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Apelin Levels In Isolated Coronary Artery Ectasia.

Bilik MZ, Kaplan İ, Yıldız A, Akıl MA, Acet H, Yüksel M, Polat N, Aydın M, Oylumlu M, Ertaș F, Kaya H, Alan S - Korean Circ J (2015)

Bottom Line: Glucose, creatinine, total cholesterol, triglyceride, low density lipoprotein cholesterol, and high density lipoprotein cholesterol levels were not significantly different between the two groups.In this study, we showed that patients with isolated CAE have decreased plasma apelin levels compared with the control group.Based on the data, a relationship between plasma apelin and isolated CAE was determined.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Medicine Faculty, Dicle University, Diyarbakır, Turkey.

ABSTRACT

Background and objectives: The etiopathogenesis of coronary artery ectasia (CAE) is not known completely. In most of the cases, CAE is associated with atherosclerosis; however, isolated CAE has a nonatherosclerotic mechanism. The association between atherosclerotic coronary artery disease and apelin has been examined in previous studies. However, the role of plasma apelin in isolated coronary artery ectasia has not been studied. In this study, we investigated the relationship between plasma apelin levels and isolated coronary artery ectasia.

Subjects and methods: The study population included a total of 54 patients. Twenty-six patients had isolated CAE (53.6±8.1 years); 28 patients with normal coronary arteries (51.6±8.8 years) and with similar risk factors and demographic characteristics served as the control group. Apelin levels were measured using an enzyme-linked immunoassay kit.

Results: Apelin level in the CAE group was significantly lower (apelin=0.181±0.159 ng/mL) than that in the control group (apelin=0.646±0.578 ng/mL) (p=0.033). Glucose, creatinine, total cholesterol, triglyceride, low density lipoprotein cholesterol, and high density lipoprotein cholesterol levels were not significantly different between the two groups.

Conclusion: In this study, we showed that patients with isolated CAE have decreased plasma apelin levels compared with the control group. Based on the data, a relationship between plasma apelin and isolated CAE was determined.

No MeSH data available.


Related in: MedlinePlus

Comparison of apelin levels between the CAE and control groups. In the CAE group, the mean apelin level is significantly lower (p=0.033). CAE: coronary artery ectasia.
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Figure 1: Comparison of apelin levels between the CAE and control groups. In the CAE group, the mean apelin level is significantly lower (p=0.033). CAE: coronary artery ectasia.

Mentions: The study included a total of 54 patients. The CAE group included 26 patients with isolated coronary artery ectasia (mean age 53.6±8.1 years), with 73.1% (n=19) of these patients being males. The control group included 28 patients with normal coronary arteries (mean age 51.6±8.8 years), with 64.3% (n=18) of these patients being males. There was no difference between the two groups in terms of basal demographic data (p>0.05). Demographic characteristics of the groups are presented in Table 1. We found that the apelin level in the CAE group was significantly lower (apelin=0.181±0.159 ng/mL) than that in the control group (apelin=0.646±0.578 ng/mL) (p=0.033) (Fig. 1). Glucose, creatinine, total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), and HDL-C levels were not significantly different between the two groups (p>0.05).


Apelin Levels In Isolated Coronary Artery Ectasia.

Bilik MZ, Kaplan İ, Yıldız A, Akıl MA, Acet H, Yüksel M, Polat N, Aydın M, Oylumlu M, Ertaș F, Kaya H, Alan S - Korean Circ J (2015)

Comparison of apelin levels between the CAE and control groups. In the CAE group, the mean apelin level is significantly lower (p=0.033). CAE: coronary artery ectasia.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4580697&req=5

Figure 1: Comparison of apelin levels between the CAE and control groups. In the CAE group, the mean apelin level is significantly lower (p=0.033). CAE: coronary artery ectasia.
Mentions: The study included a total of 54 patients. The CAE group included 26 patients with isolated coronary artery ectasia (mean age 53.6±8.1 years), with 73.1% (n=19) of these patients being males. The control group included 28 patients with normal coronary arteries (mean age 51.6±8.8 years), with 64.3% (n=18) of these patients being males. There was no difference between the two groups in terms of basal demographic data (p>0.05). Demographic characteristics of the groups are presented in Table 1. We found that the apelin level in the CAE group was significantly lower (apelin=0.181±0.159 ng/mL) than that in the control group (apelin=0.646±0.578 ng/mL) (p=0.033) (Fig. 1). Glucose, creatinine, total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), and HDL-C levels were not significantly different between the two groups (p>0.05).

Bottom Line: Glucose, creatinine, total cholesterol, triglyceride, low density lipoprotein cholesterol, and high density lipoprotein cholesterol levels were not significantly different between the two groups.In this study, we showed that patients with isolated CAE have decreased plasma apelin levels compared with the control group.Based on the data, a relationship between plasma apelin and isolated CAE was determined.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Medicine Faculty, Dicle University, Diyarbakır, Turkey.

ABSTRACT

Background and objectives: The etiopathogenesis of coronary artery ectasia (CAE) is not known completely. In most of the cases, CAE is associated with atherosclerosis; however, isolated CAE has a nonatherosclerotic mechanism. The association between atherosclerotic coronary artery disease and apelin has been examined in previous studies. However, the role of plasma apelin in isolated coronary artery ectasia has not been studied. In this study, we investigated the relationship between plasma apelin levels and isolated coronary artery ectasia.

Subjects and methods: The study population included a total of 54 patients. Twenty-six patients had isolated CAE (53.6±8.1 years); 28 patients with normal coronary arteries (51.6±8.8 years) and with similar risk factors and demographic characteristics served as the control group. Apelin levels were measured using an enzyme-linked immunoassay kit.

Results: Apelin level in the CAE group was significantly lower (apelin=0.181±0.159 ng/mL) than that in the control group (apelin=0.646±0.578 ng/mL) (p=0.033). Glucose, creatinine, total cholesterol, triglyceride, low density lipoprotein cholesterol, and high density lipoprotein cholesterol levels were not significantly different between the two groups.

Conclusion: In this study, we showed that patients with isolated CAE have decreased plasma apelin levels compared with the control group. Based on the data, a relationship between plasma apelin and isolated CAE was determined.

No MeSH data available.


Related in: MedlinePlus