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Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

Jadoon S, Karim S, Bin Asad MH, Akram MR, Khan AK, Malik A, Chen C, Murtaza G - Oxid Med Cell Longev (2015)

Bottom Line: These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR.The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents.Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Natural Resources Engineering and Management, University of Kurdistan, Hewler 44003, Iraq.

ABSTRACT
The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

No MeSH data available.


Related in: MedlinePlus

Classification of phytoantioxidants [15].
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig4: Classification of phytoantioxidants [15].

Mentions: The phyto-kingdom includes vegetables, fruits, whole grains, and beverages, for example, tea, chocolate, and wine. These products are rich in natural antioxidants. An important class of natural exogenous antioxidants is phytoantioxidants, that is, antioxidants found in plants [21]. Phytoantioxidants include terpenes or polyphenols (Figure 4). After synthesis in plants, these compounds are found to have important role in the metabolism and defense system of plants. Terpenes are known to have potential for managing the oxidative stress through their free radical scavenging potential. Moreover, polyphenols occur in all parts (roots to leaves) of the plants and protect them from environmental stress through their free radical scavenging property. There are various types (>8000 phenolic structures) of polyphenols on the basis of molecular weight and polarity [64]. The structural formula of polyphenols contains phenol group(s), that is, benzene ring possessing hydroxyl group. The antioxidant activity of various polyphenols depends on number and position of phenol groups [65].


Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

Jadoon S, Karim S, Bin Asad MH, Akram MR, Khan AK, Malik A, Chen C, Murtaza G - Oxid Med Cell Longev (2015)

Classification of phytoantioxidants [15].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4581564&req=5

fig4: Classification of phytoantioxidants [15].
Mentions: The phyto-kingdom includes vegetables, fruits, whole grains, and beverages, for example, tea, chocolate, and wine. These products are rich in natural antioxidants. An important class of natural exogenous antioxidants is phytoantioxidants, that is, antioxidants found in plants [21]. Phytoantioxidants include terpenes or polyphenols (Figure 4). After synthesis in plants, these compounds are found to have important role in the metabolism and defense system of plants. Terpenes are known to have potential for managing the oxidative stress through their free radical scavenging potential. Moreover, polyphenols occur in all parts (roots to leaves) of the plants and protect them from environmental stress through their free radical scavenging property. There are various types (>8000 phenolic structures) of polyphenols on the basis of molecular weight and polarity [64]. The structural formula of polyphenols contains phenol group(s), that is, benzene ring possessing hydroxyl group. The antioxidant activity of various polyphenols depends on number and position of phenol groups [65].

Bottom Line: These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR.The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents.Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Natural Resources Engineering and Management, University of Kurdistan, Hewler 44003, Iraq.

ABSTRACT
The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

No MeSH data available.


Related in: MedlinePlus