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Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.

Fu Q, Tang X, Chen J, Su L, Zhang M, Wang L, Jing J, Zhou L - PLoS ONE (2015)

Bottom Line: Moreover, a weighted genotype score was found to be associated with TG levels (P = 3.28 × 10(-13)).However, no significant effects were found for the SNPs regarding susceptibility to CHD in the Chinese case-control populations.This study highlights the genotypes, genotype scores and haplotypes of the APOA4-APOA5-ZNF259-BUD13 gene cluster that were associated with TG levels in a Chinese population; however, the genetic variants in this gene cluster did not increase the risk of CHD in the Chinese population.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.

ABSTRACT

Background/aim: Recent genome-wide association studies have identified several loci influencing lipid levels. The present study focused on the triglycerides (TG)-associated locus, the APOA4-APOA5-ZNF259-BUD13 gene cluster on chromosome 11, to explore the role of genetic variants in this gene cluster in the development of increasing TG levels and coronary heart disease (CHD).

Methodology/principal findings: Six single nucleotide polymorphisms (SNPs), rs4417316, rs651821, rs6589566, rs7396835, rs964184 and rs17119975, in the APOA4-APOA5-ZNF259-BUD13 gene cluster were selected and genotyped in 5374 healthy Chinese subjects. There were strong significant associations between the six SNPs and TG levels (P < 1.0 × 10(-8)). Moreover, a weighted genotype score was found to be associated with TG levels (P = 3.28 × 10(-13)). The frequencies of three common haplotypes were observed to be significantly different between the high TG group and the low TG group (P < 0.05). However, no significant effects were found for the SNPs regarding susceptibility to CHD in the Chinese case-control populations.

Conclusions/significance: This study highlights the genotypes, genotype scores and haplotypes of the APOA4-APOA5-ZNF259-BUD13 gene cluster that were associated with TG levels in a Chinese population; however, the genetic variants in this gene cluster did not increase the risk of CHD in the Chinese population.

No MeSH data available.


Related in: MedlinePlus

Linkage disequilibrium patterns between genotyped SNPs around the APOA4-APOA5-ZNF259-BUD13 gene cluster in a Chinese Han population.The location of the genetic markers in the chromosome region (11q23.3) (55 kb) encompasses APOA4, APOA5, ZNF259 and BUD13. The direction of transcription of the genes is shown in arrows. The pair-wise LD between the SNPs is indicated by diamonds shaded in white-gray-red, which show the range of the LD matrix from D’ = 0 in white to D’ = 1 in red. The position of the six SNPs, rs17119975, rs964184, rs4417316, rs6589566, rs651821 and rs7396835, on the genes is indicated by the black rectangles.
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pone.0138652.g001: Linkage disequilibrium patterns between genotyped SNPs around the APOA4-APOA5-ZNF259-BUD13 gene cluster in a Chinese Han population.The location of the genetic markers in the chromosome region (11q23.3) (55 kb) encompasses APOA4, APOA5, ZNF259 and BUD13. The direction of transcription of the genes is shown in arrows. The pair-wise LD between the SNPs is indicated by diamonds shaded in white-gray-red, which show the range of the LD matrix from D’ = 0 in white to D’ = 1 in red. The position of the six SNPs, rs17119975, rs964184, rs4417316, rs6589566, rs651821 and rs7396835, on the genes is indicated by the black rectangles.

Mentions: The general characteristics and TG levels of the participants are presented in Table 1. In the 5347 subjects, BMI was significantly associated with TG levels (P<0.001). The TG levels were significantly higher in subjects whose BMI ≥25 kg/m2. However, no associations were observed between age, sex, drinking, smoking and TG levels. The linkage disequilibrium (LD) pattern between the six SNPs in the APOA4-APOA5-ZNF259-BUD13 gene cluster in the Chinese Han population is shown in Fig 1 and S1 Table.


Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.

Fu Q, Tang X, Chen J, Su L, Zhang M, Wang L, Jing J, Zhou L - PLoS ONE (2015)

Linkage disequilibrium patterns between genotyped SNPs around the APOA4-APOA5-ZNF259-BUD13 gene cluster in a Chinese Han population.The location of the genetic markers in the chromosome region (11q23.3) (55 kb) encompasses APOA4, APOA5, ZNF259 and BUD13. The direction of transcription of the genes is shown in arrows. The pair-wise LD between the SNPs is indicated by diamonds shaded in white-gray-red, which show the range of the LD matrix from D’ = 0 in white to D’ = 1 in red. The position of the six SNPs, rs17119975, rs964184, rs4417316, rs6589566, rs651821 and rs7396835, on the genes is indicated by the black rectangles.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4580433&req=5

pone.0138652.g001: Linkage disequilibrium patterns between genotyped SNPs around the APOA4-APOA5-ZNF259-BUD13 gene cluster in a Chinese Han population.The location of the genetic markers in the chromosome region (11q23.3) (55 kb) encompasses APOA4, APOA5, ZNF259 and BUD13. The direction of transcription of the genes is shown in arrows. The pair-wise LD between the SNPs is indicated by diamonds shaded in white-gray-red, which show the range of the LD matrix from D’ = 0 in white to D’ = 1 in red. The position of the six SNPs, rs17119975, rs964184, rs4417316, rs6589566, rs651821 and rs7396835, on the genes is indicated by the black rectangles.
Mentions: The general characteristics and TG levels of the participants are presented in Table 1. In the 5347 subjects, BMI was significantly associated with TG levels (P<0.001). The TG levels were significantly higher in subjects whose BMI ≥25 kg/m2. However, no associations were observed between age, sex, drinking, smoking and TG levels. The linkage disequilibrium (LD) pattern between the six SNPs in the APOA4-APOA5-ZNF259-BUD13 gene cluster in the Chinese Han population is shown in Fig 1 and S1 Table.

Bottom Line: Moreover, a weighted genotype score was found to be associated with TG levels (P = 3.28 × 10(-13)).However, no significant effects were found for the SNPs regarding susceptibility to CHD in the Chinese case-control populations.This study highlights the genotypes, genotype scores and haplotypes of the APOA4-APOA5-ZNF259-BUD13 gene cluster that were associated with TG levels in a Chinese population; however, the genetic variants in this gene cluster did not increase the risk of CHD in the Chinese population.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.

ABSTRACT

Background/aim: Recent genome-wide association studies have identified several loci influencing lipid levels. The present study focused on the triglycerides (TG)-associated locus, the APOA4-APOA5-ZNF259-BUD13 gene cluster on chromosome 11, to explore the role of genetic variants in this gene cluster in the development of increasing TG levels and coronary heart disease (CHD).

Methodology/principal findings: Six single nucleotide polymorphisms (SNPs), rs4417316, rs651821, rs6589566, rs7396835, rs964184 and rs17119975, in the APOA4-APOA5-ZNF259-BUD13 gene cluster were selected and genotyped in 5374 healthy Chinese subjects. There were strong significant associations between the six SNPs and TG levels (P < 1.0 × 10(-8)). Moreover, a weighted genotype score was found to be associated with TG levels (P = 3.28 × 10(-13)). The frequencies of three common haplotypes were observed to be significantly different between the high TG group and the low TG group (P < 0.05). However, no significant effects were found for the SNPs regarding susceptibility to CHD in the Chinese case-control populations.

Conclusions/significance: This study highlights the genotypes, genotype scores and haplotypes of the APOA4-APOA5-ZNF259-BUD13 gene cluster that were associated with TG levels in a Chinese population; however, the genetic variants in this gene cluster did not increase the risk of CHD in the Chinese population.

No MeSH data available.


Related in: MedlinePlus