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Prognostic Analysis of Patients with Ebola Virus Disease.

Zhang X, Rong Y, Sun L, Liu L, Su H, Zhang J, Teng G, Du N, Chen H, Fang Y, Zhan W, Kanu AB, Koroma SM, Jin B, Xu Z, Song H - PLoS Negl Trop Dis (2015)

Bottom Line: Also, using Pearson chi-square test, we identified that chest pain, coma, and viral load (>10(6) copies/ml) were significantly associated with poor survival of EVD patients.Interestingly, results revealed that patient's age, symptom of confusion, and viral load were the significantly associated with the survival of EVD cases (P = 0.017, P = 0.002, and P = 0.027, respectively).These results suggest that age, chest pain, coma, confusion and viral load are associated with the prognosis of EVD, in which viral load could be one of the most important factors for the survival of the disease.

View Article: PubMed Central - PubMed

Affiliation: PLA General Hospital, Beijing, China; Beijing 302 Hospital, Beijing, China.

ABSTRACT

Background: The Ebola virus causes an acute, serious illness which is often fatal if untreated. However, factors affecting the survival of the disease remain unclear. Here, we investigated the prognostic factors of Ebola virus disease (EVD) through various statistical models.

Methodology/principal findings: Sixty three laboratory-confirmed EVD patients with relatively complete clinical profiles were included in the study. All the patients were recruited at Jui Government Hospital, Sierra Leone between October 1st, 2014 and January 18th, 2015. We first investigated whether a single clinical presentation would be correlated with the survival of EVD. Log-rank test demonstrated that patients with viral load higher than 10(6) copies/ml presented significantly shorter survival time than those whose viral load were lower than 10(6) copies/ml (P = 0.005). Also, using Pearson chi-square test, we identified that chest pain, coma, and viral load (>10(6) copies/ml) were significantly associated with poor survival of EVD patients. Furthermore, we evaluated the effect of multiple variables on the survival of EVD by Cox proportional hazards model. Interestingly, results revealed that patient's age, symptom of confusion, and viral load were the significantly associated with the survival of EVD cases (P = 0.017, P = 0.002, and P = 0.027, respectively).

Conclusions/significance: These results suggest that age, chest pain, coma, confusion and viral load are associated with the prognosis of EVD, in which viral load could be one of the most important factors for the survival of the disease.

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Related in: MedlinePlus

Kaplan-Meier survival analysis for EBV patients.Cases were divided into 2 group based on the viral load in their peripheral blood.
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pntd.0004113.g001: Kaplan-Meier survival analysis for EBV patients.Cases were divided into 2 group based on the viral load in their peripheral blood.

Mentions: We first investigated patient’s age and the prognosis of EVD. Based on WHO and other literatures [9], patients were divided into two groups (≥40 years old and <40 years old). Log-rank test showed that the ≥40 years old group had moderately shorter survival time than the <40 years old group (P = 0.087). We further examined the viral load and the survival of EVD patients. Since 106 is the closest integer to the median value of the viral load of our study population, we divided the cases into two subsets according to the value. Data showed that patients with viral titer higher than 106 copies/ml presented significantly shorter survival time than those whose viral titer were lower than 106 copies/ml (P = 0.005, Fig 1).


Prognostic Analysis of Patients with Ebola Virus Disease.

Zhang X, Rong Y, Sun L, Liu L, Su H, Zhang J, Teng G, Du N, Chen H, Fang Y, Zhan W, Kanu AB, Koroma SM, Jin B, Xu Z, Song H - PLoS Negl Trop Dis (2015)

Kaplan-Meier survival analysis for EBV patients.Cases were divided into 2 group based on the viral load in their peripheral blood.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4580459&req=5

pntd.0004113.g001: Kaplan-Meier survival analysis for EBV patients.Cases were divided into 2 group based on the viral load in their peripheral blood.
Mentions: We first investigated patient’s age and the prognosis of EVD. Based on WHO and other literatures [9], patients were divided into two groups (≥40 years old and <40 years old). Log-rank test showed that the ≥40 years old group had moderately shorter survival time than the <40 years old group (P = 0.087). We further examined the viral load and the survival of EVD patients. Since 106 is the closest integer to the median value of the viral load of our study population, we divided the cases into two subsets according to the value. Data showed that patients with viral titer higher than 106 copies/ml presented significantly shorter survival time than those whose viral titer were lower than 106 copies/ml (P = 0.005, Fig 1).

Bottom Line: Also, using Pearson chi-square test, we identified that chest pain, coma, and viral load (>10(6) copies/ml) were significantly associated with poor survival of EVD patients.Interestingly, results revealed that patient's age, symptom of confusion, and viral load were the significantly associated with the survival of EVD cases (P = 0.017, P = 0.002, and P = 0.027, respectively).These results suggest that age, chest pain, coma, confusion and viral load are associated with the prognosis of EVD, in which viral load could be one of the most important factors for the survival of the disease.

View Article: PubMed Central - PubMed

Affiliation: PLA General Hospital, Beijing, China; Beijing 302 Hospital, Beijing, China.

ABSTRACT

Background: The Ebola virus causes an acute, serious illness which is often fatal if untreated. However, factors affecting the survival of the disease remain unclear. Here, we investigated the prognostic factors of Ebola virus disease (EVD) through various statistical models.

Methodology/principal findings: Sixty three laboratory-confirmed EVD patients with relatively complete clinical profiles were included in the study. All the patients were recruited at Jui Government Hospital, Sierra Leone between October 1st, 2014 and January 18th, 2015. We first investigated whether a single clinical presentation would be correlated with the survival of EVD. Log-rank test demonstrated that patients with viral load higher than 10(6) copies/ml presented significantly shorter survival time than those whose viral load were lower than 10(6) copies/ml (P = 0.005). Also, using Pearson chi-square test, we identified that chest pain, coma, and viral load (>10(6) copies/ml) were significantly associated with poor survival of EVD patients. Furthermore, we evaluated the effect of multiple variables on the survival of EVD by Cox proportional hazards model. Interestingly, results revealed that patient's age, symptom of confusion, and viral load were the significantly associated with the survival of EVD cases (P = 0.017, P = 0.002, and P = 0.027, respectively).

Conclusions/significance: These results suggest that age, chest pain, coma, confusion and viral load are associated with the prognosis of EVD, in which viral load could be one of the most important factors for the survival of the disease.

Show MeSH
Related in: MedlinePlus