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Major Factors Affecting Incidence of Childhood Thyroid Cancer in Belarus after the Chernobyl Accident: Do Nitrates in Drinking Water Play a Role?

Drozd VM, Saenko VA, Brenner AV, Drozdovitch V, Pashkevich VI, Kudelsky AV, Demidchik YE, Branovan I, Shiglik N, Rogounovitch TI, Yamashita S, Biko J, Reiners C - PLoS ONE (2015)

Bottom Line: This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident.However, there remains limited understanding of factors that modify the 131I-related risk.Analytic epidemiological studies designed to evaluate joint effect of nitrate content in groundwater and radiation present a promising avenue of research and may provide useful insights into etiology of thyroid cancer.

View Article: PubMed Central - PubMed

Affiliation: The International fund "Help for patients with radiation-induced thyroid cancer "Arnica", Minsk, Belarus; Department of Endocrinology, Belarusian Medical Academy for Postgraduate Education, Minsk, Belarus.

ABSTRACT
One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident. However, there remains limited understanding of factors that modify the 131I-related risk. Focusing on post-Chernobyl pediatric thyroid cancer in Belarus, we reviewed evidence of the effects of radiation, thyroid screening, and iodine deficiency on regional differences in incidence rates of thyroid cancer. We also reviewed current evidence on content of nitrate in groundwater and thyroid cancer risk drawing attention to high levels of nitrates in open well water in several contaminated regions of Belarus, i.e. Gomel and Brest, related to the usage of nitrogen fertilizers. In this hypothesis generating study, based on ecological data and biological plausibility, we suggest that nitrate pollution may modify the radiation-related risk of thyroid cancer contributing to regional differences in rates of pediatric thyroid cancer in Belarus. Analytic epidemiological studies designed to evaluate joint effect of nitrate content in groundwater and radiation present a promising avenue of research and may provide useful insights into etiology of thyroid cancer.

No MeSH data available.


Related in: MedlinePlus

Nitrate concentration (mg/L) in groundwater from open wells in different areas of Belarus in 1988–1990.Borders and oblast administrative centers are highlighted in violet.
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pone.0137226.g003: Nitrate concentration (mg/L) in groundwater from open wells in different areas of Belarus in 1988–1990.Borders and oblast administrative centers are highlighted in violet.

Mentions: The comparison of two maps, i.e. 131I deposition density (Fig 2) and nitrate concentration in groundwater well water (Fig 3), with estimates of incidence of pediatric thyroid cancer (Table 1) suggests that the differences in incidence rates among Gomel, Brest and Mogilev Oblasts may be related not only to exposure to 131I but also to the nitrate levels in groundwater.


Major Factors Affecting Incidence of Childhood Thyroid Cancer in Belarus after the Chernobyl Accident: Do Nitrates in Drinking Water Play a Role?

Drozd VM, Saenko VA, Brenner AV, Drozdovitch V, Pashkevich VI, Kudelsky AV, Demidchik YE, Branovan I, Shiglik N, Rogounovitch TI, Yamashita S, Biko J, Reiners C - PLoS ONE (2015)

Nitrate concentration (mg/L) in groundwater from open wells in different areas of Belarus in 1988–1990.Borders and oblast administrative centers are highlighted in violet.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4580601&req=5

pone.0137226.g003: Nitrate concentration (mg/L) in groundwater from open wells in different areas of Belarus in 1988–1990.Borders and oblast administrative centers are highlighted in violet.
Mentions: The comparison of two maps, i.e. 131I deposition density (Fig 2) and nitrate concentration in groundwater well water (Fig 3), with estimates of incidence of pediatric thyroid cancer (Table 1) suggests that the differences in incidence rates among Gomel, Brest and Mogilev Oblasts may be related not only to exposure to 131I but also to the nitrate levels in groundwater.

Bottom Line: This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident.However, there remains limited understanding of factors that modify the 131I-related risk.Analytic epidemiological studies designed to evaluate joint effect of nitrate content in groundwater and radiation present a promising avenue of research and may provide useful insights into etiology of thyroid cancer.

View Article: PubMed Central - PubMed

Affiliation: The International fund "Help for patients with radiation-induced thyroid cancer "Arnica", Minsk, Belarus; Department of Endocrinology, Belarusian Medical Academy for Postgraduate Education, Minsk, Belarus.

ABSTRACT
One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident. However, there remains limited understanding of factors that modify the 131I-related risk. Focusing on post-Chernobyl pediatric thyroid cancer in Belarus, we reviewed evidence of the effects of radiation, thyroid screening, and iodine deficiency on regional differences in incidence rates of thyroid cancer. We also reviewed current evidence on content of nitrate in groundwater and thyroid cancer risk drawing attention to high levels of nitrates in open well water in several contaminated regions of Belarus, i.e. Gomel and Brest, related to the usage of nitrogen fertilizers. In this hypothesis generating study, based on ecological data and biological plausibility, we suggest that nitrate pollution may modify the radiation-related risk of thyroid cancer contributing to regional differences in rates of pediatric thyroid cancer in Belarus. Analytic epidemiological studies designed to evaluate joint effect of nitrate content in groundwater and radiation present a promising avenue of research and may provide useful insights into etiology of thyroid cancer.

No MeSH data available.


Related in: MedlinePlus