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Imported Genotype 2B Rubella Virus Caused the 2012 Outbreak in Anqing City, China.

Zhu Z, Pan G, Zhou S, Dai J, Chen X, Tang J, Chen S, Zheng Y, Song J, Xu W - PLoS ONE (2015)

Bottom Line: However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation.After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination.In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

View Article: PubMed Central - PubMed

Affiliation: WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

ABSTRACT
A rubella outbreak occurred in Anqing city of Anhui province, China, from February to July of 2012, and a total of 241 clinically diagnosed or lab-confirmed patients were reported. The highest number of rubella cases during this outbreak was recorded in teenagers between 10 and 19 years of age who had not previously received the rubella vaccine. Genotyping results indicated that the genotype 2B rubella virus (RV) was responsible for the outbreak. However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation. After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination. Strengthening rubella surveillance, including the integration of epidemiologic information and laboratory data, is a vital strategy for rubella control and elimination. In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

No MeSH data available.


Related in: MedlinePlus

Phylogenetic analysis of 27 rubella virus (RV) sequences from the outbreak in Anqing city and 13 RVs from other cities in Anhui province in 2012, as well as the World Health Organization (WHO) reference sequences based on the WHO standard 739-nt window.The 32 WHO reference strains are indicated by blue triangles. The viruses from other cities are indicated by bold italic font. The viruses from 6 counties, 3 districts, and 1 county-level city of Anqing outbreak are indicated by different colors; and the first case of the outbreak is indicated by a red circle.
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pone.0139173.g004: Phylogenetic analysis of 27 rubella virus (RV) sequences from the outbreak in Anqing city and 13 RVs from other cities in Anhui province in 2012, as well as the World Health Organization (WHO) reference sequences based on the WHO standard 739-nt window.The 32 WHO reference strains are indicated by blue triangles. The viruses from other cities are indicated by bold italic font. The viruses from 6 counties, 3 districts, and 1 county-level city of Anqing outbreak are indicated by different colors; and the first case of the outbreak is indicated by a red circle.

Mentions: A phylogenetic analysis of the 739-nt sequences of 27 RVs from the outbreak in Anqing, 13 RVs from another 5 cities in Anhui province collected in the same year [Fuyang (8), Huaibei (1), Huainan (2), Wuhu (1), and Huangshan (1)], and WHO reference viruses showed that these 40 Anhui RV sequences could be divided into 2 genotypes, 1E and 2B. The 27 Anqing RVs, which differed from the RVs of genotype 2B collected in other cities (Wuhu and Huainan city), formed an independent lineage within genotype 2B with high bootstrap support. Thus, the results suggested that genotype 2B RVs responsible for the outbreak and Anqing RVs were different from RVs circulating in other regions of Anhui province in 2012 (Fig 4).


Imported Genotype 2B Rubella Virus Caused the 2012 Outbreak in Anqing City, China.

Zhu Z, Pan G, Zhou S, Dai J, Chen X, Tang J, Chen S, Zheng Y, Song J, Xu W - PLoS ONE (2015)

Phylogenetic analysis of 27 rubella virus (RV) sequences from the outbreak in Anqing city and 13 RVs from other cities in Anhui province in 2012, as well as the World Health Organization (WHO) reference sequences based on the WHO standard 739-nt window.The 32 WHO reference strains are indicated by blue triangles. The viruses from other cities are indicated by bold italic font. The viruses from 6 counties, 3 districts, and 1 county-level city of Anqing outbreak are indicated by different colors; and the first case of the outbreak is indicated by a red circle.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581689&req=5

pone.0139173.g004: Phylogenetic analysis of 27 rubella virus (RV) sequences from the outbreak in Anqing city and 13 RVs from other cities in Anhui province in 2012, as well as the World Health Organization (WHO) reference sequences based on the WHO standard 739-nt window.The 32 WHO reference strains are indicated by blue triangles. The viruses from other cities are indicated by bold italic font. The viruses from 6 counties, 3 districts, and 1 county-level city of Anqing outbreak are indicated by different colors; and the first case of the outbreak is indicated by a red circle.
Mentions: A phylogenetic analysis of the 739-nt sequences of 27 RVs from the outbreak in Anqing, 13 RVs from another 5 cities in Anhui province collected in the same year [Fuyang (8), Huaibei (1), Huainan (2), Wuhu (1), and Huangshan (1)], and WHO reference viruses showed that these 40 Anhui RV sequences could be divided into 2 genotypes, 1E and 2B. The 27 Anqing RVs, which differed from the RVs of genotype 2B collected in other cities (Wuhu and Huainan city), formed an independent lineage within genotype 2B with high bootstrap support. Thus, the results suggested that genotype 2B RVs responsible for the outbreak and Anqing RVs were different from RVs circulating in other regions of Anhui province in 2012 (Fig 4).

Bottom Line: However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation.After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination.In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

View Article: PubMed Central - PubMed

Affiliation: WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

ABSTRACT
A rubella outbreak occurred in Anqing city of Anhui province, China, from February to July of 2012, and a total of 241 clinically diagnosed or lab-confirmed patients were reported. The highest number of rubella cases during this outbreak was recorded in teenagers between 10 and 19 years of age who had not previously received the rubella vaccine. Genotyping results indicated that the genotype 2B rubella virus (RV) was responsible for the outbreak. However, a phylogenetic analysis showed that the genotype 2B RVs isolated in Anqing City were not related to 2B RVs found in other cities of Anhui province and in other provinces of China, thus providing evidence for importation. After importation, the transmission of Anqing RVs was interrupted owing to an effective immunization campaign against rubella, suggesting the timeliness and effectiveness of contingency vaccination. Strengthening rubella surveillance, including the integration of epidemiologic information and laboratory data, is a vital strategy for rubella control and elimination. In addition, except for routine immunization, targeted supplementary immunization activities aimed at susceptible groups according to sero-epidemiological surveillance data also play a key role in stopping the continuous transmission of rubella viruses and in preventing further congenital rubella syndrome cases.

No MeSH data available.


Related in: MedlinePlus