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Anatomical and functional brain abnormalities in unmedicated major depressive disorder.

Yang X, Ma X, Li M, Liu Y, Zhang J, Huang B, Zhao L, Deng W, Li T, Ma X - Neuropsychiatr Dis Treat (2015)

Bottom Line: Compared to healthy controls, patients with MDD showed significant GMV increase in the left posterior cingulate gyrus and GMV decrease in the left lingual gyrus (P<0.001, uncorrected).In ReHo analysis, values were significantly increased in the left precuneus and decreased in the left putamen (P<0.001, uncorrected) in patients with MDD compared to healthy controls.These changes were not significantly correlated with symptom severity.

View Article: PubMed Central - PubMed

Affiliation: Psychiatric Laboratory and Department of Psychiatry, Sichuan University, Chengdu, People's Republic of China ; National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

ABSTRACT

Background: Using magnetic resonance imaging (MRI) and resting-state functional magnetic resonance imaging (rsfMRI) to explore the mechanism of brain structure and function in unmedicated patients with major depressive disorder (MDD).

Patients and methods: Fifty patients with MDD and 50 matched healthy control participants free of psychotropic medication underwent high-resolution structural and rsfMRI scanning. Optimized diffeomorphic anatomical registration through exponentiated lie algebra and the Data Processing Assistant for rsfMRI were used to find potential differences in gray-matter volume (GMV) and regional homogeneity (ReHo) between the two groups. A Pearson correlation model was used to analyze associations of morphometric and functional changes with clinical symptoms.

Results: Compared to healthy controls, patients with MDD showed significant GMV increase in the left posterior cingulate gyrus and GMV decrease in the left lingual gyrus (P<0.001, uncorrected). In ReHo analysis, values were significantly increased in the left precuneus and decreased in the left putamen (P<0.001, uncorrected) in patients with MDD compared to healthy controls. There was no overlap between anatomical and functional changes. Linear correlation suggested no significant correlation between mean GMV values within regions with anatomical abnormality and ReHo values in regions with functional abnormality in the patient group. These changes were not significantly correlated with symptom severity.

Conclusion: Our study suggests a dissociation pattern of brain regions with anatomical and functional alterations in unmedicated patients with MDD, especially with regard to GMV and ReHo.

No MeSH data available.


Related in: MedlinePlus

Regional homogeneity abnormalities during resting-state functional imaging between unmedicated major depressive disorder patients and healthy controls.Notes: Significant group differences were identified by t-test (P<0.001, corrected for multiple comparisons with the AlphaSim program). The color bar represents the t-values of two sample t-test. Regions showing increased regional homogeneity in patients were located in (A) the left precuneus; regions with decreased regional homogeneity in patients were located in (B) the left putamen.Abbreviations: L, left; R, right.
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f2-ndt-11-2415: Regional homogeneity abnormalities during resting-state functional imaging between unmedicated major depressive disorder patients and healthy controls.Notes: Significant group differences were identified by t-test (P<0.001, corrected for multiple comparisons with the AlphaSim program). The color bar represents the t-values of two sample t-test. Regions showing increased regional homogeneity in patients were located in (A) the left precuneus; regions with decreased regional homogeneity in patients were located in (B) the left putamen.Abbreviations: L, left; R, right.

Mentions: Relative to healthy controls, patients with MDD showed significantly increased GMV in the left posterior cingulate gyrus (PCG; Montreal Neurological Institute [MNI]: x=−3, y=−48, z=8, voxels =208; P<0.001, uncorrected) and significantly decreased GMV in the left lingual gyrus (LG; MNI: x=−25, y=−64, z=−4, voxels =251; P<0.001, uncorrected) (Figure 1). With regard to the ReHo comparison, patients showed significantly increased ReHo values in the left precuneus (MNI: x=−12, y=−63, z=60, voxels =44; P<0.001, uncorrected) and decreased ReHo values in the left putamen (MNI: x=−27, y=−6, z=−3, voxels =28; P<0.001, uncorrected) (Figure 2, Table 2).


Anatomical and functional brain abnormalities in unmedicated major depressive disorder.

Yang X, Ma X, Li M, Liu Y, Zhang J, Huang B, Zhao L, Deng W, Li T, Ma X - Neuropsychiatr Dis Treat (2015)

Regional homogeneity abnormalities during resting-state functional imaging between unmedicated major depressive disorder patients and healthy controls.Notes: Significant group differences were identified by t-test (P<0.001, corrected for multiple comparisons with the AlphaSim program). The color bar represents the t-values of two sample t-test. Regions showing increased regional homogeneity in patients were located in (A) the left precuneus; regions with decreased regional homogeneity in patients were located in (B) the left putamen.Abbreviations: L, left; R, right.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581780&req=5

f2-ndt-11-2415: Regional homogeneity abnormalities during resting-state functional imaging between unmedicated major depressive disorder patients and healthy controls.Notes: Significant group differences were identified by t-test (P<0.001, corrected for multiple comparisons with the AlphaSim program). The color bar represents the t-values of two sample t-test. Regions showing increased regional homogeneity in patients were located in (A) the left precuneus; regions with decreased regional homogeneity in patients were located in (B) the left putamen.Abbreviations: L, left; R, right.
Mentions: Relative to healthy controls, patients with MDD showed significantly increased GMV in the left posterior cingulate gyrus (PCG; Montreal Neurological Institute [MNI]: x=−3, y=−48, z=8, voxels =208; P<0.001, uncorrected) and significantly decreased GMV in the left lingual gyrus (LG; MNI: x=−25, y=−64, z=−4, voxels =251; P<0.001, uncorrected) (Figure 1). With regard to the ReHo comparison, patients showed significantly increased ReHo values in the left precuneus (MNI: x=−12, y=−63, z=60, voxels =44; P<0.001, uncorrected) and decreased ReHo values in the left putamen (MNI: x=−27, y=−6, z=−3, voxels =28; P<0.001, uncorrected) (Figure 2, Table 2).

Bottom Line: Compared to healthy controls, patients with MDD showed significant GMV increase in the left posterior cingulate gyrus and GMV decrease in the left lingual gyrus (P<0.001, uncorrected).In ReHo analysis, values were significantly increased in the left precuneus and decreased in the left putamen (P<0.001, uncorrected) in patients with MDD compared to healthy controls.These changes were not significantly correlated with symptom severity.

View Article: PubMed Central - PubMed

Affiliation: Psychiatric Laboratory and Department of Psychiatry, Sichuan University, Chengdu, People's Republic of China ; National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

ABSTRACT

Background: Using magnetic resonance imaging (MRI) and resting-state functional magnetic resonance imaging (rsfMRI) to explore the mechanism of brain structure and function in unmedicated patients with major depressive disorder (MDD).

Patients and methods: Fifty patients with MDD and 50 matched healthy control participants free of psychotropic medication underwent high-resolution structural and rsfMRI scanning. Optimized diffeomorphic anatomical registration through exponentiated lie algebra and the Data Processing Assistant for rsfMRI were used to find potential differences in gray-matter volume (GMV) and regional homogeneity (ReHo) between the two groups. A Pearson correlation model was used to analyze associations of morphometric and functional changes with clinical symptoms.

Results: Compared to healthy controls, patients with MDD showed significant GMV increase in the left posterior cingulate gyrus and GMV decrease in the left lingual gyrus (P<0.001, uncorrected). In ReHo analysis, values were significantly increased in the left precuneus and decreased in the left putamen (P<0.001, uncorrected) in patients with MDD compared to healthy controls. There was no overlap between anatomical and functional changes. Linear correlation suggested no significant correlation between mean GMV values within regions with anatomical abnormality and ReHo values in regions with functional abnormality in the patient group. These changes were not significantly correlated with symptom severity.

Conclusion: Our study suggests a dissociation pattern of brain regions with anatomical and functional alterations in unmedicated patients with MDD, especially with regard to GMV and ReHo.

No MeSH data available.


Related in: MedlinePlus