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Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.

Wang J, Song YX, Ma B, Wang JJ, Sun JX, Chen XW, Zhao JH, Yang YC, Wang ZN - Int J Mol Sci (2015)

Bottom Line: Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes.An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer.The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.

ABSTRACT
Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

No MeSH data available.


Related in: MedlinePlus

Five categories of lncRNAs. According to the position in the genome, they can generally be classified into the following categories: intergenic, intronic, bidirectional, sense, and antisense lncRNAs.
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ijms-16-19886-f001: Five categories of lncRNAs. According to the position in the genome, they can generally be classified into the following categories: intergenic, intronic, bidirectional, sense, and antisense lncRNAs.

Mentions: The ncRNAs can be systematically classified into two groups according to size, namely small ncRNAs (sncRNAs), which are shorter than 200 nucleotides (nt), and long ncRNAs (lncRNAs), which are longer than 200 nt. The sncRNAs can be divided into microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs), PIWI-interacting RNAs (piRNAs), and other sncRNAs. The classification of lncRNAs is based on four major characteristics, namely genomic location and context, effect exerted on DNA sequences, mechanism of action, and their targeting mechanism [7]. In addition, they can generally be classified into the following categories: intergenic, intronic, bidirectional, sense, and antisense lncRNAs [8] (Figure 1).


Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.

Wang J, Song YX, Ma B, Wang JJ, Sun JX, Chen XW, Zhao JH, Yang YC, Wang ZN - Int J Mol Sci (2015)

Five categories of lncRNAs. According to the position in the genome, they can generally be classified into the following categories: intergenic, intronic, bidirectional, sense, and antisense lncRNAs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581331&req=5

ijms-16-19886-f001: Five categories of lncRNAs. According to the position in the genome, they can generally be classified into the following categories: intergenic, intronic, bidirectional, sense, and antisense lncRNAs.
Mentions: The ncRNAs can be systematically classified into two groups according to size, namely small ncRNAs (sncRNAs), which are shorter than 200 nucleotides (nt), and long ncRNAs (lncRNAs), which are longer than 200 nt. The sncRNAs can be divided into microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs), PIWI-interacting RNAs (piRNAs), and other sncRNAs. The classification of lncRNAs is based on four major characteristics, namely genomic location and context, effect exerted on DNA sequences, mechanism of action, and their targeting mechanism [7]. In addition, they can generally be classified into the following categories: intergenic, intronic, bidirectional, sense, and antisense lncRNAs [8] (Figure 1).

Bottom Line: Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes.An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer.The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.

ABSTRACT
Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

No MeSH data available.


Related in: MedlinePlus