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Imported Genotype 2B Rubella Virus Caused the 2012 Outbreak in Anqing City, China.

Zhu Z, Pan G, Zhou S, Dai J, Chen X, Tang J, Chen S, Zheng Y, Song J, Xu W - PLoS ONE (2015)

Bottom Line: However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation.After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination.In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

View Article: PubMed Central - PubMed

Affiliation: WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

ABSTRACT
A rubella outbreak occurred in Anqing city of Anhui province, China, from February to July of 2012, and a total of 241 clinically diagnosed or lab-confirmed patients were reported. The highest number of rubella cases during this outbreak was recorded in teenagers between 10 and 19 years of age who had not previously received the rubella vaccine. Genotyping results indicated that the genotype 2B rubella virus (RV) was responsible for the outbreak. However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation. After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination. Strengthening rubella surveillance, including the integration of epidemiologic information and laboratory data, is a vital strategy for rubella control and elimination. In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

No MeSH data available.


Related in: MedlinePlus

Phylogenetic analysis of the sequences of 27 Anqing RVs (shown in red), 10 RVs collected in 5 cities of Anhui province between 2012 and 2014 (shown in blue), and 11 2B RVs from other provinces of China during 2011–2014 based on the WHO standard 739-nt window.Genotype 1E and 2B WHO reference strains are indicated by blue triangles.
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pone.0139173.g006: Phylogenetic analysis of the sequences of 27 Anqing RVs (shown in red), 10 RVs collected in 5 cities of Anhui province between 2012 and 2014 (shown in blue), and 11 2B RVs from other provinces of China during 2011–2014 based on the WHO standard 739-nt window.Genotype 1E and 2B WHO reference strains are indicated by blue triangles.

Mentions: To further understand the transmission of Anqing RVs in Anhui province since 2012, a phylogenetic analysis of Anqing RV sequences, 10 RVs collected in 5 cities of Anhui province between 2012 and 2014 [Wuhu (2012:1; 2013:4), Huainan (2012:1; 2013:1), Bengbu (2014:1), Tongling (2014:1), and Hefei (2014:1)], and 11 2B RVs from other provinces of China collected during 2011–2014 (Fig 6) showed that RVs in Anhui province in 2013 and 2014 could be grouped into genotype 1E (5 RVs from 2 cities in 2013) and 2B (3 RVs from 3 cities in 2014), respectively. Genotype 2B RVs in 2014 clustered separately from all Anqing RVs, and were closely related to 2B RVs from Wuhu and Huainan city in 2012 and from provinces of China other than Anhui, the currently predominant virus circulating in China (unpublished data). These data indicated that after importation, the transmission of Anqing RVs was likely interrupted owing to effective rubella vaccination.


Imported Genotype 2B Rubella Virus Caused the 2012 Outbreak in Anqing City, China.

Zhu Z, Pan G, Zhou S, Dai J, Chen X, Tang J, Chen S, Zheng Y, Song J, Xu W - PLoS ONE (2015)

Phylogenetic analysis of the sequences of 27 Anqing RVs (shown in red), 10 RVs collected in 5 cities of Anhui province between 2012 and 2014 (shown in blue), and 11 2B RVs from other provinces of China during 2011–2014 based on the WHO standard 739-nt window.Genotype 1E and 2B WHO reference strains are indicated by blue triangles.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581689&req=5

pone.0139173.g006: Phylogenetic analysis of the sequences of 27 Anqing RVs (shown in red), 10 RVs collected in 5 cities of Anhui province between 2012 and 2014 (shown in blue), and 11 2B RVs from other provinces of China during 2011–2014 based on the WHO standard 739-nt window.Genotype 1E and 2B WHO reference strains are indicated by blue triangles.
Mentions: To further understand the transmission of Anqing RVs in Anhui province since 2012, a phylogenetic analysis of Anqing RV sequences, 10 RVs collected in 5 cities of Anhui province between 2012 and 2014 [Wuhu (2012:1; 2013:4), Huainan (2012:1; 2013:1), Bengbu (2014:1), Tongling (2014:1), and Hefei (2014:1)], and 11 2B RVs from other provinces of China collected during 2011–2014 (Fig 6) showed that RVs in Anhui province in 2013 and 2014 could be grouped into genotype 1E (5 RVs from 2 cities in 2013) and 2B (3 RVs from 3 cities in 2014), respectively. Genotype 2B RVs in 2014 clustered separately from all Anqing RVs, and were closely related to 2B RVs from Wuhu and Huainan city in 2012 and from provinces of China other than Anhui, the currently predominant virus circulating in China (unpublished data). These data indicated that after importation, the transmission of Anqing RVs was likely interrupted owing to effective rubella vaccination.

Bottom Line: However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation.After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination.In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

View Article: PubMed Central - PubMed

Affiliation: WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

ABSTRACT
A rubella outbreak occurred in Anqing city of Anhui province, China, from February to July of 2012, and a total of 241 clinically diagnosed or lab-confirmed patients were reported. The highest number of rubella cases during this outbreak was recorded in teenagers between 10 and 19 years of age who had not previously received the rubella vaccine. Genotyping results indicated that the genotype 2B rubella virus (RV) was responsible for the outbreak. However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation. After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination. Strengthening rubella surveillance, including the integration of epidemiologic information and laboratory data, is a vital strategy for rubella control and elimination. In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

No MeSH data available.


Related in: MedlinePlus