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The Effect of Aerobic Exercise in Ambient Particulate Matter on Lung Tissue Inflammation and Lung Cancer.

Fashi M, Agha Alinejad H, Asilian Mahabadi H - Iran J Cancer Prev (2015)

Bottom Line: In order to determine the significant differences between groups, one way ANOVA and LSD post hoc and Kruskal-Vallis test were used.But there was significant different only between B and C groups for TNF-α and NF-κB (P = 0.047, 0.014, respectively).We conclude that four week aerobic exercise presents protective effects in a rat model of PM10 carbon black-induced lung inflammation and risk of lung cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Education and Sports Sciences, Tarbiat Modares University, Tehran, IR Iran.

ABSTRACT

Background: Exposure to Air pollution PM10 results in lung inflammation increased risk of lung cancer. Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the pulmonary response to PM10 have not been investigated.

Objectives: The present study evaluated the effect of aerobic exercise on the lung inflammatory and risk of lung cancer of rat exposed to PM10 carbon black.

Materials and methods: Twenty four adult male Wistar rats were divided into 4 groups: A: control (without exposure PM10 and aerobic exercise; n = 6), B: aerobic exercise (five times per week for 4 weeks; n = 6), C: exposure to PM10 carbon black (5 mg/m(3); per rat; n = 6), D: and aerobic exercise concomitantly with exposure to PM10 carbon black (n = 6). The gene expression of TLR4, NF-κB and TNF-α were analyzed in lung tissue by Real time-PCR. In order to determine the significant differences between groups, one way ANOVA and LSD post hoc and Kruskal-Vallis test were used.

Results: Aerobic exercise inhibited the PM10 -induced increase in the gene expression of TLR4, NF-κB and TNF-α. But there was significant different only between B and C groups for TNF-α and NF-κB (P = 0.047, 0.014, respectively).

Conclusions: We conclude that four week aerobic exercise presents protective effects in a rat model of PM10 carbon black-induced lung inflammation and risk of lung cancer. Our results indicate a need for human studies that evaluate the lung Responses to aerobic exercise chronically performed in polluted areas.

No MeSH data available.


Related in: MedlinePlus

Effects of Aerobic Exercise and Carbon Black PM10 Exposure on Gene Expression TLR4, NF- κB and TNF-αAsterisk Indicates Treatments That are Significantly Different at P ≤ 0.05 Compared With all of the Groups.
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A2333FIG2: Effects of Aerobic Exercise and Carbon Black PM10 Exposure on Gene Expression TLR4, NF- κB and TNF-αAsterisk Indicates Treatments That are Significantly Different at P ≤ 0.05 Compared With all of the Groups.

Mentions: Presented data in Figure 2 demonstrate that PM10 carbon black exposure increased the gene expression TLR4, NF-κB and TNF-α in lung tissue compared with all of the other groups (P ≤ 0.05) and that aerobic exercise in carbon black PM10 exposure decreased the expression of these cytokine compared with the carbon black PM10 exposure group (P ≤ 0.05). 0ne way ANOVA also demonstrated that carbon black PM10 exposure presented a significant effect on the TNF-α (P = 0.047) and NF-κB (P = 0.014). No significant effect was observed on the gene expression TLR4 by Kruskal-Vallis test (P = 0.325).


The Effect of Aerobic Exercise in Ambient Particulate Matter on Lung Tissue Inflammation and Lung Cancer.

Fashi M, Agha Alinejad H, Asilian Mahabadi H - Iran J Cancer Prev (2015)

Effects of Aerobic Exercise and Carbon Black PM10 Exposure on Gene Expression TLR4, NF- κB and TNF-αAsterisk Indicates Treatments That are Significantly Different at P ≤ 0.05 Compared With all of the Groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581364&req=5

A2333FIG2: Effects of Aerobic Exercise and Carbon Black PM10 Exposure on Gene Expression TLR4, NF- κB and TNF-αAsterisk Indicates Treatments That are Significantly Different at P ≤ 0.05 Compared With all of the Groups.
Mentions: Presented data in Figure 2 demonstrate that PM10 carbon black exposure increased the gene expression TLR4, NF-κB and TNF-α in lung tissue compared with all of the other groups (P ≤ 0.05) and that aerobic exercise in carbon black PM10 exposure decreased the expression of these cytokine compared with the carbon black PM10 exposure group (P ≤ 0.05). 0ne way ANOVA also demonstrated that carbon black PM10 exposure presented a significant effect on the TNF-α (P = 0.047) and NF-κB (P = 0.014). No significant effect was observed on the gene expression TLR4 by Kruskal-Vallis test (P = 0.325).

Bottom Line: In order to determine the significant differences between groups, one way ANOVA and LSD post hoc and Kruskal-Vallis test were used.But there was significant different only between B and C groups for TNF-α and NF-κB (P = 0.047, 0.014, respectively).We conclude that four week aerobic exercise presents protective effects in a rat model of PM10 carbon black-induced lung inflammation and risk of lung cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Education and Sports Sciences, Tarbiat Modares University, Tehran, IR Iran.

ABSTRACT

Background: Exposure to Air pollution PM10 results in lung inflammation increased risk of lung cancer. Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the pulmonary response to PM10 have not been investigated.

Objectives: The present study evaluated the effect of aerobic exercise on the lung inflammatory and risk of lung cancer of rat exposed to PM10 carbon black.

Materials and methods: Twenty four adult male Wistar rats were divided into 4 groups: A: control (without exposure PM10 and aerobic exercise; n = 6), B: aerobic exercise (five times per week for 4 weeks; n = 6), C: exposure to PM10 carbon black (5 mg/m(3); per rat; n = 6), D: and aerobic exercise concomitantly with exposure to PM10 carbon black (n = 6). The gene expression of TLR4, NF-κB and TNF-α were analyzed in lung tissue by Real time-PCR. In order to determine the significant differences between groups, one way ANOVA and LSD post hoc and Kruskal-Vallis test were used.

Results: Aerobic exercise inhibited the PM10 -induced increase in the gene expression of TLR4, NF-κB and TNF-α. But there was significant different only between B and C groups for TNF-α and NF-κB (P = 0.047, 0.014, respectively).

Conclusions: We conclude that four week aerobic exercise presents protective effects in a rat model of PM10 carbon black-induced lung inflammation and risk of lung cancer. Our results indicate a need for human studies that evaluate the lung Responses to aerobic exercise chronically performed in polluted areas.

No MeSH data available.


Related in: MedlinePlus