementation of folic acid and methionine in utero and in adults decreased epigenetic modifications due to its role in DNA metabolism (one carbon metabolism). Thus, in utero and adult supplementation of folic acid and methionine may reduce DNA methylation. This review attempts to highlight the process of DNA methylation, its effect on various diseases, and the probable protective role of nutrition.

No MeSH data available.


Related in: MedlinePlus