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Polymer/Iron Oxide Nanoparticle Composites--A Straight Forward and Scalable Synthesis Approach.

Sommertune J, Sugunan A, Ahniyaz A, Bejhed RS, Sarwe A, Johansson C, Balceris C, Ludwig F, Posth O, Fornara A - Int J Mol Sci (2015)

Bottom Line: Multi-core particles were obtained within the Z-average size range of 130 to 340 nm.With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles.The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

View Article: PubMed Central - PubMed

Affiliation: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. jens.sommertune@sp.se.

ABSTRACT
Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

No MeSH data available.


Related in: MedlinePlus

Schematic formation of SPION/polymer hybrid particle, starting from an oil in water emulsion droplet (left), proceeding with a high polymer concentration droplet (middle) and the formation of a solid polymer sphere with trapped SPIONs (right).
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ijms-16-19752-f011: Schematic formation of SPION/polymer hybrid particle, starting from an oil in water emulsion droplet (left), proceeding with a high polymer concentration droplet (middle) and the formation of a solid polymer sphere with trapped SPIONs (right).

Mentions: Following, the SPION/chloroform dispersion was used as the polymer solvent/oil phase in the emulsion solvent evaporation process (ESE), schematically shown in Figure 11.


Polymer/Iron Oxide Nanoparticle Composites--A Straight Forward and Scalable Synthesis Approach.

Sommertune J, Sugunan A, Ahniyaz A, Bejhed RS, Sarwe A, Johansson C, Balceris C, Ludwig F, Posth O, Fornara A - Int J Mol Sci (2015)

Schematic formation of SPION/polymer hybrid particle, starting from an oil in water emulsion droplet (left), proceeding with a high polymer concentration droplet (middle) and the formation of a solid polymer sphere with trapped SPIONs (right).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581323&req=5

ijms-16-19752-f011: Schematic formation of SPION/polymer hybrid particle, starting from an oil in water emulsion droplet (left), proceeding with a high polymer concentration droplet (middle) and the formation of a solid polymer sphere with trapped SPIONs (right).
Mentions: Following, the SPION/chloroform dispersion was used as the polymer solvent/oil phase in the emulsion solvent evaporation process (ESE), schematically shown in Figure 11.

Bottom Line: Multi-core particles were obtained within the Z-average size range of 130 to 340 nm.With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles.The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

View Article: PubMed Central - PubMed

Affiliation: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. jens.sommertune@sp.se.

ABSTRACT
Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

No MeSH data available.


Related in: MedlinePlus