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Polymer/Iron Oxide Nanoparticle Composites--A Straight Forward and Scalable Synthesis Approach.

Sommertune J, Sugunan A, Ahniyaz A, Bejhed RS, Sarwe A, Johansson C, Balceris C, Ludwig F, Posth O, Fornara A - Int J Mol Sci (2015)

Bottom Line: Multi-core particles were obtained within the Z-average size range of 130 to 340 nm.With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles.The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

View Article: PubMed Central - PubMed

Affiliation: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. jens.sommertune@sp.se.

ABSTRACT
Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

No MeSH data available.


Related in: MedlinePlus

TGA curves of aqueous dispersions (full line) and dried particles (dotted line) of Sample A (blue) and Sample B (red).
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ijms-16-19752-f005: TGA curves of aqueous dispersions (full line) and dried particles (dotted line) of Sample A (blue) and Sample B (red).

Mentions: The thermal decomposition (see Figure 5) shows that Sample A and B show different amounts of polymer, stabilizers, and iron oxide in the dispersions. Whereas Sample A contains about 96.6 wt % water, Sample B contains ~98.6 wt % water. This can be explained by varying efficiency of the magnetic collection. However, looking at the dried samples (dotted lines in Figure 5), the analysis shows that Sample A consists of ~15 wt % stabilizer, ~45 wt % PS, and ~39 wt % SPION. Sample B on the other hand has a somewhat higher polymer amount (~53 wt %), ~12 wt % stabilizer and ~35 wt % SPION. The TGA curves clearly show the lower heat stability of PLA as compared to PS.


Polymer/Iron Oxide Nanoparticle Composites--A Straight Forward and Scalable Synthesis Approach.

Sommertune J, Sugunan A, Ahniyaz A, Bejhed RS, Sarwe A, Johansson C, Balceris C, Ludwig F, Posth O, Fornara A - Int J Mol Sci (2015)

TGA curves of aqueous dispersions (full line) and dried particles (dotted line) of Sample A (blue) and Sample B (red).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581323&req=5

ijms-16-19752-f005: TGA curves of aqueous dispersions (full line) and dried particles (dotted line) of Sample A (blue) and Sample B (red).
Mentions: The thermal decomposition (see Figure 5) shows that Sample A and B show different amounts of polymer, stabilizers, and iron oxide in the dispersions. Whereas Sample A contains about 96.6 wt % water, Sample B contains ~98.6 wt % water. This can be explained by varying efficiency of the magnetic collection. However, looking at the dried samples (dotted lines in Figure 5), the analysis shows that Sample A consists of ~15 wt % stabilizer, ~45 wt % PS, and ~39 wt % SPION. Sample B on the other hand has a somewhat higher polymer amount (~53 wt %), ~12 wt % stabilizer and ~35 wt % SPION. The TGA curves clearly show the lower heat stability of PLA as compared to PS.

Bottom Line: Multi-core particles were obtained within the Z-average size range of 130 to 340 nm.With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles.The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

View Article: PubMed Central - PubMed

Affiliation: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. jens.sommertune@sp.se.

ABSTRACT
Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

No MeSH data available.


Related in: MedlinePlus