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Imported Genotype 2B Rubella Virus Caused the 2012 Outbreak in Anqing City, China.

Zhu Z, Pan G, Zhou S, Dai J, Chen X, Tang J, Chen S, Zheng Y, Song J, Xu W - PLoS ONE (2015)

Bottom Line: However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation.After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination.In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

View Article: PubMed Central - PubMed

Affiliation: WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

ABSTRACT
A rubella outbreak occurred in Anqing city of Anhui province, China, from February to July of 2012, and a total of 241 clinically diagnosed or lab-confirmed patients were reported. The highest number of rubella cases during this outbreak was recorded in teenagers between 10 and 19 years of age who had not previously received the rubella vaccine. Genotyping results indicated that the genotype 2B rubella virus (RV) was responsible for the outbreak. However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation. After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination. Strengthening rubella surveillance, including the integration of epidemiologic information and laboratory data, is a vital strategy for rubella control and elimination. In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

No MeSH data available.


Related in: MedlinePlus

Phylogenetic analysis of the sequences of 27 RVs from the outbreak in Anqing city (shown in red), 14 domestic genotype 2B RVs (2000–2014) (shown in blue), and 50 international genotype 2B RVs (1968–2014) downloaded from the GenBank database based on the WHO standard 739-nt window.
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pone.0139173.g005: Phylogenetic analysis of the sequences of 27 RVs from the outbreak in Anqing city (shown in red), 14 domestic genotype 2B RVs (2000–2014) (shown in blue), and 50 international genotype 2B RVs (1968–2014) downloaded from the GenBank database based on the WHO standard 739-nt window.

Mentions: To investigate the source of the Anqing RVs, a phylogenetic analysis was conducted on the basis of the 739-nt region of 14 domestic genotype 2B RVs (2000–2014) downloaded from the GenBank database and 50 international genotype 2B RVs (1968–2014) including those from Vietnam (9), India (8), United States of America (7), Taiwan (6), United Kingdom (3), Canada (3), Japan (3), Argentina (3), Hong Kong (2), Tunisia (2), Malaysia (1), Brazil (1), Kazakhstan (1), and Israel (1) (Fig 5). The results indicated that Anqing RVs were closely related to an RV from Tunisia in 2011 (strain RVs/Sfax.TUN/16.11/1/2B, GenBank accession no. KF029640), exhibiting the highest nucleotide sequence identity (99.5%–99.8%). In addition, Anqing RVs also clustered with RVs from the United Kingdom isolated in 2012 (strain RVs/Reading.GBR/12.12/1; identity: 99.5%–99.8%; GenBank accession number JX398305) and the United States of America isolated in 2012 (Strain RVi/NewYorkCity.NY.USA/17.12; identity: 99.4%–99.7%; GenBank accession number JX477662; imported from Italy based on GenBank information), with high bootstrap support (90%). These results revealed that the Anqing genotype 2B RVs probably originated from North African or European countries.


Imported Genotype 2B Rubella Virus Caused the 2012 Outbreak in Anqing City, China.

Zhu Z, Pan G, Zhou S, Dai J, Chen X, Tang J, Chen S, Zheng Y, Song J, Xu W - PLoS ONE (2015)

Phylogenetic analysis of the sequences of 27 RVs from the outbreak in Anqing city (shown in red), 14 domestic genotype 2B RVs (2000–2014) (shown in blue), and 50 international genotype 2B RVs (1968–2014) downloaded from the GenBank database based on the WHO standard 739-nt window.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581689&req=5

pone.0139173.g005: Phylogenetic analysis of the sequences of 27 RVs from the outbreak in Anqing city (shown in red), 14 domestic genotype 2B RVs (2000–2014) (shown in blue), and 50 international genotype 2B RVs (1968–2014) downloaded from the GenBank database based on the WHO standard 739-nt window.
Mentions: To investigate the source of the Anqing RVs, a phylogenetic analysis was conducted on the basis of the 739-nt region of 14 domestic genotype 2B RVs (2000–2014) downloaded from the GenBank database and 50 international genotype 2B RVs (1968–2014) including those from Vietnam (9), India (8), United States of America (7), Taiwan (6), United Kingdom (3), Canada (3), Japan (3), Argentina (3), Hong Kong (2), Tunisia (2), Malaysia (1), Brazil (1), Kazakhstan (1), and Israel (1) (Fig 5). The results indicated that Anqing RVs were closely related to an RV from Tunisia in 2011 (strain RVs/Sfax.TUN/16.11/1/2B, GenBank accession no. KF029640), exhibiting the highest nucleotide sequence identity (99.5%–99.8%). In addition, Anqing RVs also clustered with RVs from the United Kingdom isolated in 2012 (strain RVs/Reading.GBR/12.12/1; identity: 99.5%–99.8%; GenBank accession number JX398305) and the United States of America isolated in 2012 (Strain RVi/NewYorkCity.NY.USA/17.12; identity: 99.4%–99.7%; GenBank accession number JX477662; imported from Italy based on GenBank information), with high bootstrap support (90%). These results revealed that the Anqing genotype 2B RVs probably originated from North African or European countries.

Bottom Line: However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation.After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination.In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

View Article: PubMed Central - PubMed

Affiliation: WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

ABSTRACT
A rubella outbreak occurred in Anqing city of Anhui province, China, from February to July of 2012, and a total of 241 clinically diagnosed or lab-confirmed patients were reported. The highest number of rubella cases during this outbreak was recorded in teenagers between 10 and 19 years of age who had not previously received the rubella vaccine. Genotyping results indicated that the genotype 2B rubella virus (RV) was responsible for the outbreak. However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation. After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination. Strengthening rubella surveillance, including the integration of epidemiologic information and laboratory data, is a vital strategy for rubella control and elimination. In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

No MeSH data available.


Related in: MedlinePlus