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Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

Jadoon S, Karim S, Bin Asad MH, Akram MR, Khan AK, Malik A, Chen C, Murtaza G - Oxid Med Cell Longev (2015)

Bottom Line: These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR.The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents.Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Natural Resources Engineering and Management, University of Kurdistan, Hewler 44003, Iraq.

ABSTRACT
The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

No MeSH data available.


Related in: MedlinePlus

Production of ROS and its role in the initiation of oxidative chain reactions and target sites for antioxidant action.
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Related In: Results  -  Collection


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fig3: Production of ROS and its role in the initiation of oxidative chain reactions and target sites for antioxidant action.

Mentions: The exposure to UVR is the main cause of oxidative stress in the skin and thus is an important risk factor for development of skin problems, for example, wrinkle formation, lesions, and cancer. On exposure to sunlight, skin molecules absorb UVR resulting in the generation of reactive oxygen species (ROS). There are two types of ROS: type 1 consists of a single, excited oxygen molecule (1O2) (Figure 3), while oxygen molecules with unpaired electron constitute second type of ROS. The examples of second type are presented in Table 1 that also describes the enzymes which are involved in the generation of these ROS [16]. Reactive oxygen entities exert a damaging effect on cellular fractions including cell walls, lipid membranes, mitochondria, nucleus, and DNA producing “oxidative stress,” that is, a difference between ROS and antioxidants, ROS being in excess leading to tissue injury and development of disease including aging, cancer, ischemia, liver injury, arthritis, and Parkinson's syndrome (Figure 2).


Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

Jadoon S, Karim S, Bin Asad MH, Akram MR, Khan AK, Malik A, Chen C, Murtaza G - Oxid Med Cell Longev (2015)

Production of ROS and its role in the initiation of oxidative chain reactions and target sites for antioxidant action.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4581564&req=5

fig3: Production of ROS and its role in the initiation of oxidative chain reactions and target sites for antioxidant action.
Mentions: The exposure to UVR is the main cause of oxidative stress in the skin and thus is an important risk factor for development of skin problems, for example, wrinkle formation, lesions, and cancer. On exposure to sunlight, skin molecules absorb UVR resulting in the generation of reactive oxygen species (ROS). There are two types of ROS: type 1 consists of a single, excited oxygen molecule (1O2) (Figure 3), while oxygen molecules with unpaired electron constitute second type of ROS. The examples of second type are presented in Table 1 that also describes the enzymes which are involved in the generation of these ROS [16]. Reactive oxygen entities exert a damaging effect on cellular fractions including cell walls, lipid membranes, mitochondria, nucleus, and DNA producing “oxidative stress,” that is, a difference between ROS and antioxidants, ROS being in excess leading to tissue injury and development of disease including aging, cancer, ischemia, liver injury, arthritis, and Parkinson's syndrome (Figure 2).

Bottom Line: These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR.The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents.Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Natural Resources Engineering and Management, University of Kurdistan, Hewler 44003, Iraq.

ABSTRACT
The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

No MeSH data available.


Related in: MedlinePlus