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Polymer/Iron Oxide Nanoparticle Composites--A Straight Forward and Scalable Synthesis Approach.

Sommertune J, Sugunan A, Ahniyaz A, Bejhed RS, Sarwe A, Johansson C, Balceris C, Ludwig F, Posth O, Fornara A - Int J Mol Sci (2015)

Bottom Line: Multi-core particles were obtained within the Z-average size range of 130 to 340 nm.With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles.The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

View Article: PubMed Central - PubMed

Affiliation: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. jens.sommertune@sp.se.

ABSTRACT
Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

No MeSH data available.


Related in: MedlinePlus

(a) Representative TEM (Transmission electron microscope) image of the SPION cores; (b) Size histogram generated from particle size analyses from several TEM images; (c) High-resolution TEM image showing well developed lattice fringes.
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ijms-16-19752-f001: (a) Representative TEM (Transmission electron microscope) image of the SPION cores; (b) Size histogram generated from particle size analyses from several TEM images; (c) High-resolution TEM image showing well developed lattice fringes.

Mentions: Transmission electron microscope (TEM) images show that the SPIONs are well crystallized and have a small size. Image analysis from multiple TEM images show that the nanoparticles have mean size of about 6 nm (Figure 1). High-resolution TEM show well developed lattice fringes, showing good crystallinity. The small size is indicative of superparamagnetic behavior. Nevertheless, there is empirical evidence that small crystal size leads to low magnetic moments in SPIONs due to dominance of surface effects [19]. However, increasing the crystal size to increase their magnetic moments leads to dominance of Brownian relaxation over Néel relaxation; in other words loss of super-paramagnetic behavior.


Polymer/Iron Oxide Nanoparticle Composites--A Straight Forward and Scalable Synthesis Approach.

Sommertune J, Sugunan A, Ahniyaz A, Bejhed RS, Sarwe A, Johansson C, Balceris C, Ludwig F, Posth O, Fornara A - Int J Mol Sci (2015)

(a) Representative TEM (Transmission electron microscope) image of the SPION cores; (b) Size histogram generated from particle size analyses from several TEM images; (c) High-resolution TEM image showing well developed lattice fringes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581323&req=5

ijms-16-19752-f001: (a) Representative TEM (Transmission electron microscope) image of the SPION cores; (b) Size histogram generated from particle size analyses from several TEM images; (c) High-resolution TEM image showing well developed lattice fringes.
Mentions: Transmission electron microscope (TEM) images show that the SPIONs are well crystallized and have a small size. Image analysis from multiple TEM images show that the nanoparticles have mean size of about 6 nm (Figure 1). High-resolution TEM show well developed lattice fringes, showing good crystallinity. The small size is indicative of superparamagnetic behavior. Nevertheless, there is empirical evidence that small crystal size leads to low magnetic moments in SPIONs due to dominance of surface effects [19]. However, increasing the crystal size to increase their magnetic moments leads to dominance of Brownian relaxation over Néel relaxation; in other words loss of super-paramagnetic behavior.

Bottom Line: Multi-core particles were obtained within the Z-average size range of 130 to 340 nm.With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles.The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

View Article: PubMed Central - PubMed

Affiliation: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. jens.sommertune@sp.se.

ABSTRACT
Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

No MeSH data available.


Related in: MedlinePlus