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Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury.

Strazzer S, Rocca MA, Molteni E, De Meo E, Recla M, Valsasina P, Arrigoni F, Galbiati S, Bardoni A, Filippi M - Neural Plast. (2015)

Bottom Line: With increasing task demand, compared to controls, ABI patients had an impaired ability to increase the recruitment of several posterior regions of the attention network.Such abnormal brain recruitment was significantly influenced by the type of lesion (focal versus diffuse axonal injury) and time elapsed from the event.Pediatric ABI patients experienced an inability to optimize attention network recruitment, especially when task difficulty was increased, which likely contributes to their clinical and cognitive deficits.

View Article: PubMed Central - PubMed

Affiliation: Acquired Brain Injury Unit, Scientific Institute "Eugenio Medea", Via Don Luigi Monza 20, 23842 Bosisio Parini, Italy.

ABSTRACT
We assessed abnormalities of brain functional magnetic resonance imaging (fMRI) activity during a sustained attention task (Conners' Continuous Performance Test (CCPT)) in 20 right-handed pediatric acquired brain injury (ABI) patients versus 7 right-handed age-matched healthy controls, and we estimated the correlation of such abnormalities with clinical and cognitive deficits. Patients underwent the Wechsler Intelligence Scale for Children (WISC), Wisconsin Card Sorting Test, and Functional Independence Measure (FIM) evaluations. During fMRI, patients and controls activated regions of the attention network. Compared to controls, ABI patients experienced a decreased average fMRI recruitment of the left cerebellum and a decreased deactivation of the left anterior cingulate cortex. With increasing task demand, compared to controls, ABI patients had an impaired ability to increase the recruitment of several posterior regions of the attention network. They also experienced a greater activation of frontal regions, which was correlated with worse performance on FIM, WISC, and fMRI CCPT. Such abnormal brain recruitment was significantly influenced by the type of lesion (focal versus diffuse axonal injury) and time elapsed from the event. Pediatric ABI patients experienced an inability to optimize attention network recruitment, especially when task difficulty was increased, which likely contributes to their clinical and cognitive deficits.

No MeSH data available.


Related in: MedlinePlus

Correlations (p < 0.001) between increased functional magnetic resonance imaging activation of the right superior frontal gyrus (SFG) (a) during the load fMRI condition of the Conners Continuous Performance Test (CCPT) in acquired brain injury patients versus (b) Functional Independent Measure (FIM) scores; (c) the percentage of correct responses during CCPT; and (d) Wechsler Intelligence Scale for Children (WISC-III) score.
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fig4: Correlations (p < 0.001) between increased functional magnetic resonance imaging activation of the right superior frontal gyrus (SFG) (a) during the load fMRI condition of the Conners Continuous Performance Test (CCPT) in acquired brain injury patients versus (b) Functional Independent Measure (FIM) scores; (c) the percentage of correct responses during CCPT; and (d) Wechsler Intelligence Scale for Children (WISC-III) score.

Mentions: increased activation of the right SFG during the load condition and worse scores at FIM (r = −0.73), WISC-III (FSIQ) (r = −0.72), WISC-III (PIQ) (r = −0.71), and WISC-III (VIQ) (r = −0.69), as well as with a lower percentage of correct responses (r = −0.69) at CCPT (Figure 4);


Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury.

Strazzer S, Rocca MA, Molteni E, De Meo E, Recla M, Valsasina P, Arrigoni F, Galbiati S, Bardoni A, Filippi M - Neural Plast. (2015)

Correlations (p < 0.001) between increased functional magnetic resonance imaging activation of the right superior frontal gyrus (SFG) (a) during the load fMRI condition of the Conners Continuous Performance Test (CCPT) in acquired brain injury patients versus (b) Functional Independent Measure (FIM) scores; (c) the percentage of correct responses during CCPT; and (d) Wechsler Intelligence Scale for Children (WISC-III) score.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4581560&req=5

fig4: Correlations (p < 0.001) between increased functional magnetic resonance imaging activation of the right superior frontal gyrus (SFG) (a) during the load fMRI condition of the Conners Continuous Performance Test (CCPT) in acquired brain injury patients versus (b) Functional Independent Measure (FIM) scores; (c) the percentage of correct responses during CCPT; and (d) Wechsler Intelligence Scale for Children (WISC-III) score.
Mentions: increased activation of the right SFG during the load condition and worse scores at FIM (r = −0.73), WISC-III (FSIQ) (r = −0.72), WISC-III (PIQ) (r = −0.71), and WISC-III (VIQ) (r = −0.69), as well as with a lower percentage of correct responses (r = −0.69) at CCPT (Figure 4);

Bottom Line: With increasing task demand, compared to controls, ABI patients had an impaired ability to increase the recruitment of several posterior regions of the attention network.Such abnormal brain recruitment was significantly influenced by the type of lesion (focal versus diffuse axonal injury) and time elapsed from the event.Pediatric ABI patients experienced an inability to optimize attention network recruitment, especially when task difficulty was increased, which likely contributes to their clinical and cognitive deficits.

View Article: PubMed Central - PubMed

Affiliation: Acquired Brain Injury Unit, Scientific Institute "Eugenio Medea", Via Don Luigi Monza 20, 23842 Bosisio Parini, Italy.

ABSTRACT
We assessed abnormalities of brain functional magnetic resonance imaging (fMRI) activity during a sustained attention task (Conners' Continuous Performance Test (CCPT)) in 20 right-handed pediatric acquired brain injury (ABI) patients versus 7 right-handed age-matched healthy controls, and we estimated the correlation of such abnormalities with clinical and cognitive deficits. Patients underwent the Wechsler Intelligence Scale for Children (WISC), Wisconsin Card Sorting Test, and Functional Independence Measure (FIM) evaluations. During fMRI, patients and controls activated regions of the attention network. Compared to controls, ABI patients experienced a decreased average fMRI recruitment of the left cerebellum and a decreased deactivation of the left anterior cingulate cortex. With increasing task demand, compared to controls, ABI patients had an impaired ability to increase the recruitment of several posterior regions of the attention network. They also experienced a greater activation of frontal regions, which was correlated with worse performance on FIM, WISC, and fMRI CCPT. Such abnormal brain recruitment was significantly influenced by the type of lesion (focal versus diffuse axonal injury) and time elapsed from the event. Pediatric ABI patients experienced an inability to optimize attention network recruitment, especially when task difficulty was increased, which likely contributes to their clinical and cognitive deficits.

No MeSH data available.


Related in: MedlinePlus