Limits...
Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial.

Haver VG, Hartman MH, Mateo Leach I, Lipsic E, Lexis CP, van Veldhuisen DJ, van Gilst WH, van der Horst IC, van der Harst P - Clin Res Cardiol (2015)

Bottom Line: Telomere length has been associated with coronary artery disease and heart failure.In age- and gender-adjusted models, LTL at baseline was significantly associated with age (beta ± standard error; -0.33 ± 0.01; P < 0.01), gender (0.15 ± 0.03; P < 0.01), TIMI flow pre-PCI (0.05 ± 0.03; P < 0.01), TIMI flow post-PCI (0.03 ± 0.04; P < 0.01), myocardial blush grade (-0.05 ± 0.07; P < 0.01), serum glucose levels (-0.11 ± 0.01; P = 0.03), and total leukocyte count (-0.11 ± 0.01; P = 0.04).Baseline LTL was associated with n-terminal pro-brain natriuretic peptide (NT-proBNP) at 4 months (-0.14 ± 0.01; P = 0.02), albeit not independent for age and gender.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.

ABSTRACT

Background: Telomere length has been associated with coronary artery disease and heart failure. We studied whether leukocyte telomere length is associated with left ventricular ejection fraction (LVEF) after ST-elevation myocardial infarction (STEMI).

Methods and results: Leukocyte telomere length (LTL) was determined using the monochrome multiplex quantitative PCR method in 353 patients participating in the glycometabolic intervention as adjunct to primary percutaneous coronary intervention in STEMI III trial. LVEF was assessed by magnetic resonance imaging. The mean age of patients was 58.9 ± 11.6 years, 75 % were male. In age- and gender-adjusted models, LTL at baseline was significantly associated with age (beta ± standard error; -0.33 ± 0.01; P < 0.01), gender (0.15 ± 0.03; P < 0.01), TIMI flow pre-PCI (0.05 ± 0.03; P < 0.01), TIMI flow post-PCI (0.03 ± 0.04; P < 0.01), myocardial blush grade (-0.05 ± 0.07; P < 0.01), serum glucose levels (-0.11 ± 0.01; P = 0.03), and total leukocyte count (-0.11 ± 0.01; P = 0.04). At 4 months after STEMI, LVEF was well preserved (54.1 ± 8.4 %) and was not associated with baseline LTL (P = 0.95). Baseline LTL was associated with n-terminal pro-brain natriuretic peptide (NT-proBNP) at 4 months (-0.14 ± 0.01; P = 0.02), albeit not independent for age and gender.

Conclusion: Our study does not support a role for LTL as a causal factor related to left ventricular ejection fraction after STEMI.

No MeSH data available.


Related in: MedlinePlus

Scatter plot showing association between LTL and age, with superimposed 95 % confidence interval and regression line. LTL leukocyte telomere length. Individual data points are shown as well as the superimposed regression line including the 95 % CI
© Copyright Policy - OpenAccess
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4580719&req=5

Fig1: Scatter plot showing association between LTL and age, with superimposed 95 % confidence interval and regression line. LTL leukocyte telomere length. Individual data points are shown as well as the superimposed regression line including the 95 % CI

Mentions: Leukocyte telomere length was negatively associated with age (Fig. 1). Univariate linear regression analyses revealed a significant association between baseline LTL with age, gender, active smoking behavior, single vessel disease, serum creatinine, and glucose levels (Table 2). Although univariately, active smokers seem to have longer LTL than non-smokers, this could be explained by the large age difference between smokers and non-smokers (54.4 ± 10.5 for smokers versus 64.3 ± 10.6 years for non-smokers). After including age and gender in the model, only serum glucose levels remained significantly associated with LTL. Univariately, ‘thrombolysis in myocardial infarction’ (TIMI) flow (both pre- and post-PCI), myocardial blush grade, and total leukocyte count were not associated with baseline LTL; however, after adjustment for age and gender, the association became significant. We tested for an effect of age underlying these association but could not identify a significant interaction effect (interaction coefficient myocardial blush grade = 3.2 × 10−4; 95 % confidence interval (CI) −5.5 × 10−3 to 6.1 × 10−3; P = 0.91; interaction coefficient TIMI flow pre-PCI ≤0.01; 95 % CI −0.01 to 0.01; P = 0.97; interaction coefficient TIMI flow post-PCI ≤0.01; 95 % CI −0.02 to 0.00; P = 0.15; interaction coefficient total leukocyte count = −0.14; 95 % CI −0.29 to 0.01; P = 0.08).Fig. 1


Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial.

Haver VG, Hartman MH, Mateo Leach I, Lipsic E, Lexis CP, van Veldhuisen DJ, van Gilst WH, van der Horst IC, van der Harst P - Clin Res Cardiol (2015)

Scatter plot showing association between LTL and age, with superimposed 95 % confidence interval and regression line. LTL leukocyte telomere length. Individual data points are shown as well as the superimposed regression line including the 95 % CI
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4580719&req=5

Fig1: Scatter plot showing association between LTL and age, with superimposed 95 % confidence interval and regression line. LTL leukocyte telomere length. Individual data points are shown as well as the superimposed regression line including the 95 % CI
Mentions: Leukocyte telomere length was negatively associated with age (Fig. 1). Univariate linear regression analyses revealed a significant association between baseline LTL with age, gender, active smoking behavior, single vessel disease, serum creatinine, and glucose levels (Table 2). Although univariately, active smokers seem to have longer LTL than non-smokers, this could be explained by the large age difference between smokers and non-smokers (54.4 ± 10.5 for smokers versus 64.3 ± 10.6 years for non-smokers). After including age and gender in the model, only serum glucose levels remained significantly associated with LTL. Univariately, ‘thrombolysis in myocardial infarction’ (TIMI) flow (both pre- and post-PCI), myocardial blush grade, and total leukocyte count were not associated with baseline LTL; however, after adjustment for age and gender, the association became significant. We tested for an effect of age underlying these association but could not identify a significant interaction effect (interaction coefficient myocardial blush grade = 3.2 × 10−4; 95 % confidence interval (CI) −5.5 × 10−3 to 6.1 × 10−3; P = 0.91; interaction coefficient TIMI flow pre-PCI ≤0.01; 95 % CI −0.01 to 0.01; P = 0.97; interaction coefficient TIMI flow post-PCI ≤0.01; 95 % CI −0.02 to 0.00; P = 0.15; interaction coefficient total leukocyte count = −0.14; 95 % CI −0.29 to 0.01; P = 0.08).Fig. 1

Bottom Line: Telomere length has been associated with coronary artery disease and heart failure.In age- and gender-adjusted models, LTL at baseline was significantly associated with age (beta ± standard error; -0.33 ± 0.01; P < 0.01), gender (0.15 ± 0.03; P < 0.01), TIMI flow pre-PCI (0.05 ± 0.03; P < 0.01), TIMI flow post-PCI (0.03 ± 0.04; P < 0.01), myocardial blush grade (-0.05 ± 0.07; P < 0.01), serum glucose levels (-0.11 ± 0.01; P = 0.03), and total leukocyte count (-0.11 ± 0.01; P = 0.04).Baseline LTL was associated with n-terminal pro-brain natriuretic peptide (NT-proBNP) at 4 months (-0.14 ± 0.01; P = 0.02), albeit not independent for age and gender.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.

ABSTRACT

Background: Telomere length has been associated with coronary artery disease and heart failure. We studied whether leukocyte telomere length is associated with left ventricular ejection fraction (LVEF) after ST-elevation myocardial infarction (STEMI).

Methods and results: Leukocyte telomere length (LTL) was determined using the monochrome multiplex quantitative PCR method in 353 patients participating in the glycometabolic intervention as adjunct to primary percutaneous coronary intervention in STEMI III trial. LVEF was assessed by magnetic resonance imaging. The mean age of patients was 58.9 ± 11.6 years, 75 % were male. In age- and gender-adjusted models, LTL at baseline was significantly associated with age (beta ± standard error; -0.33 ± 0.01; P < 0.01), gender (0.15 ± 0.03; P < 0.01), TIMI flow pre-PCI (0.05 ± 0.03; P < 0.01), TIMI flow post-PCI (0.03 ± 0.04; P < 0.01), myocardial blush grade (-0.05 ± 0.07; P < 0.01), serum glucose levels (-0.11 ± 0.01; P = 0.03), and total leukocyte count (-0.11 ± 0.01; P = 0.04). At 4 months after STEMI, LVEF was well preserved (54.1 ± 8.4 %) and was not associated with baseline LTL (P = 0.95). Baseline LTL was associated with n-terminal pro-brain natriuretic peptide (NT-proBNP) at 4 months (-0.14 ± 0.01; P = 0.02), albeit not independent for age and gender.

Conclusion: Our study does not support a role for LTL as a causal factor related to left ventricular ejection fraction after STEMI.

No MeSH data available.


Related in: MedlinePlus