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Chitosan in Molecularly-Imprinted Polymers: Current and Future Prospects.

Xu L, Huang YA, Zhu QJ, Ye C - Int J Mol Sci (2015)

Bottom Line: These extensive applications are due to the polymers' desired selectivity, physical robustness, and thermal stability, as well as their low cost and easy preparation.Cross-linkers, which fix the functional groups of chitosan around imprinted molecules, play an important role in chitosan molecularly-imprinted polymers.Finally, some significant attempts to further develop the application of chitosan in MIT are proposed.

View Article: PubMed Central - PubMed

Affiliation: School of Liquor & Food Engineering, Guizhou University, Guiyang 550025, China. xulong19891026@163.com.

ABSTRACT
Chitosan is widely used in molecular imprinting technology (MIT) as a functional monomer or supporting matrix because of its low cost and high contents of amino and hydroxyl functional groups. The various excellent properties of chitosan, which include nontoxicity, biodegradability, biocompatibility, and attractive physical and mechanical performances, make chitosan a promising alternative to conventional functional monomers. Recently, chitosan molecularly-imprinted polymers have gained considerable attention and showed significant potential in many fields, such as curbing environmental pollution, medicine, protein separation and identification, and chiral-compound separation. These extensive applications are due to the polymers' desired selectivity, physical robustness, and thermal stability, as well as their low cost and easy preparation. Cross-linkers, which fix the functional groups of chitosan around imprinted molecules, play an important role in chitosan molecularly-imprinted polymers. This review summarizes the important cross-linkers of chitosan molecularly-imprinted polymers and illustrates the cross-linking mechanism of chitosan and cross-linkers based on the two glucosamine units. Finally, some significant attempts to further develop the application of chitosan in MIT are proposed.

No MeSH data available.


Related in: MedlinePlus

Cross-linking mechanism of chitosan and EGDE.
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ijms-16-18328-f007: Cross-linking mechanism of chitosan and EGDE.

Mentions: Similar to the mechanism involving ECH, the cross-linking mechanism of EGDE and chitosan, involves two types of ring-opening reactions. The open-loop epoxy group reacts with –NH2 or –OH of chitosan is mainly composed of two kinds of cross-linking reactions: (1) intra-molecular cross-linking reactions, in which the cross-linker reacts with two groups of one chain; and (2) inter-molecular cross-linking reactions, in which the cross-linker reacts with two groups of two chains. The hydrophilic group, –OH, will be introduced through the cross-linking reaction. However, the net structure renders the resultant polymer insoluble in water and dilute acid or dilute alkali. One cross-linking mechanism of chitosan and EGDE is presented in Figure 7.


Chitosan in Molecularly-Imprinted Polymers: Current and Future Prospects.

Xu L, Huang YA, Zhu QJ, Ye C - Int J Mol Sci (2015)

Cross-linking mechanism of chitosan and EGDE.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4581248&req=5

ijms-16-18328-f007: Cross-linking mechanism of chitosan and EGDE.
Mentions: Similar to the mechanism involving ECH, the cross-linking mechanism of EGDE and chitosan, involves two types of ring-opening reactions. The open-loop epoxy group reacts with –NH2 or –OH of chitosan is mainly composed of two kinds of cross-linking reactions: (1) intra-molecular cross-linking reactions, in which the cross-linker reacts with two groups of one chain; and (2) inter-molecular cross-linking reactions, in which the cross-linker reacts with two groups of two chains. The hydrophilic group, –OH, will be introduced through the cross-linking reaction. However, the net structure renders the resultant polymer insoluble in water and dilute acid or dilute alkali. One cross-linking mechanism of chitosan and EGDE is presented in Figure 7.

Bottom Line: These extensive applications are due to the polymers' desired selectivity, physical robustness, and thermal stability, as well as their low cost and easy preparation.Cross-linkers, which fix the functional groups of chitosan around imprinted molecules, play an important role in chitosan molecularly-imprinted polymers.Finally, some significant attempts to further develop the application of chitosan in MIT are proposed.

View Article: PubMed Central - PubMed

Affiliation: School of Liquor & Food Engineering, Guizhou University, Guiyang 550025, China. xulong19891026@163.com.

ABSTRACT
Chitosan is widely used in molecular imprinting technology (MIT) as a functional monomer or supporting matrix because of its low cost and high contents of amino and hydroxyl functional groups. The various excellent properties of chitosan, which include nontoxicity, biodegradability, biocompatibility, and attractive physical and mechanical performances, make chitosan a promising alternative to conventional functional monomers. Recently, chitosan molecularly-imprinted polymers have gained considerable attention and showed significant potential in many fields, such as curbing environmental pollution, medicine, protein separation and identification, and chiral-compound separation. These extensive applications are due to the polymers' desired selectivity, physical robustness, and thermal stability, as well as their low cost and easy preparation. Cross-linkers, which fix the functional groups of chitosan around imprinted molecules, play an important role in chitosan molecularly-imprinted polymers. This review summarizes the important cross-linkers of chitosan molecularly-imprinted polymers and illustrates the cross-linking mechanism of chitosan and cross-linkers based on the two glucosamine units. Finally, some significant attempts to further develop the application of chitosan in MIT are proposed.

No MeSH data available.


Related in: MedlinePlus