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Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants.

Maruyama H, Yonemoto N, Kono Y, Kusuda S, Fujimura M, Neonatal Research Network of Jap - PLoS ONE (2015)

Bottom Line: With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60-3.62) and 1.81 (95%CI, 1.18-2.75), respectively, relative to the reference WGV score of 10.WGV scores ≥8 did not predict death or NDI.WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Kochi Health Sciences Center, Kochi, Kochi, Japan.

ABSTRACT

Introduction: This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs).

Methods: Subjects were infants who weighed 501-1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003-2007). Patel's exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI).

Results: In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4-11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60-3.62) and 1.81 (95%CI, 1.18-2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI.

Conclusions: WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs.

No MeSH data available.


Related in: MedlinePlus

Relationship between weight growth velocity (WGV) scores 6–14 and their adjusted odds ratios (AORs) with 95% confidence intervals (CIs).WGV scores 6 and 7 predicted death or NDI at 3 years of age.
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pone.0139014.g003: Relationship between weight growth velocity (WGV) scores 6–14 and their adjusted odds ratios (AORs) with 95% confidence intervals (CIs).WGV scores 6 and 7 predicted death or NDI at 3 years of age.

Mentions: With the categorical approach, only WGV scores 6 (AOR, 2.41; 95%CI, 1.60–3.62) and 7 (AOR, 1.81; 95%CI, 1.18–2.75) predicted death or NDI at 3 years of age (Table 2 and Fig 3). The AUC was 0.67. Subgroup analyses for the primary outcome were similar to the main analysis, with the exception of GA ≥28 weeks. AOR of the infants in the group GA ≥28 weeks was not significantly related to the WGV score, except that AOR in the WGV score 6 was 3.57 (95%CI, 1.32–9.69). In the sensitivity analysis after excluding 495 infants with extremely long stays in the NICU, AORs of WGV scores 6 and 7 were 0.58 (95%CI, 0.17–1.54) and 1.87 (95%CI, 0.93–3.58), respectively.


Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants.

Maruyama H, Yonemoto N, Kono Y, Kusuda S, Fujimura M, Neonatal Research Network of Jap - PLoS ONE (2015)

Relationship between weight growth velocity (WGV) scores 6–14 and their adjusted odds ratios (AORs) with 95% confidence intervals (CIs).WGV scores 6 and 7 predicted death or NDI at 3 years of age.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581837&req=5

pone.0139014.g003: Relationship between weight growth velocity (WGV) scores 6–14 and their adjusted odds ratios (AORs) with 95% confidence intervals (CIs).WGV scores 6 and 7 predicted death or NDI at 3 years of age.
Mentions: With the categorical approach, only WGV scores 6 (AOR, 2.41; 95%CI, 1.60–3.62) and 7 (AOR, 1.81; 95%CI, 1.18–2.75) predicted death or NDI at 3 years of age (Table 2 and Fig 3). The AUC was 0.67. Subgroup analyses for the primary outcome were similar to the main analysis, with the exception of GA ≥28 weeks. AOR of the infants in the group GA ≥28 weeks was not significantly related to the WGV score, except that AOR in the WGV score 6 was 3.57 (95%CI, 1.32–9.69). In the sensitivity analysis after excluding 495 infants with extremely long stays in the NICU, AORs of WGV scores 6 and 7 were 0.58 (95%CI, 0.17–1.54) and 1.87 (95%CI, 0.93–3.58), respectively.

Bottom Line: With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60-3.62) and 1.81 (95%CI, 1.18-2.75), respectively, relative to the reference WGV score of 10.WGV scores ≥8 did not predict death or NDI.WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Kochi Health Sciences Center, Kochi, Kochi, Japan.

ABSTRACT

Introduction: This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs).

Methods: Subjects were infants who weighed 501-1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003-2007). Patel's exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI).

Results: In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4-11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60-3.62) and 1.81 (95%CI, 1.18-2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI.

Conclusions: WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs.

No MeSH data available.


Related in: MedlinePlus