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Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.

Wang J, Song YX, Ma B, Wang JJ, Sun JX, Chen XW, Zhao JH, Yang YC, Wang ZN - Int J Mol Sci (2015)

Bottom Line: Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes.An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer.The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.

ABSTRACT
Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

No MeSH data available.


Related in: MedlinePlus

Representative oncogenic miRNAs and their target genes in CRC.
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ijms-16-19886-f002: Representative oncogenic miRNAs and their target genes in CRC.

Mentions: Accumulating evidence suggests that miRNAs are aberrantly expressed in CRC and may serve as oncogenes or tumor suppressors depending on their downstream targets or associated signaling pathways [18]. Certain oncogenic miRNAs, such as miR-18a, -21, -31, and -92a, are involved in the development and progression of CRC (Figure 2).


Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.

Wang J, Song YX, Ma B, Wang JJ, Sun JX, Chen XW, Zhao JH, Yang YC, Wang ZN - Int J Mol Sci (2015)

Representative oncogenic miRNAs and their target genes in CRC.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581331&req=5

ijms-16-19886-f002: Representative oncogenic miRNAs and their target genes in CRC.
Mentions: Accumulating evidence suggests that miRNAs are aberrantly expressed in CRC and may serve as oncogenes or tumor suppressors depending on their downstream targets or associated signaling pathways [18]. Certain oncogenic miRNAs, such as miR-18a, -21, -31, and -92a, are involved in the development and progression of CRC (Figure 2).

Bottom Line: Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes.An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer.The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.

ABSTRACT
Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

No MeSH data available.


Related in: MedlinePlus