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Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.

Wang J, Song YX, Ma B, Wang JJ, Sun JX, Chen XW, Zhao JH, Yang YC, Wang ZN - Int J Mol Sci (2015)

Bottom Line: Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes.An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer.The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.

ABSTRACT
Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

No MeSH data available.


Related in: MedlinePlus

The biological mechanisms of MALAT1 in CRC. Resveratrol could suppress CRC cell invasion and migration by inhibiting Wnt/β-catenin signaling pathway through downregulating MALAT1; MALAT1 might promote CRC development via targeting AKAP-9; MALAT1 could bind to SFPQ and release PTBP2 from the SFPQ/PTBP2 complex that promotes tumor growth and migration.
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ijms-16-19886-f004: The biological mechanisms of MALAT1 in CRC. Resveratrol could suppress CRC cell invasion and migration by inhibiting Wnt/β-catenin signaling pathway through downregulating MALAT1; MALAT1 might promote CRC development via targeting AKAP-9; MALAT1 could bind to SFPQ and release PTBP2 from the SFPQ/PTBP2 complex that promotes tumor growth and migration.

Mentions: Resveratrol, which is extracted from the Chinese herbal medicine “polygonum cuspidatum”, has been suggested as a new Chinese medicine monomer anticancer drug for different cancers [126,127]. Furthermore, it has been shown to be effective against CRC through the caspase/cyclin-CDK pathways [128] and the TGF-β1/Smads signaling pathway [129]. It significantly inhibited the expression of MALAT1 in LoVo cells by directly inhibiting the promoter activity of MALAT1, and it inhibited cell proliferation, invasion, and migration in a dose-dependent manner in CRC. The expression of MALAT1 was statistically significantly associated with clinicopathological features including metastasis and invasion. MALAT1 was shown to increase the cytoplasmic levels of β-catenin, concomitant with the downregulation of its nuclear expression. The knockdown of MALAT1 could downregulate the expression of β-catenin downstream target genes such as c-myc and MMP-7. Resveratrol suppressed CRC cell invasion and migration by inhibiting the Wnt/β-catenin signaling pathway through the downregulation of MALAT1 [130] (Figure 4).


Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.

Wang J, Song YX, Ma B, Wang JJ, Sun JX, Chen XW, Zhao JH, Yang YC, Wang ZN - Int J Mol Sci (2015)

The biological mechanisms of MALAT1 in CRC. Resveratrol could suppress CRC cell invasion and migration by inhibiting Wnt/β-catenin signaling pathway through downregulating MALAT1; MALAT1 might promote CRC development via targeting AKAP-9; MALAT1 could bind to SFPQ and release PTBP2 from the SFPQ/PTBP2 complex that promotes tumor growth and migration.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581331&req=5

ijms-16-19886-f004: The biological mechanisms of MALAT1 in CRC. Resveratrol could suppress CRC cell invasion and migration by inhibiting Wnt/β-catenin signaling pathway through downregulating MALAT1; MALAT1 might promote CRC development via targeting AKAP-9; MALAT1 could bind to SFPQ and release PTBP2 from the SFPQ/PTBP2 complex that promotes tumor growth and migration.
Mentions: Resveratrol, which is extracted from the Chinese herbal medicine “polygonum cuspidatum”, has been suggested as a new Chinese medicine monomer anticancer drug for different cancers [126,127]. Furthermore, it has been shown to be effective against CRC through the caspase/cyclin-CDK pathways [128] and the TGF-β1/Smads signaling pathway [129]. It significantly inhibited the expression of MALAT1 in LoVo cells by directly inhibiting the promoter activity of MALAT1, and it inhibited cell proliferation, invasion, and migration in a dose-dependent manner in CRC. The expression of MALAT1 was statistically significantly associated with clinicopathological features including metastasis and invasion. MALAT1 was shown to increase the cytoplasmic levels of β-catenin, concomitant with the downregulation of its nuclear expression. The knockdown of MALAT1 could downregulate the expression of β-catenin downstream target genes such as c-myc and MMP-7. Resveratrol suppressed CRC cell invasion and migration by inhibiting the Wnt/β-catenin signaling pathway through the downregulation of MALAT1 [130] (Figure 4).

Bottom Line: Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes.An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer.The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.

ABSTRACT
Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

No MeSH data available.


Related in: MedlinePlus